Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

1993 • 7,219 citations

The insulin signaling system.

1994 • 1,733 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

1994 • 1,173 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Insulin Resistance — Mechanisms, Syndromes, and Implications

1991 • 788 citations

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1985 • 665 citations

Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates.

1993 • 543 citations

Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output.

1992 • 493 citations

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.

1992 • 471 citations

Metabolic Disturbances and Wasting in the Acquired Immunodeficiency Syndrome

1992 • 402 citations

IRS-1: Essential for Insulin- and IL-4-Stimulated Mitogenesis in Hematopoietic Cells

1993 • 401 citations

Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance.

1994 • 371 citations

Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha.

1991 • 369 citations

Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance.

1992 • 328 citations

Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity.

1991 • 311 citations

Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.

1992 • 263 citations

Through thick and thin: Wasting, obesity, and TNFα

1993 • 223 citations

A review of cancer cachexia and abnormal glucose metabolism in humans with cancer.

1992 • 195 citations

Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output

1992 • 162 citations

Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice.

1993 • 115 citations

The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. Analysis with insulin and anti-receptor antibodies.

1992 • 107 citations

Insulin resistance in patients with colorectal cancer

1987 • 88 citations

Insulin-Receptor Autophosphorylation and Endogenous Substrate Phosphorylation in Human Adipocytes From Control, Obese, and NIDDM Subjects

1990 • 79 citations

Divergent regulation of the Glut 1 and Glut 4 glucose transporters in isolated adipocytes from Zucker rats.

1992 • 74 citations

Monokine regulation of glucose transporter mRNA in L6 myotubes

1989 • 43 citations

Peptide hormone action: A practical approach

1991 • 42 citations

Insulin-receptor autophosphorylation and endogenous substrate phosphorylation in human adipocytes from control, obese, and NIDDM subjects

1990 • 29 citations