Mechanisms of Tumor Evasion

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Cancer immunoediting: from immunosurveillance to tumor escape

2002 • 4,911 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

The Concept of Immunological Surveillance

2015 • 1,586 citations

Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation

2002 • 1,529 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer

2001 • 1,309 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

Immunity to Methylcholanthrene-Induced Sarcomas

1957 • 1,241 citations

Escape of Human Solid Tumors from T–Cell Recognition: Molecular Mechanisms and Functional Significance

1999 • 1,168 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

2002 • 1,035 citations

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

2001 • 1,033 citations

Natural selection of tumor variants in the generation of “tumor escape” phenotypes

2002 • 1,014 citations

Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB

1999 • 1,006 citations

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo

1998 • 933 citations

Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients.

2001 • 860 citations

The roles of IFNγ in protection against tumor development and cancer immunoediting

2002 • 852 citations

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo

1998 • 828 citations

Down-Regulation of the Antitumor Immune Response

1985 • 676 citations

Alterations in Signal Transduction Molecules in T Lymphocytes from Tumor-Bearing Mice

1992 • 650 citations

Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells

2001 • 644 citations

Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFNγ receptors

1994 • 619 citations

G<scp>ENETICS OF</scp> M<scp>YELOID</scp> L<scp>EUKEMIAS</scp>

2002 • 530 citations

Loss of Functional Beta2-Microglobulin in Metastatic Melanomas From Five Patients Receiving Immunotherapy

1996 • 515 citations

Regulation of T Cell Receptor CD3ζ Chain Expression byl-Arginine

2002 • 460 citations

Antigen-processing machinery breakdown and tumor growth

2000 • 444 citations

Blocking of cell‐mediated tumor immunity by sera from patients with growing neoplasms

1971 • 423 citations

Human lung carcinomas express Fas ligand.

1997 • 395 citations

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness.

1987 • 391 citations

Loss of T-cell receptor zeta chain and p56lck in T-cells infiltrating human renal cell carcinoma.

1993 • 385 citations

Blocked Ras Activation in Anergic CD4 ⁺ T Cells

1996 • 380 citations

Impaired in Vitro Lymphocyte Transformation in Hodgkin's Disease

1965 • 379 citations

Diversity of Cytokine Synthesis and Function of Mouse CD4⁺ T Cells

1991 • 371 citations

HLA class I antigen downregulation in human cancers: T-cell immunotherapy revives an old story

1999 • 366 citations

Hydrogen peroxide secreted by tumor‐derived macrophages down‐modulates signal‐transducing zeta molecules and inhibits tumor‐specific T cell‐and natural killer cell‐mediated cytotoxicity

1996 • 364 citations

Regulation of Nitric Oxide Production by Arginine Metabolic Enzymes

2000 • 344 citations

Cells Expressing Indoleamine 2,3-Dioxygenase Inhibit T Cell Responses

2002 • 344 citations

Decreased expression of the signal-transducing zeta chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma.

1993 • 344 citations

Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 ζ chain of T-cell receptor complex and antigen-specific T-cell responses

1996 • 341 citations

Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease

2002 • 332 citations

Functional properties of tumor-infiltrating and blood lymphocytes in patients with solid tumors: effects of tumor cells and their supernatants on proliferative responses of lymphocytes.

1986 • 319 citations

MHC antigens and tumor escape from immune surveillance

2001 • 300 citations

Antigen presentation by MHC class I and its regulation by interferon γ

1999 • 287 citations

Dendritic Cells in Antitumor Immune Responses

1996 • 282 citations

Molecular Cloning of the Zeta Chain of the T Cell Antigen Receptor

1988 • 275 citations

The β2-microglobulin gene is on chromosome 15 and not in the HL-A region

1975 • 274 citations

Multiple Genetic Alterations Cause Frequent and Heterogeneous Human Histocompatibility Leukocyte Antigen Class I Loss in Cervical Cancer

2000 • 270 citations

HLA class I antigen abnormalities and immune escape by malignant cells

2002 • 264 citations

Generation and decay of the immune response to a progressive fibrosarcoma. I. Ly-1+2- suppressor T cells down-regulate the generation of Ly-1-2+ effector T cells.

