Obesity is associated with hypothalamic injury in rodents and humans

Obesity is associated with macrophage accumulation in adipose tissue

2003 • 8,349 citations

Obesity is associated with macrophage accumulation in adipose tissue

2003 • 7,795 citations

Central nervous system control of food intake

2000 • 6,305 citations

Inflammation and insulin resistance

2006 • 4,264 citations

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

2011 • 3,574 citations

Microglia: active sensor and versatile effector cells in the normal and pathologic brain

2007 • 3,382 citations

Central nervous system control of food intake and body weight

2006 • 2,374 citations

Molecular dissection of reactive astrogliosis and glial scar formation

2009 • 2,343 citations

Inflammatory links between obesity and metabolic disease

2011 • 2,081 citations

Microglial Physiology: Unique Stimuli, Specialized Responses

2009 • 1,693 citations

Tripartite synapses: astrocytes process and control synaptic information

2009 • 1,629 citations

Astrocyte activation and reactive gliosis

2005 • 1,513 citations

Microglia-specific localisation of a novel calcium binding protein, Iba1

1998 • 1,337 citations

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

2008 • 1,261 citations

Insulin sensitivity: modulation by nutrients and inflammation

2008 • 1,164 citations

Consumption of a Fat-Rich Diet Activates a Proinflammatory Response and Induces Insulin Resistance in the Hypothalamus

2005 • 1,099 citations

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

2009 • 1,031 citations

Mechanisms of Leptin Action and Leptin Resistance

2007 • 989 citations

Microglial Activation and its Implications in the Brain Diseases

2007 • 920 citations

Autophagy gone awry in neurodegenerative diseases

2010 • 867 citations

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

2009 • 836 citations

Obesity and leptin resistance: distinguishing cause from effect

2010 • 793 citations

Agouti-related peptide–expressing neurons are mandatory for feeding

2005 • 738 citations

Changing Face of Microglia

2010 • 575 citations

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

2008 • 552 citations

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

2009 • 460 citations

High-Fat Diet Induces Apoptosis of Hypothalamic Neurons

2009 • 404 citations

Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity

2010 • 400 citations

Heat-shock protein protection

1999 • 377 citations

Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance

2011 • 349 citations

Vascular Inflammation, Insulin Resistance, and Reduced Nitric Oxide Production Precede the Onset of Peripheral Insulin Resistance

2008 • 345 citations

Minireview: Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up

2010 • 288 citations

Brain MR: pathologic correlation with gross and histopathology. 2. Hyperintense white-matter foci in the elderly

1988 • 254 citations

Deep white matter infarction: correlation of MR imaging and histopathologic findings.

1988 • 239 citations

Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway

2011 • 236 citations

Hsp70 and Its Molecular Role in Nervous System Diseases

2011 • 228 citations

Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity

2010 • 213 citations

Autophagic Stress in Neuronal Injury and Disease

2006 • 210 citations

Hippocampal pathology in refractory temporal lobe epilepsy

2002 • 191 citations

Autophagy, inflammation and neurodegenerative disease

2010 • 87 citations

Expanding the definition of hypothalamic obesity

2010 • 86 citations

A Systems Biology Approach Identifies Inflammatory Abnormalities Between Mouse Strains Prior to Development of Metabolic Disease

2010 • 69 citations

Effects of chronic weight perturbation on energy homeostasis and brain structure in mice

2011 • 53 citations

Conflicting MRI signals from gliosis and neuronal vacuolation in prion diseases

1999 • 43 citations

Atypical Protein Kinase C Activity in the Hypothalamus Is Required for Lipopolysaccharide-Mediated Sickness Responses

2009 • 23 citations

Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up

2010 • 20 citations