Functions of nonclassical MHC and non-MHC-encoded class I molecules

A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis

1996 • 3,682 citations

CD1d-Restricted and TCR-Mediated Activation of V _α 14 NKT Cells by Glycosylceramides

1997 • 2,370 citations

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

1998 • 2,114 citations

Requirement for V _α 14 NKT Cells in IL-12-Mediated Rejection of Tumors

1997 • 1,226 citations

Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells

1998 • 1,134 citations

Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium.

1996 • 1,010 citations

HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A

1998 • 998 citations

Recognition of a lipid antigen by CD1-restricted αβ+ T cells

1994 • 976 citations

A Common Inhibitory Receptor for Major Histocompatibility Complex Class I Molecules on Human Lymphoid and Myelomonocytic Cells

1997 • 933 citations

CD1 Recognition by Mouse NK1 ⁺ T Lymphocytes

1995 • 903 citations

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

1998 • 852 citations

CD1-Restricted T Cell Recognition of Microbial Lipoglycan Antigens

1995 • 751 citations

Recognition of Human Histocompatibility Leukocyte Antigen (HLA)-E Complexed with HLA Class I Signal Sequence–derived Peptides by CD94/NKG2 Confers Protection from Natural Killer Cell–mediated Lysis

1998 • 706 citations

Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes

1998 • 642 citations

Crystal Structure of the Hemochromatosis Protein HFE and Characterization of Its Interaction with Transferrin Receptor

1998 • 635 citations

Crystal Structure of Mouse CD1: An MHC-Like Fold with a Large Hydrophobic Binding Groove

1997 • 629 citations

CD1d1 Mutant Mice Are Deficient in Natural T Cells That PromptlyProduce IL-4

1997 • 612 citations

HFE gene knockout produces mouse model of hereditary hemochromatosis

1998 • 535 citations

Requirements for CD1d Recognition by Human Invariant Vα24+ CD4−CD8− T Cells

1997 • 527 citations

Differential Effects of Cytolytic T Cell Subsets on Intracellular Infection

1997 • 526 citations

Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules.

1998 • 498 citations

HLA-E Surface Expression Depends on Binding of TAP-Dependent Peptides Derived from Certain HLA Class I Signal Sequences

1998 • 495 citations

Impaired NK1+ T Cell Development and Early IL-4 Production in CD1-Deficient Mice

1997 • 494 citations

The human major histocompatibility complex class Ib molecule HLA‐E binds signal sequence‐derived peptides with primary anchor residues at positions 2 and 9

1997 • 489 citations

Protection from Natural Killer Cell-Mediated Lysis by HLA-G Expression on Target Cells

1996 • 489 citations

The Hemochromatosis Founder Mutation in HLA-H Disrupts β2-Microglobulin Interaction and Cell Surface Expression

1997 • 481 citations

Structural Requirements for Glycolipid Antigen Recognition by CD1b-Restricted T Cells

1997 • 437 citations

Cutting Edge: Human Myelomonocytic Cells Express an Inhibitory Receptor for Classical and Nonclassical MHC Class I Molecules

1998 • 430 citations

Natural Ligand of Mouse CD1d1: Cellular Glycosylphosphatidylinositol

1998 • 399 citations

Hereditary hemochromatosis: Effects of C282Y and H63D mutations on association with β ₂ -microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells

1997 • 388 citations

Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes.

1998 • 383 citations

Triplet repeat polymorphism in the transmembrane region of the MICA gene: A strong association of six GCT repetitions with Behçet disease

1997 • 366 citations

HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer

1998 • 366 citations

Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis

1997 • 342 citations

The Mannose Receptor Delivers Lipoglycan Antigens to Endosomes for Presentation to T Cells by CD1b Molecules

1997 • 339 citations

The membrane-bound and soluble forms of HLA-G bind identical sets of endogenous peptides but differ with respect to TAP association

1995 • 320 citations

Selective Ability of Mouse CD1 to Present Glycolipids: α-Galactosylceramide Specifically Stimulates Vα14+ NK T Lymphocytes

1998 • 319 citations

Identification of a Thymic Epithelial Cell Subset Sharing Expression of the Class Ib HLA-G Molecule with Fetal Trophoblasts

1997 • 296 citations

Identification of a tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen

1994 • 275 citations

TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide

1998 • 275 citations

Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract

1997 • 259 citations

Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases

1998 • 236 citations

Co-trafficking of HFE, a Nonclassical Major Histocompatibility Complex Class I Protein, with the Transferrin Receptor Implies a Role in Intracellular Iron Regulation

1998 • 234 citations

CD1c restricts responses of mycobacteria-specific T cells. Evidence for antigen presentation by a second member of the human CD1 family.

1996 • 212 citations

Structural Features Impose Tight Peptide Binding Specificity in the Nonclassical MHC Molecule HLA-E

1998 • 206 citations

Nonclassical HLA-G molecules are classical peptide presenters

1996 • 201 citations

Expression of killer cell inhibitory receptors on human uterine natural killer cells

1997 • 187 citations

HLA-G1 protein expression is not essential for fetal survival

1998 • 181 citations

Molecular Interaction of CD1b with Lipoglycan Antigens

1998 • 180 citations

Murine CD8+ T cells that specifically delete autologous CD4+ T cells expressing Vβ8 TCR: a role of the Qa-1 molecule

1995 • 175 citations

The CD94/NKG2-A inhibitory receptor complex is involved in natural killer cell-mediated recognition of cells expressing HLA-G1.

