Toll-like receptor 2 deficiency improves insulin sensitivity and hepatic insulin signalling in the mouse

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

Inflammation and insulin resistance

2006 • 4,264 citations

Toll-like receptors and innate immunity

2001 • 4,138 citations

Inflammation, stress, and diabetes

2005 • 3,786 citations

TLR4 links innate immunity and fatty acid–induced insulin resistance

2006 • 3,422 citations

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

1999 • 3,351 citations

A central role for JNK in obesity and insulin resistance

2002 • 3,225 citations

Obesity and insulin resistance

2000 • 3,076 citations

Critical nodes in signalling pathways: insights into insulin action

2006 • 2,581 citations

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

2005 • 2,161 citations

Adipocytes as regulators of energy balance and glucose homeostasis

2006 • 2,075 citations

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

2001 • 1,849 citations

Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors

1999 • 1,679 citations

The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307

2000 • 1,423 citations

Inflammation, stress, and diabetes

2005 • 1,203 citations

A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways

2007 • 972 citations

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

2004 • 862 citations

Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.

1998 • 843 citations

Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance

2007 • 823 citations

Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex

2002 • 742 citations

Prevention of fat-induced insulin resistance by salicylate

2001 • 713 citations

Weight and blood pressure. Findings in hypertension screening of 1 million Americans

1978 • 676 citations

Circulating Mononuclear Cells in the Obese Are in a Proinflammatory State

2004 • 603 citations

Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox

2007 • 590 citations

Mammalian Toll-like receptors

2003 • 589 citations

Toll-Like Receptor-4 Mediates Vascular Inflammation and Insulin Resistance in Diet-Induced Obesity

2007 • 551 citations

Inflammation and the IKKβ/IκB/NF-κB axis in obesity- and diet-induced insulin resistance

2003 • 447 citations

Isolation, Structure Elucidation, and Synthesis of a Macrophage Stimulatory Lipopeptide from Mycoplasma fermentans Acting at Picomolar Concentration

1997 • 407 citations

Weight and Blood Pressure

1978 • 405 citations

JNK and Tumor Necrosis Factor-α Mediate Free Fatty Acid-induced Insulin Resistance in 3T3-L1 Adipocytes

2005 • 396 citations

The Lipopolysaccharide-activated Toll-like Receptor (TLR)-4 Induces Synthesis of the Closely Related Receptor TLR-2 in Adipocytes

2000 • 348 citations

C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet

2007 • 342 citations

Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation and Function by Mitogen-activated Protein Kinase

1997 • 300 citations

Phosphorylation of Insulin Receptor Substrate-1 on Multiple Serine Residues, 612, 632, 662, and 731, Modulates Insulin Action

1996 • 255 citations

Toll-like Receptor-2 Is Essential for the Development of Palmitate-induced Insulin Resistance in Myotubes

2006 • 254 citations

TLR1- and TLR6-independent Recognition of Bacterial Lipopeptides

2006 • 247 citations

Endotoxin Stimulates In Vivo Expression of Inflammatory Cytokines Tumor Necrosis Factor Alpha, Interleukin-1??, -6, and High-Mobility-Group Protein-1 in Skeletal Muscle

2003 • 210 citations

Modulation of Insulin-stimulated Degradation of Human Insulin Receptor Substrate-1 by Serine 312 Phosphorylation

2003 • 202 citations

Tlr2 is critical for diet‐induced metabolic syndrome in a murine model

2009 • 180 citations

Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet

2008 • 137 citations

Palmitate-Induced Interleukin 6 Production Is Mediated by Protein Kinase C and Nuclear-Factor κB Activation and Leads to Glucose Transporter 4 Down-Regulation in Skeletal Muscle Cells

2005 • 136 citations

Weight and Blood Pressure

1948 • 119 citations

Lipopeptide structure determines TLR2 dependent cell activation level

2005 • 105 citations

Involvement of Leucine Residues at Positions 107, 112, and 115 in a Leucine-Rich Repeat Motif of Human Toll-Like Receptor 2 in the Recognition of Diacylated Lipoproteins and Lipopeptides and Staphylococcus aureus Peptidoglycans

2003 • 95 citations

Fat fuels insulin resistance through Toll-like receptors

2006 • 40 citations

High fat intake induces a population of adipocytes to co-express TLR2 and TNFα in mice with insulin resistance

2007 • 35 citations