1984 • 249 citations

The Fas counterattack: cancer as a site of immune privilege

1999 • 240 citations

Lymphocyte apoptosis induced by Fas ligand- expressing ovarian carcinoma cells. Implications for altered expression of T cell receptor in tumor-associated lymphocytes.

1998 • 238 citations

Rexpression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells following 5-aza-2?-deoxycytidine treatment

2001 • 234 citations

The nature of molecular recognition by T cells

2003 • 228 citations

Differences in the antigens recognized by cytolytic T cells on two successive metastases of a melanoma patient are consistent with immune selection

1995 • 225 citations

Follicular lymphomas can be induced to present alloantigen efficiently: a conceptual model to improve their tumor immunogenicity.

1995 • 224 citations

MIC Genes: From Genetics to Biology

2001 • 221 citations

How melanoma cells evade trail-induced apoptosis

2001 • 211 citations

Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition?

2002 • 206 citations

A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer

1996 • 196 citations

Alterations in T cell receptor and signal transduction molecules in melanoma patients.

1995 • 192 citations

DNA hypermethylation is a mechanism for loss of expression of the HLA class I genes in human esophageal squamous cell carcinomas

2001 • 191 citations

Immune escape of melanoma: first evidence of structural alterations in two distinct components of the MHC class I antigen processing pathway.

2001 • 189 citations

Molecular dynamics of MHC genesis unraveled by sequence analysis of the 1,796,938-bp HLA class I region

1999 • 179 citations

Structure and function of the human MHC class Ib molecules HLA‐E, HLA‐F and HLA‐G

1998 • 173 citations

Regulation of macrophage functions by L-arginine.

1989 • 173 citations

Decreased expression of signal-transducing zeta chain in peripheral T cells and natural killer cells in patients with cervical cancer.

1996 • 169 citations

Deficiency of Transporter for Antigen Presentation (TAP) in Tumor Cells Allows Evasion of Immune Surveillance and Increases Tumorigenesis

1999 • 167 citations

Expression of HLA-A,B,C antigens on primary and metastatic tumor cell populations of human carcinomas.

1991 • 160 citations

Signal transduction events leading to T-cell lymphokine gene expression

1993 • 151 citations

Assignment of the major histocompatibility complex to a region of the short arm of human chromosome 6.

1977 • 151 citations

Absent or low expression of the zeta chain in T cells at the tumor site correlates with poor survival in patients with oral carcinoma.

1998 • 147 citations

Mechanisms of apoptosis in T cells from patients with renal cell carcinoma.

1999 • 145 citations

5-aza-2'-deoxycytidine-induced expression of functional cancer testis antigens in human renal cell carcinoma: immunotherapeutic implications.

2002 • 142 citations

Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways.

1994 • 133 citations

Persistent Immunologic Abnormalities in Long-Term Survivors of Advanced Hodgkin's Disease

1980 • 131 citations

Multiple mechanisms underlie HLA dysregulation in cervical cancer

2000 • 129 citations

Role of Suppressor Cells in Depression of In Vitro Lymphoproliferative Responses of Lung Cancer and Breast Cancer Patients&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;

1978 • 129 citations

HLA class I gene expression on human primary tumours and autologous metastases: demonstration of selective losses of HLA antigens on colorectal, gastric and laryngeal carcinomas

1989 • 127 citations

Prolonged Upregulation of the Expression of HLA Class I Antigens and Co stimulatory Molecules on Melanoma Cells Treated with 5-aza-2??-deoxycytidine (5-AZA-CdR)

1999 • 126 citations

Renal cell carcinoma–derived gangliosides suppress nuclear factor-κB activation in T cells

1999 • 124 citations

HLA expression in uveal melanoma: there is no rule without some exception

2002 • 119 citations

Caspase-mediated degradation of T-cell receptor zeta-chain.

1999 • 118 citations

Gradual Loss of T-Helper 1 Populations in Spleen of Mice During Progressive Tumor Growth

1995 • 117 citations

Chromosome loss is the most frequent mechanism contributing to HLA haplotype loss in human tumors

1999 • 116 citations

Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells.

1996 • 115 citations

The role of Fas/FasL in immunosuppression induced by human tumors

1998 • 115 citations

Immunologic, virologic, and pathologic studies of regression of autochthonous Moloney sarcoma virus-induced tumors in mice.

