The inflammatory status score including IL-6, TNF-α, osteopontin, fractalkine, MCP-1 and adiponectin underlies whole-body insulin resistance and hyperglycemia in type 2 diabetes mellitus
Data up to Jan 2025
Total Citations Per Year
Abstract
References (47)
Obesity is associated with macrophage accumulation in adipose tissue
2003 • 8,349 citations
Inflammation and metabolic disorders
2006 • 8,000 citations
Obesity is associated with macrophage accumulation in adipose tissue
2003 • 7,795 citations
Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
2008 • 6,182 citations
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
2003 • 5,744 citations
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
2003 • 5,391 citations
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
2001 • 4,874 citations
Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
2012 • 3,964 citations
Rosuvastatin to Prevent Vascular Events in Men and Women With Elevated C-Reactive Protein
2009 • 3,737 citations
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
2001 • 2,534 citations
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
2006 • 2,496 citations
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
2009 • 2,335 citations
Inflammatory Cytokine Concentrations Are Acutely Increased by Hyperglycemia in Humans
2002 • 1,839 citations
Tumor necrosis factor alpha inhibits signaling from the insulin receptor.
1994 • 1,173 citations
Inflammatory Markers and the Risk of Coronary Heart Disease in Men and Women
2004 • 1,145 citations
Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets
2002 • 946 citations
Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1
2010 • 897 citations
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
2010 • 840 citations
Increased Number of Islet-Associated Macrophages in Type 2 Diabetes
2007 • 734 citations
Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters
2006 • 481 citations
Metformin Inhibits Proinflammatory Responses and Nuclear Factor-κB in Human Vascular Wall Cells
2005 • 459 citations
Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice
2007 • 372 citations
The effect of metformin on blood pressure, plasma cholesterol and triglycerides in type 2 diabetes mellitus: a systematic review
2004 • 350 citations
Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity
2008 • 293 citations
Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complications
2009 • 292 citations
Insulin resistance and inflammation in an evolutionary perspective: the contribution of cytokine genotype/phenotype to thriftiness
1999 • 253 citations
Effects of short‐term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo‐controlled trial
2004 • 218 citations
A Unique Role of Monocyte Chemoattractant Protein 1 among Chemokines in Adipose Tissue of Obese Subjects
2005 • 199 citations
Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway
2009 • 176 citations
Pancreatic islet amyloidosis, β-cell apoptosis, and α-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons
2009 • 160 citations
Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetes.
1993 • 152 citations
Prevalence and correlates of post-prandial hyperglycaemia in a large sample of patients with type 2 diabetes mellitus
2006 • 144 citations
TIMP3 Is Reduced in Atherosclerotic Plaques From Subjects With Type 2 Diabetes and Increased by SirT1
2009 • 142 citations
Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice
2013 • 135 citations
Decreased carotid atherosclerotic process by control of daily acute glucose fluctuations in diabetic patients treated by DPP-IV inhibitors
2013 • 122 citations
Circulating Leptin Correlates with Left Ventricular Mass in Morbid (Grade III) Obesity before and after Weight Loss Induced by Bariatric Surgery: A Potential Role for Leptin in Mediating Human Left Ventricular Hypertrophy
2005 • 116 citations
Type 2 diabetes mellitus—an autoimmune disease?
2013 • 112 citations
Impaired regulation of the TNF-α converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans
2009 • 92 citations
The influence of improved glycaemic control with insulin and sulphonylureas on acute phase and endothelial markers in Type II Diabetic subjects
2000 • 88 citations
Increased Skeletal Muscle Tumor Necrosis Factor-α and Impaired Insulin Signaling Persist in Obese Women With Gestational Diabetes Mellitus 1 Year Postpartum
2007 • 85 citations
Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3–TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study
2013 • 74 citations
Changes in Inflammatory Cytokines Are Related to Impaired Glucose Tolerance in Offspring of Type 2 Diabetic Subjects
2006 • 72 citations
Proteomics Reveals Novel Oxidative and Glycolytic Mechanisms in Type 1 Diabetic Patients' Skin Which Are Normalized by Kidney-Pancreas Transplantation
2010 • 69 citations
Osteopontin: a novel inflammatory mediator of cardiovascular disease
2006 • 58 citations
Markers of endothelial dysfunction and low-grade inflammation are associated in the offspring of type 2 diabetic subjects
2007 • 38 citations
Validation of a novel index to assess insulin resistance of adipose tissue lipolytic activity in obese subjects
2011 • 35 citations
Lack of association of apoE ε4 allele with insulin resistance
2011 • 12 citations