Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

After Insulin Binds

1987 • 687 citations

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1985 • 665 citations

Activation of phosphatidylinositol 3-kinase by insulin.

1990 • 531 citations

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.

1987 • 399 citations

The Disposal of an Oral Glucose Load in Healthy Subjects: A Quantitative Study

1985 • 397 citations

Expression and function of IRS-1 in insulin signal transmission.

1992 • 331 citations

Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance.

1992 • 328 citations

Effect of dexamethasone on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes.

1975 • 275 citations

Phosphatidylinositol kinase or an associated protein is a substrate for the insulin receptor tyrosine kinase.

1990 • 266 citations

Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.

1992 • 263 citations

Alterations in Insulin Binding Induced by Changes in Vivo in the Levels of Glucocorticoids and Growth Hormone*

1978 • 246 citations

Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus.

1993 • 220 citations

Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase

1991 • 198 citations

The effects of acute and chronic dexamethasone administration on insulin binding to isolated rat hepatocytes and adipocytes

1975 • 150 citations

Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation.

1992 • 148 citations

Effects of glucocorticoids on muscle protein turnover in perfused rat hemicorpus

1980 • 148 citations

Phosphatidylinositol-3-kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution.

1992 • 137 citations

Glucocorticoid-induced Insulin Resistance

1982 • 125 citations

Purification of the catalytically active phosphorylated form of insulin receptor kinase by affinity chromatography with O-phosphotyrosyl-binding antibodies

1985 • 124 citations

The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth.

1990 • 107 citations

The disposal of an oral glucose load in healthy subjects. A quantitative study

1985 • 104 citations

Effects of adenosine cyclic monophosphate, dexamethasone, and insulin on phosphoenolpyruvate carboxykinase synthesis in Reuber H-35 hepatoma cells

1975 • 89 citations

Cellular mechanisms in selected states of insulin resistance: Human obesity, glucocorticoid excess, and chronic renal failure

1985 • 84 citations

PEPCK Gene as Model of Inhibitory Effects of Insulin on Gene Transcription

1990 • 83 citations

Insulin receptors with defective tyrosine kinase inhibit normal receptor function at the level of substrate phosphorylation.

1988 • 82 citations

Role of Glucose Transporters in Glucocorticoid-Induced Insulin Resistance: GLUT4 Isoform in Rat Skeletal Muscle is Not Decreased by Dexamethasone

1992 • 76 citations

Mechanism of glucocorticoid-induced increase in insulin receptors of cultured human lymphocytes.

1982 • 72 citations

Dexamethasone stimulates insulin receptor synthesis in cultured rat hepatocytes.

1983 • 65 citations

Mutations in the Juxtamembrane Region of the Insulin Receptor Impair Activation of Phosphatidylinositol 3-Kinase by Insulin

1991 • 49 citations

Effects of prednisolone and dexamethasone in vivo and in vitro: Studies of insulin binding, deoxyglucose uptake and glucose oxidation in rat adipocytes

1981 • 47 citations

Effects of hypercortisolemia and diabetes on skeletal muscle insulin receptor function in vitro and in vivo

1989 • 47 citations

Immunological Detection of Phosphotyrosine-Containing Proteins in Rat Livers After Insulin Injection

1990 • 35 citations

Dexamethasone-Induced Changes in Phosphorylation of the Insulin and Epidermal Growth Factor Receptors and Their Substrates in Intact Rat Hepatocytes*

1988 • 30 citations

The acute and chronic effects of glucocorticoids on insulin receptor and insulin responsiveness. Transient fluctuations in intracellular receptor level parallel transient fluctuations in responsiveness.

1986 • 26 citations

Intact Adipocyte Insulin-Receptor Phosphorylation and In Vitro Tyrosine Kinase Activity in Animal Models of Insulin Resistance

1988 • 25 citations

Role of glucose transporters in glucocorticoid-induced insulin resistance. GLUT4 isoform in rat skeletal muscle is not decreased by dexamethasone

1992 • 17 citations

Intact adipocyte insulin-receptor phosphorylation and in vitro tyrosine kinase activity in animal models of insulin resistance

1988 • 10 citations

Immunological detection of phosphotyrosine-containing proteins in rat livers after insulin injection

1990 • 8 citations