1968 • 114 citations

L-Arginine regulates the expression of the T-cell receptor zeta chain (CD3zeta) in Jurkat cells.

2001 • 113 citations

Spontaneous ex vivo apoptosis of peripheral blood mononuclear cells in patients with head and neck cancer.

1999 • 112 citations

Deficient expression of components of the MHC class I antigen processing machinery in human cervical carcinoma

2001 • 112 citations

In Vivo Expression of B7-1 and B7-2 By Follicular Lymphoma Cells Can Prevent Induction of T-Cell Anergy But Is Insufficient to Induce Significant T-Cell Proliferation

1997 • 106 citations

Multiple mechanisms generate HLA class I altered phenotypes in laryngeal carcinomas: high frequency of HLA haplotype loss associated with loss of heterozygosity in chromosome region 6p21

2002 • 106 citations

Selective Histocompatibility Leukocyte Antigen (Hla)-A2 Loss Caused by Aberrant Pre-mRNA Splicing in 624mel28 Melanoma Cells

1999 • 104 citations

TAP expression provides a general method for improving the recognition of malignant cells in vivo

2000 • 102 citations

Interleukin-10: a cytokine used by tumors to escape immunosurveillance

1999 • 102 citations

Cloning and Characterization of the Genes Encoding the Murine Homoloties of the Human Melanoma Antigens MARTI and gp100

1997 • 100 citations

Zeta chain and CD28 are poorly expressed on T lymphocytes from chronic lymphocytic leukemia.

1996 • 99 citations

Expression of cytokine genes or proteins and signaling molecules in lymphocytes associated with human ovarian carcinoma

1996 • 99 citations

HLA-G and MIC expression in tumors and their role in anti-tumor immunity

2003 • 99 citations

Complete loss of HLA class I antigen expression on melanoma cells: A result of successive mutational events

2002 • 97 citations

Preferential clonogenic deficit of CD8-positive T-lymphocytes infiltrating human solid tumors.

1988 • 95 citations

T cells from patients with Hodgkin's disease have a defective T-cell receptor zeta chain expression that is reversible by T-cell stimulation with CD3 and CD28

1996 • 93 citations

Immunoregulation in cancer-bearing hosts. Down-regulation of gene expression and cytotoxic function in CD8+ T cells.

1992 • 92 citations

Human leukocyte antigen class I allelic and haplotype loss in squamous cell carcinoma of the head and neck: clinical and immunogenetic consequences.

2000 • 91 citations

Dendritic Cells Infected with PoxvIn Vitro iruses Encoding MART-1/ Melan A Sensitize T Lymphocytes In Vitro

1997 • 91 citations

Anergic Th1 cells express altered levels of the protein tyrosine kinases p56lck and p59fyn.

1992 • 89 citations

Loss of an HLA haplotype in pancreas cancer tissue and its corresponding tumor derived cell line

1996 • 85 citations

Tumor-induced suppression of T lymphocyte proliferation coincides with inhibition of Jak3 expression and IL-2 receptor signaling: role of soluble products from human renal cell carcinomas.

1997 • 84 citations

Immunoselection by T lymphocytes generates repeated MHC class I-deficient metastatic tumor variants

2000 • 84 citations

T cells from renal cell carcinoma patients exhibit an abnormal pattern of kappa B-specific DNA-binding activity: a preliminary report.

1994 • 84 citations

Expression of HLA class I antigens on hepatocytes in liver disease.

1986 • 84 citations

Suppressor Cells in Tumor-Bearing Mice Capable of Nonspecific Blocking of in Vitro Immunization Against Transplant Antigens

1975 • 83 citations

Alterations in NF B Activation in T Lymphocytes of Patients With Renal Cell Carcinoma

1999 • 83 citations

Association of tapasin and HLA class I antigen down-regulation in primary maxillary sinus squamous cell carcinoma lesions with reduced survival of patients.

2003 • 83 citations

Expression of HLA class I molecules and the transporter associated with antigen processing in hepatocellular carcinoma

1996 • 80 citations

Signal transduction abnormalities in T lymphocytes from patients with advanced renal carcinoma: clinical relevance and effects of cytokine therapy.

