Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

1996 • 3,854 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Structure and Function of Lipopolysaccharide Binding Protein

1990 • 1,689 citations

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

1998 • 1,218 citations

Identity of tumour necrosis factor and the macrophage-secreted factor cachectin

1985 • 1,125 citations

Resistance to Endotoxin Shock and Reduced Dissemination of Gram-Negative Bacteria in CD14-Deficient Mice

1996 • 760 citations

Trends in Infectious Diseases Mortality in the United States

1996 • 469 citations

Genetic Control of Leucocyte Responses to Endotoxin

1968 • 384 citations

Genetic and Physical Mapping of theLpsLocus: Identification of the Toll-4 Receptor as a Candidate Gene in the Critical Region

1998 • 372 citations

Identification of a Lipid A Binding Site in the Acute Phase Reactant Lipopolysaccharide Binding Protein

1989 • 351 citations

Tumor Necrosis Factor: The molecules and Their Emerging Role in Medicine

1992 • 330 citations

Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14.

1993 • 302 citations

The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense

1997 • 277 citations

Lipopolysaccharide Signals Activation of Tumor Necrosis Factor Biosynthesis Through the Ras/Raf-1/MEK/MAPK Pathway

1994 • 228 citations

The Primary Role of Lymphoreticnlar Cells in the Mediation of Host Responses to Bacterial Endotoxim

1980 • 212 citations

Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide

1977 • 173 citations

Resistance to Salmonellosis in the Chicken Is Linked toNRAMP1and TNC

1997 • 144 citations

The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll

1994 • 141 citations

The Response of Recombinant Inbred Strains of Mice to Bacterial Lipopolysaccharides

1977 • 138 citations

Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice

1978 • 130 citations

Endotoxin and IL-1 hyporesponsiveness in a patient with recurrent bacterial infections.

1997 • 101 citations

Lipopolysaccharide (LPS) recognition in macrophages. Participation of LPS-binding protein and CD14 in LPS-induced adaptation in rabbit peritoneal exudate macrophages.

1993 • 87 citations

Characterization of a Congenitally LPS-Resistant, Athymic Mouse Strain

1979 • 85 citations

Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila

1994 • 40 citations

Genetic Analysis of Generation of Serum Interferon by Bacterial Lipopolysaccharide

1977 • 35 citations

Action of Endotoxin on Lymphoid Cells

1977 • 25 citations

Book Received

1980 • 1 citations