1997 • 159 citations

TCR V alpha 24 and V beta 11 coexpression defines a human NK1 T cell analog containing a unique Th0 subpopulation.

1997 • 159 citations

Nonclassical binding of formylated peptide in crystal structure of the MHC class lb molecule H2-M3

1995 • 155 citations

p49, a putative HLA class I-specific inhibitory NK receptor belonging to the immunoglobulin superfamily

1998 • 155 citations

Identification of an H2-M3-Restricted Listeria Epitope: Implications for Antigen Presentation by M3

1996 • 148 citations

The Tyrosine-Containing Cytoplasmic Tail of CD1b Is Essential for Its Efficient Presentation of Bacterial Lipid Antigens

1998 • 144 citations

Trophoblast Class I Major Histocompatibility Complex (MHC) Products Are Resistant to Rapid Degradation Imposed by the Human Cytomegalovirus (HCMV) Gene Products US2 and US11

1998 • 142 citations

T cell vaccination induces T cell receptor Vβ-specific Qa-1-restricted regulatory CD8⁺T cells

1998 • 140 citations

CD94/NKG2 is the predominant inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells.

1997 • 140 citations

Human Histocompatibility Leukocyte Antigen (HLA)-G Molecules Inhibit NKAT3 Expressing Natural Killer Cells

1997 • 139 citations

Close phenotypic and functional similarities between human and murine alphabeta T cells expressing invariant TCR alpha-chains.

1997 • 135 citations

MurineNkg2dandCd94are clustered within the natural killer complex and are expressed independently in natural killer cells

1998 • 128 citations

Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class 1 molecule on cytotrophoblasts.

1991 • 128 citations

Cloning of a mouse homolog of CD94 extends the family of C‐type lectins on murine natural killer cells

1997 • 122 citations

A Listeria monocytogenes Pentapeptide Is Presented to Cytolytic T Lymphocytes by the H2-M3 MHC Class Ib Molecule

1996 • 111 citations

Dominance of a single peptide bound to the class I(B) molecule, Qa-1b.

1997 • 103 citations

Interaction of HLA-E with Peptides and the Peptide Transporter In Vitro: Implications for its Function in Antigen Presentation

1998 • 101 citations

Suppression of Immune Responses by CD8 Cells. II. Qa-1 on Activated B Cells Stimulates CD8 Cell Suppression of T Helper 2 Responses

1998 • 98 citations

Kupffer cell staining by an HFE‐specific monoclonal antibody: implications for hereditary haemochromatosis

1998 • 91 citations

HLA‐G recognition by human natural killer cells. Involvement of CD94 both as inhibitory and as activating receptor complex

1997 • 90 citations

Qa-1b Binds Conserved Class I Leader Peptides Derived from Several Mammalian Species

1998 • 87 citations

Major Histocompatibility Complex Class I Molecules Modulate Activation Threshold and Early Signaling of T Cell Antigen Receptor–γ/δ Stimulated by Nonpeptidic Ligands

1997 • 87 citations

Multiple receptors for HLA-G on human natural killer cells

1997 • 82 citations

H2-M3 Restricted Presentation of a Listeria-derived Leader Peptide

1998 • 71 citations

Herpes simplex virus blocks intracellular transport of HLA-G in placentally derived human cells.

1996 • 71 citations

Qa‐1 interaction and T cell recognition of the Qa‐1 determinant modifier peptide

1997 • 63 citations

The effect of the proteasome inhibitor lactacystin on the presentation of transporter associated with antigen processing (TAP)-dependent and TAP-independent peptide epitopes by class I molecules.

1997 • 55 citations

Transporters Associated with Antigen Processing (TAP)-independent Presentation of Soluble Insulin to α/β T Cells by the Class Ib Gene Product, Qa-1b

1998 • 51 citations

Two genes in the rat homologous to human NKG2

1998 • 49 citations

HLA-G functions as a restriction element and a transplantation antigen in mice

1997 • 47 citations

H2-M3^wt-restricted, Listeria monocytogenes-specific CD8 T cells recognize a novel, hydrophobic, protease-resistant, periodate-sensitive antigen

1996 • 37 citations

Constitutive and regulated expression of the class Ib molecule Qa‐1 in pancreatic β cells

1998 • 36 citations

Peptide binding to the class Ib molecule, Qa-1b.

1997 • 36 citations

The Pathway for Processing Leader-Derived Peptides that Regulate the Maturation and Expression of Qa-1b

1998 • 33 citations

H2M3wt-restricted, Listeria monocytogenes-immune CD8 T cells respond to multiple formylated peptides and to a variety of gram-positive and gram- negative bacteria

1998 • 28 citations

Listeria monocytogenes-Infected Hepatocytes Are Targets of Major Histocompatibility Complex Class Ib-Restricted Antilisterial Cytotoxic T Lymphocytes

1998 • 25 citations

Cytotoxic T Lymphocyte Recognition of HLA-G in Mice

1997 • 22 citations