1998 • 77 citations

Downregulation of JAK3 Protein Levels in T Lymphocytes by Prostaglandin E2 and Other Cyclic Adenosine Monophosphate-Elevating Agents: Impact on Interleukin-2 Receptor Signaling Pathway

1999 • 72 citations

T cells from patients with Hodgkin's disease have a defective T-cell receptor zeta chain expression that is reversible by T-cell stimulation with CD3 and CD28

1996 • 71 citations

Alterations in NF kappa B/Rel family proteins in splenic T-cells from tumor-bearing mice and reversal following therapy.

1994 • 70 citations

Downregulation of the proteasome subunits, transporter, and antigen presentation in hepatocellular carcinoma, and their restoration by interferon‐γ

2002 • 70 citations

Lack of HLA‐class I antigens in human neuroblastoma cells: analysis of its relationship to TAP and tapasin expression

2001 • 70 citations

The susceptibility to natural killer cell-mediated lysis of HLA class I-positive melanomas reflects the expression of insufficient amounts of different HLA class I alleles

1998 • 67 citations

Downregulation of the constitutive tapasin expression in human tumor cells of distinct origin and its transcriptional upregulation by cytokines

2001 • 66 citations

To DRiP or not to DRiP: generating peptide ligands for MHC class I molecules from biosynthesized proteins

2002 • 66 citations

Altered protein tyrosine phosphorylation in anergic Th1 cells.

1993 • 65 citations

Reduction in susceptibility to natural killer cell-mediated lysis of human FO-1 melanoma cells after induction of HLA class I antigen expression by transfection with B2m gene.

1991 • 65 citations

Variable expression of CD3‐zeta and associated protein tyrosine kinases in lymphocytes from patients with myeloid malignancies

1998 • 64 citations

HLA class I antigen cell surface expression is preserved on acute myeloid leukemia blasts at diagnosis and at relapse

2001 • 58 citations

Locus-Specific Analysis of Human Leukocyte Antigen Class I Expression in Melanoma Cell Lines

1994 • 55 citations

High Frequency of Cancer Patients with Abnormal Assembly of the T Cell Receptor‐CD3 Complex in Peripheral Blood T Lymphocytes

1994 • 52 citations

Antitumor effects of interleukin 2 liposomes and anti-CD3-stimulated T-cells against murine MCA-38 hepatic metastasis.

1991 • 50 citations

Deficient tumor-infiltrating T-lymphocyte response in malignant lymphoma: relationship to HLA expression and host immunocompetence.

1993 • 49 citations

Prognostic Value of Host Immunocompetence in Urologic Cancer Patients

1975 • 43 citations

The antigen processing machinery of class I human leukocyte antigens: linked patterns of gene expression in neoplastic cells.

2003 • 42 citations

Lymphocyte subset infiltration patterns and HLA antigen status in colorectal carcinomas and adenomas.

1996 • 41 citations

Investigation of HLA class I downregulation in breast cancer by RT-PCR

2001 • 41 citations

Reciprocal regulation of plasmacytoid dendritic cells and monocytes during viral infection

2001 • 40 citations

The structure and signalling functions of the invariant T cell receptor components.

1990 • 40 citations

Specificity of the T Cells That Mediate and Suppress Adoptive Immunotherapy of Established Tumors

1984 • 40 citations

Impediments to Successful Immunotherapy

1999 • 40 citations

β₂‐microglobulin aberrations in diffuse large B‐cell lymphoma of the testis and the central nervous system

2002 • 40 citations

MHC class I negative phenotype of disseminated tumor cells in bone marrow is associated with poor survival in R0M0 breast cancer patients

2001 • 39 citations

Phenotypic expression of histocompatibility antigens in human primary tumours and metastases

1989 • 37 citations

Active Repression of Major Histocompatibility Complex Class I Genes in a Human Neuroblastoma Cell Line

1996 • 36 citations

Characterization of antigen processing machinery and Survivin expression in tonsillar squamous cell carcinoma

2003 • 35 citations

HLA class I expression in bladder carcinomas

2003 • 35 citations

Mutation in the β2m gene is not a frequent event in head and neck squamous cell carcinomas

1999 • 34 citations

Correlation between disease activity and T‐cell CD3 chain expression in a B‐cell lymphoma

