Immune Selection for Altered Antigen Processing Leads to Cytotoxic T Lymphocyte Escape in Chronic HIV-1 Infection

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1994 • 2,480 citations

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1999 • 2,206 citations

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1997 • 1,206 citations

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2004 • 849 citations

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2002 • 754 citations

Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia

2000 • 693 citations

Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes

2002 • 670 citations

ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum

2002 • 620 citations

Evolution and transmission of stable CTL escape mutations in HIV infection

2001 • 549 citations

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2002 • 518 citations

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2002 • 486 citations

Clustered Mutations in HIV-1 Gag Are Consistently Required for Escape from Hla-B27–Restricted Cytotoxic T Lymphocyte Responses

2001 • 459 citations

Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants

1994 • 418 citations

Replicative Fitness of Protease Inhibitor-Resistant Mutants of Human Immunodeficiency Virus Type 1

1999 • 400 citations

Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef

1999 • 387 citations

TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective

1993 • 365 citations

Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection

2002 • 363 citations

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2000 • 355 citations

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2002 • 345 citations

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2001 • 322 citations

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2002 • 310 citations

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1994 • 261 citations

Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection

2004 • 251 citations

Novel, Cross-Restricted, Conserved, and Immunodominant Cytotoxic T Lymphocyte Epitopes in Slow Progressors in HIV Type 1 Infection

1996 • 241 citations

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The Differential Ability of HLA B^*5701⁺Long-Term Nonprogressors and Progressors To Restrict Human Immunodeficiency Virus Replication Is Not Caused by Loss of Recognition of Autologous ViralgagSequences

2003 • 159 citations

The Cytosolic Endopeptidase, Thimet Oligopeptidase, Destroys Antigenic Peptides and Limits the Extent of MHC Class I Antigen Presentation

2003 • 156 citations

Major differences in transporter associated with antigen presentation (TAP)-dependent translocation of MHC class I-presentable peptides and the effect of flanking sequences.

1995 • 155 citations

Translocation of long peptides by transporters associated with antigen processing (TAP)

1996 • 149 citations

Major Histocompatibility Complex Class I-presented Antigenic Peptides Are Degraded in Cytosolic Extracts Primarily by Thimet Oligopeptidase

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Enhanced Detection of Human Immunodeficiency Virus Type 1-Specific T-Cell Responses to Highly Variable Regions by Using Peptides Based on Autologous Virus Sequences

2003 • 145 citations

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1997 • 142 citations

Consistent Patterns in the Development and Immunodominance of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8⁺T-Cell Responses following Acute HIV-1 Infection

2002 • 131 citations

Dynamics of CD4 and CD8 T Cell Responses to Cytomegalovirus in Healthy Human Donors

2002 • 122 citations

Construction andIn VitroProperties of HIV-1 Mutants with Deletions in "Nonessential" Genes

1994 • 117 citations

Amprenavir-resistant HIV-1 exhibits lopinavir cross-resistance and reduced replication capacity

2002 • 106 citations

Identification of Dominant Optimal HLA-B60- and HLA-B61-Restricted Cytotoxic T-Lymphocyte (CTL) Epitopes: Rapid Characterization of CTL Responses by Enzyme-Linked Immunospot Assay

2000 • 103 citations

Analysis of the fine specificity of rat, mouse and human TAP peptide transporters

1995 • 102 citations

Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site

2000 • 95 citations

Point mutation flanking a CTL epitope ablates in vitro and in vivo recognition of a full-length viral protein.

1997 • 93 citations

Polymorphism in the alpha 1 helix of the HLA-B heavy chain can have an overriding influence on peptide-binding specificity.

1997 • 91 citations

Human Transporters Associated with Antigen Processing (Taps) Select Epitope Precursor Peptides for Processing in the Endoplasmic Reticulum and Presentation to T Cells

1999 • 89 citations

Fitness of Human Immunodeficiency Virus Type 1 Protease Inhibitor-Selected Single Mutants

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2002 • 78 citations

Presentation of endogenous peptide/MHC class I complexes is profoundly influenced by specific C-terminal flanking residues.

1995 • 57 citations

Sequences That Flank Subdominant and Cryptic Epitopes Influence the Proteolytic Generation of MHC Class I-Presented Peptides

2000 • 56 citations

HLA-B57-Restricted Cytotoxic T-Lymphocyte Activity in a Single Infected Subject toward Two Optimal Epitopes, One of Which Is Entirely Contained within the Other

2000 • 51 citations

Efficient Processing of the Immunodominant, HLA-A*0201-Restricted Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitope despite Multiple Variations in the Epitope Flanking Sequences

1999 • 46 citations

Differential effects of flanking residues on presentation of epitopes from chimeric peptides

1994 • 40 citations

Effect of epitope flanking residues on the presentation of N-terminal cytotoxic T lymphocyte epitopes

1999 • 28 citations

Immunology taught by Darwin

2002 • 27 citations

Lessons from viral manipulation of protein disposal pathways

2002 • 26 citations

Specific Proteolytic Cleavages Limit the Diversity of the Pool of Peptides Available to MHC Class I Molecules in Living Cells

1999 • 25 citations

Lessons from viral manipulation of protein disposal pathways

2002 • 23 citations