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Chemical chaperones protect from effects of apoptosis-inducing mutation in carbonic anhydrase IV identified in retinitis pigmentosa 17

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The Effect of Very-Low-Calorie Diet on mRNA Expression of Inflammation-Related Genes in Subcutaneous Adipose Tissue and Peripheral Monocytes of Obese Patients with Type 2 Diabetes Mellitus

2011 • 74 citations

Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3–TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study

2013 • 74 citations

Endoplasmic Reticulum Stress Induces the Expression of Fetuin-A to Develop Insulin Resistance

2012 • 74 citations

Marked acceleration of exogenous fatty acid incorporation into cellular triglycerides by fetuin.

1990 • 72 citations

A genetic basis for the “Adonis” phenotype of low adiposity and strong bones

2004 • 72 citations

Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic islets

2011 • 68 citations

Pioglitazone, a PPAR-γ ligand, provides protection from dextran sulfate sodium-induced colitis in mice in association with inhibition of the NF-κB-cytokine cascade

2002 • 66 citations

Defective Regulation of the Ubiquitin/Proteasome System in the Hypothalamus of Obese Male Mice

2014 • 66 citations

Persistent Activation of Phosphatidylinositol 3-Kinase Causes Insulin Resistance Due to Accelerated Insulin-Induced Insulin Receptor Substrate-1 Degradation in 3T3-L1 Adipocytes*

2000 • 66 citations

Defective Insulin and Acetylcholine Induction of Endothelial Cell–Nitric Oxide Synthase Through Insulin Receptor Substrate/Akt Signaling Pathway in Aorta of Obese Rats

2007 • 65 citations

TNF-α transiently induces endoplasmic reticulum stress and an incomplete unfolded protein response in the hypothalamus

2010 • 62 citations

Regulation of insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and dexamethasone.

1994 • 61 citations

Deficiency in TLR4 signal transduction ameliorates cardiac injury and cardiomyocyte contractile dysfunction during ischemia

2009 • 61 citations

Short-term periodic consumption of multiprobiotic from childhood improves insulin sensitivity, prevents development of non-alcoholic fatty liver disease and adiposity in adult rats with glutamate-induced obesity

2014 • 60 citations

Small-Molecule Inhibitors of PKR Improve Glucose Homeostasis in Obese Diabetic Mice

2013 • 60 citations

Toll-like receptor 4 and inducible nitric oxide synthase gene polymorphisms are associated with Type 2 diabetes

2009 • 56 citations

Endotoxin-inducible cytotoxicity in liver cell cultures—I

1991 • 56 citations

Aspirin attenuates insulin resistance in muscle of diet-induced obese rats by inhibiting inducible nitric oxide synthase production and S-nitrosylation of IRβ/IRS-1 and Akt

2009 • 54 citations

A Treasure Trove of Hypothalamic Neurocircuitries Governing Body Weight Homeostasis

2010 • 50 citations

Toll-like receptor 4 polymorphisms and their haplotypes modulate the risk of developing diabetic retinopathy in type 2 diabetes patients.

2014 • 50 citations

Biochemical fractionation and assembly of the membrane components that mediate nascent chain targeting and translocation

1991 • 50 citations

Sex-Specific Association of Fetuin-A With Type 2 Diabetes in Older Community-Dwelling Adults

2013 • 48 citations

PLASMA-INSULIN AND INSULIN RESISTANCE

1957 • 48 citations

TLR4 gene polymorphisms: evidence for protection against type 2 diabetes but not for diabetes-associated ischaemic heart disease

2011 • 46 citations

Enteric microbiota leads to new therapeutic strategies for ulcerative colitis

2014 • 46 citations

Protein kinase C isoforms ɛ, η, δ and ζ in murine adipocytes: expression, subcellular localization and tissue-specific regulation in insulin-resistant states

1996 • 42 citations

Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice

2013 • 40 citations

Chaperone Insufficiency Links TLR4 Protein Signaling to Endoplasmic Reticulum Stress

2012 • 40 citations

S6K1 Negatively Regulates TAK1 Activity in the Toll-Like Receptor Signaling Pathway

2013 • 40 citations

Toll-like receptor 2 and 4 stimulation elicits an enhanced inflammatory response in human obese patients with atherosclerosis

2011 • 37 citations

Binding, Internalization, and Degradation of Insulin in Vascular Endothelial Cells

1982 • 37 citations

TLR4 Expression in Bone Marrow-Derived Cells Is Both Necessary and Sufficient to Produce the Insulin Resistance Phenotype in Diet-Induced Obesity

2014 • 36 citations

Coordinated Defects in Hepatic Long Chain Fatty Acid Metabolism and Triglyceride Accumulation Contribute to Insulin Resistance in Non-Human Primates

2011 • 35 citations

Increased Toll‐like receptor (<scp>TLR</scp>) <scp>mRNA</scp> expression in monocytes is a feature of metabolic syndrome in adolescents

2012 • 35 citations

Insulin Deficiency and Insulin Inefficiency

1940 • 32 citations

Toll-like receptor 4 signaling is required for induction of gluconeogenic gene expression by palmitate in human hepatic carcinoma cells

2013 • 31 citations

Low frequency of Toll‐like receptors 2 and 4 gene polymorphisms in Mexican patients and their association with Type 2 diabetes

2011 • 31 citations

The D299G/T399I Toll-Like Receptor 4 Variant Associates with Body and Liver Fat: Results from the TULIP and METSIM Studies

2010 • 28 citations

The Therapeutic Potential of Allosteric Ligands for Free Fatty Acid Sensitive GPCRs

2013 • 27 citations

A designed TLR4/MD-2 complex to capture LPS

2005 • 26 citations

Loss of Toll-like Receptor 2 and 4 Leads to Differential Induction of Endoplasmic Reticulum Stress and Proapoptotic Responses in the Intestinal Epithelium under Conditions of Chronic Inflammation

2009 • 24 citations

A designed TLR4/MD-2 complex to capture LPS

2005 • 20 citations

The functional Toll-like receptor 4 Asp299Gly polymorphism is associated with lower left ventricular mass in hypertensive women

2010 • 17 citations

Knockdown of RyR3 Enhances Adiponectin Expression Through an atf3-Dependent Pathway

2013 • 17 citations

Insulin Resistance and Sensitivity

1940 • 10 citations

Point Aa of the POP-Q system as a predictive value of urethral mobility in women

2010 • 9 citations

A CASE OF POSTERIOR BASAL MENINGITIS WITH FEW CEREBRAL SYMPTOMS

1906 • 9 citations

Gpr120 agonist has anti-inflammatory and insulin-sensitizing effects

2014 • 8 citations

A 10-Patient Case Study on the Influence of Two Different Probiotics on Individual Intestinal Microbiota

2014 • 6 citations

Deleted Work

1955 • 0 citations