1994 • 33 citations

Molecular Regulation of Cytokine Gene Expression: lnterferon-γ as a Model System

1997 • 32 citations

Expression of class I histocompatibility antigens in transitional cell carcinoma of the urinary bladder in relation to survival

1991 • 29 citations

Restoration of expression of signal-transduction molecules in lymphocytes from patients with metastatic renal cell cancer after combination immunotherapy

1999 • 28 citations

LY-1+2- SUPPRESSOR T CELLS INHIBIT THE EXPRESSION OF PASSIVELY TRANSFERRED ANTITUMOR IMMUNITY BY SUPPRESSING THE GENERATION OF CYTOLYTIC T CELLS

1985 • 27 citations

Mechanisms of allele‐selective down‐regulation of HLA class I in Burkitt's lymphoma

1995 • 27 citations

A nucleotide insertion in exon 4 is responsible for the absence of expression of an HLA-A*0301 allele in a prostate carcinoma cell line

2001 • 26 citations

Suppressive Effects of Visceral Tumor on the Generation of Antitumor T Cells for Adoptive Immunotherapy

1991 • 25 citations

The Expression of HLA Class I Antigens in Germ Cell Testicular Cancer

1990 • 24 citations

CD80 expression in an HLA-A2-positive human non-small cell lung cancer cell line enhances tumor-specific cytotoxicity of HLA-A2-positive T cells derived from a normal donor and a patient with non-small cell lung cancer

1998 • 22 citations

In Vitro Suppression of Immunocompetent Cells by Lymphomas From Aging Mice 2

1975 • 22 citations

Development of immunogenic colorectal cancer cell lines for vaccination: Expression of CD80 (B7.1) is not sufficient to restore impaired primary T cell activation in vitro

1995 • 21 citations

Loss of single HLA Class I allospecificities in melanoma cells due to selective genomic abbreviations

2002 • 20 citations

HLA-B locus-specific downregulation in human melanoma requires enhancer A as well as a sequence element located downstream of the transcription initiation site

2000 • 19 citations

The expression of HLA class I antigen in prostate cancer in relation to tumor differentiation and patient survival.

1994 • 19 citations

β2-microglobulin gene mutation is not a common mechanism of HLA class I total loss in human tumors

2000 • 19 citations

HLA molecule expression in cutaneous squamous cell carcinomas: an immunopathological study and clinical-immunohistopathological correlations.

1993 • 19 citations

HLA class I antigens expression in renal cell carcinoma: histopathological and clinical correlation.

1999 • 16 citations

HLA class I antigen downregulation by interleukin (IL)‐10 is predominantly governed by NF‐κB in the short term and by TAP1+2 in the long term

2000 • 15 citations

Cloning and proliferating precursor frequencies of tumor-infiltrating lymphocytes from human solid tumors.

1988 • 14 citations

Bacterial vaccine therapy of cancer.

1977 • 13 citations

Reduced Recognition of Metastatic Melanoma Cells by Autologous MART-1 Specific CTL: Relationship to TAP Expression

2000 • 12 citations

Major histocompatibility complex class I and class II antigen expression in diffuse large cell and large cell immunoblastic lymphomas. Absence of a correlation between antigen expression and clinical outcome.

1993 • 11 citations

c-erbB-2 and Episialin Challenge Host Immune Response by HLA Class I Expression in Human Non–Small-Cell Lung Cancer

2000 • 11 citations

HLA class I and class II expression of pulmonary adenocarcinoma cells and the influence of interferon gamma

1998 • 11 citations

Frequency and genetic basis of MHC, beta‐2‐microglobulin and MEMO‐1 loss of heterozygosity in sporadic breast cancer

2002 • 10 citations

Mechanism of suppression of the depressed lymphocyte response in lung cancer patients.

1985 • 10 citations

Introduction

2002 • 8 citations

The regulation of T-cell antigen receptor signal transduction function.

1991 • 8 citations

The Activation of T Lymphocytes

1987 • 8 citations

Comparison of Cytokines and CD8O for Enhancement of lmmunogenicity of Cervical Cancer Cells

2000 • 7 citations

HLA class I antigen expression in human solid tumors.

1996 • 4 citations

? 2 -microglobulin gene mutation is not a common mechanism of HLA class I total loss in human tumors

2000 • 2 citations