MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

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2003 • 8,349 citations

Obesity is associated with macrophage accumulation in adipose tissue

2003 • 7,795 citations

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

1993 • 7,219 citations

Central nervous system control of food intake

2000 • 6,305 citations

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2003 • 5,744 citations

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2003 • 5,391 citations

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2006 • 3,422 citations

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2002 • 3,225 citations

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

2003 • 3,104 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

1997 • 2,190 citations

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2000 • 2,178 citations

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

2005 • 2,161 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

Unresponsiveness of MyD88-Deficient Mice to Endotoxin

1999 • 2,088 citations

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

1998 • 2,047 citations

IKK-β links inflammation to obesity-induced insulin resistance

2005 • 1,710 citations

TLR signaling

2006 • 1,652 citations

Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

1995 • 1,630 citations

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

2008 • 1,261 citations

Sniffing neuropeptides: a transnasal approach to the human brain

2002 • 1,243 citations

Saturated Fatty Acids, but Not Unsaturated Fatty Acids, Induce the Expression of Cyclooxygenase-2 Mediated through Toll-like Receptor 4

2001 • 1,241 citations

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

1998 • 1,173 citations

Consumption of a Fat-Rich Diet Activates a Proinflammatory Response and Induces Insulin Resistance in the Hypothalamus

2005 • 1,099 citations

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

1979 • 1,089 citations

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

2009 • 1,031 citations

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

1999 • 1,000 citations

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

2000 • 873 citations

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2002 • 852 citations

Diabetes, Obesity, and the Brain

2005 • 840 citations

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

2009 • 836 citations

Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance

2007 • 823 citations

Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production

2007 • 650 citations

The Role of SOCS-3 in Leptin Signaling and Leptin Resistance

1999 • 640 citations

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

2004 • 632 citations

Neuronal PTP1B regulates body weight, adiposity and leptin action

2006 • 603 citations

Role for neuronal insulin resistance in neurodegenerative diseases

2004 • 601 citations

The role of insulin receptor signaling in the brain

2005 • 584 citations

Palmitate-induced Apoptosis Can Occur through a Ceramide-independent Pathway

2001 • 575 citations

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

2008 • 552 citations

Toll-Like Receptor-4 Mediates Vascular Inflammation and Insulin Resistance in Diet-Induced Obesity

2007 • 551 citations

Inflammation and the IKKβ/IκB/NF-κB axis in obesity- and diet-induced insulin resistance

2003 • 447 citations

Central insulin action in energy and glucose homeostasis

2006 • 429 citations

A universal role for MyD88 in TLR/IL-1R-mediated signaling

2002 • 383 citations

Leptin actions on food intake and body temperature are mediated by IL-1

1999 • 364 citations

C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet

2007 • 342 citations

Tlr‐4 Deficiency Selectively Protects Against Obesity Induced by Diets High in Saturated Fat

2008 • 318 citations

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity

2006 • 307 citations

Central insulin action regulates peripheral glucose and fat metabolism in mice

2008 • 263 citations

Toll-like Receptor-2 Is Essential for the Development of Palmitate-induced Insulin Resistance in Myotubes

2006 • 254 citations

Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells

2006 • 241 citations

Downregulation of Diacylglycerol Kinase Delta Contributes to Hyperglycemia-Induced Insulin Resistance

2008 • 222 citations

Serine Phosphorylation and Negative Regulation of Stat3 by JNK

1999 • 219 citations

Leptin Rapidly Lowers Food Intake and Elevates Metabolic Rates in Lean and ob/ob Mice ,

1997 • 191 citations

PDK1 Deficiency in POMC-Expressing Cells Reveals FOXO1-Dependent and -Independent Pathways in Control of Energy Homeostasis and Stress Response

2008 • 160 citations

Central Administration of an Endoplasmic Reticulum Stress Inducer Inhibits the Anorexigenic Effects of Leptin and Insulin

2009 • 144 citations

Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet

2008 • 137 citations

Hepatic NF-κB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis

2008 • 102 citations

Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance

2004 • 97 citations

Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance

2004 • 78 citations

Mice with deletion of the mitochondrial glycerol-3-phosphate dehydrogenase gene exhibit a thrifty phenotype: effect of gender

2004 • 32 citations

Gender difference in the leptin response to feeding in peroxisome-proliferator-activated receptor-alpha knockout mice

2002 • 17 citations

Central interleukin-1 (IL1) signaling is required for pharmacological, but not physiological, effects of leptin on energy balance

2007 • 14 citations