Biochemical fractionation and assembly of the membrane components that mediate nascent chain targeting and translocation

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.

1975 • 3,026 citations

The Role of Polyamines in the Neutralization of Bacteriophage Deoxyribonucleic Acid

1960 • 2,598 citations

An hsp70-like protein in the ER: Identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein

1986 • 1,457 citations

Intracellular protein topogenesis

1980 • 1,378 citations

The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesis

1981 • 868 citations

Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.

1981 • 807 citations

Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum

1982 • 766 citations

[6] Preparation of microsomal membranes for cotranslational protein translocation

1983 • 679 citations

Secretory protein translocation across membranes—the role of the ‘docking protein’

1982 • 648 citations

Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein.

1981 • 644 citations

A protein-conducting channel in the endoplasmic reticulum

1991 • 613 citations

Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum.

1980 • 502 citations

Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor.

1982 • 478 citations

Protein disulfide isomerase: Multiple roles in the modification of nascent secretory proteins

1989 • 466 citations

Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle.

1982 • 388 citations

Trans‐membrane Translocation of Proteins

1979 • 364 citations

Purification of microsomal signal peptidase as a complex.

1986 • 313 citations

[3] Cell-free translation of messenger RNA in a wheat germ system

1983 • 301 citations

The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide

1989 • 293 citations

A signal sequence receptor in the endoplasmic reticulum membrane

1987 • 291 citations

Proteins of rough microsomal membranes related to ribosome binding. I. Identification of ribophorins I and II, membrane proteins characteristics of rough microsomes

1978 • 281 citations

Translocation of secretory proteins across the microsomal membrane occurs through an environment accessible to aqueous perturbants

1985 • 277 citations

Assembly of Proteins into Membranes

1980 • 255 citations

Formation of a functional ribosome-membrane junction during translocation requires the participation of a GTP-binding protein.

1986 • 199 citations

The signal recognition particle receptor is a complex that contains two distinct polypeptide chains.

1986 • 189 citations

Transient involvement of signal recognition particle and its receptor in the microsomal membrane prior to protein translocation

1983 • 160 citations

[53] Signal recognition particle: A ribonucleoprotein required for cotranslational translocation of proteins, isolation and properties

1983 • 155 citations

Proteins of rough microsomal membranes related to ribosome binding. II. Cross-linking of bound ribosomes to specific membrane proteins exposed at the binding sites

1978 • 142 citations

Characterization of secretory protein translocation: ribosome-membrane interaction in endoplasmic reticulum.

1986 • 121 citations

Assembly of translocation-competent proteoliposomes from detergent-solubilized rough microsomes

1990 • 118 citations

The signal sequence receptor has a second subunit and is part of a translocation complex in the endoplasmic reticulum as probed by bifunctional reagents.

1990 • 103 citations

On the translocation of proteins across membranes.

1987 • 95 citations

Reticuloplasmins: a novel group of proteins in the endoplasmic reticulum

1987 • 90 citations

Site-directed mutagenesis of cys148 in the lac carrier protein of Escherichia coli

1984 • 85 citations

Nascent secretory chain binding and translocation are distinct processes: differentiation by chemical alkylation.

1989 • 75 citations

cDNA-derived primary structure of the glycoprotein component of canine microsomal signal peptidase complex.

1988 • 67 citations

Structure and biosynthesis of the signal‐sequence receptor

1990 • 66 citations

Evidence for a two-step mechanism involved in assembly of functional signal recognition particle receptor.

1989 • 64 citations

A membrane component of the endoplasmic reticulum that may be essential for protein translocation.

1989 • 61 citations

[50] Ribophorins I and II: Membrane proteins characteristic of the rough endoplasmic reticulum

1983 • 23 citations

On the Translocation of Proteins Across Membranes

1987 • 5 citations