Pro-resolving lipid mediators are leads for resolution physiology

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

2010 • 3,439 citations

Resolution of inflammation: the beginning programs the end

2005 • 2,353 citations

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

2012 • 1,596 citations

Resolvins

2002 • 1,575 citations

The Human Serum Metabolome

2011 • 1,550 citations

Lipid mediator class switching during acute inflammation: signals in resolution

2001 • 1,355 citations

Novel Functional Sets of Lipid-Derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2–Nonsteroidal Antiinflammatory Drugs and Transcellular Processing

2000 • 1,136 citations

Resolvin E1 and protectin D1 activate inflammation-resolution programmes

2007 • 1,134 citations

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

2013 • 986 citations

Novel Docosatrienes and 17S-Resolvins Generated from Docosahexaenoic Acid in Murine Brain, Human Blood, and Glial Cells

2003 • 965 citations

Resolvins and Protectins in Inflammation Resolution

2011 • 896 citations

Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1

2005 • 890 citations

A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease

2005 • 828 citations

Novel Docosanoids Inhibit Brain Ischemia-Reperfusion-mediated Leukocyte Infiltration and Pro-inflammatory Gene Expression

2003 • 781 citations

Molecular Circuits of Resolution: Formation and Actions of Resolvins and Protectins

2005 • 672 citations

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

2009 • 657 citations

Why US Adults Use Dietary Supplements

2013 • 655 citations

Infection regulates pro-resolving mediators that lower antibiotic requirements

2012 • 592 citations

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

2010 • 538 citations

Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections

2012 • 536 citations

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

2012 • 529 citations

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

2012 • 483 citations

Anti-Inflammatory Actions of Neuroprotectin D1/Protectin D1 and Its Natural Stereoisomers: Assignments of Dihydroxy-Containing Docosatrienes

2006 • 432 citations

Resolvin E1 Regulates Inflammation at the Cellular and Tissue Level and Restores Tissue Homeostasis In Vivo

2007 • 431 citations

The Lipid Mediator Protectin D1 Inhibits Influenza Virus Replication and Improves Severe Influenza

2013 • 427 citations

RvE1 protects from local inflammation and osteoclastmediated bone destruction in periodontitis

2005 • 418 citations

Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators

2008 • 406 citations

Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases

2013 • 399 citations

Reduced Inflammation and Tissue Damage in Transgenic Rabbits Overexpressing 15-Lipoxygenase and Endogenous Anti-inflammatory Lipid Mediators

2003 • 392 citations

Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue

2014 • 385 citations

Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease

2013 • 354 citations

Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair

2009 • 346 citations

Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression

2006 • 343 citations

Protectin D1 Is Generated in Asthma and Dampens Airway Inflammation and Hyperresponsiveness

2007 • 333 citations

Resolution phase lipid mediators of inflammation: agonists of resolution

2013 • 305 citations

Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans

2009 • 298 citations

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

2011 • 274 citations

Transcriptomic analyses of murine resolution-phase macrophages

2011 • 273 citations

Resolution of Acute Inflammation in the Lung

2013 • 271 citations

Ligand-specific conformational change of the G-protein–coupled receptor ALX/FPR2 determines proresolving functional responses

2013 • 267 citations

Resolution of inflammation is altered in Alzheimer's disease

2014 • 260 citations

Resolvin E1 Receptor Activation Signals Phosphorylation and Phagocytosis

2009 • 257 citations

Resolvins D1, D2, and Other Mediators of Self-Limited Resolution of Inflammation in Human Blood following n-3 Fatty Acid Supplementation

2012 • 253 citations

Resolvin D1 Receptor Stereoselectivity and Regulation of Inflammation and Proresolving MicroRNAs

2012 • 252 citations

Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation

2012 • 252 citations

The novel 13S,14S‐epoxy‐maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A₄hydrolase (LTA₄H), and shifts macrophage phenotype

2013 • 243 citations

Rapid Appearance of Resolvin Precursors in Inflammatory Exudates: Novel Mechanisms in Resolution

2008 • 238 citations

Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development.

1996 • 234 citations

Peripheral gating of pain signals by endogenous lipid mediators

2014 • 233 citations

The Docosatriene Protectin D1 Is Produced by TH2 Skewing and Promotes Human T Cell Apoptosis via Lipid Raft Clustering

2005 • 231 citations

Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues.

1998 • 231 citations

Resolvin D1 Limits Polymorphonuclear Leukocyte Recruitment to Inflammatory Loci

2012 • 227 citations

Lipidomic Profiling of Influenza Infection Identifies Mediators that Induce and Resolve Inflammation

2013 • 226 citations

Lipoxins: resolutionary road

2009 • 224 citations

Resolving TRPV1- and TNF-α-Mediated Spinal Cord Synaptic Plasticity and Inflammatory Pain with Neuroprotectin D1

2011 • 222 citations

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Potent Immunoresolvents

2013 • 222 citations

Lipoxin A₄Analogues Inhibit Leukocyte Recruitment toPorphyromonas gingivalis: A Role for Cyclooxygenase-2 and Lipoxins in Periodontal Disease

2000 • 201 citations

The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats

2011 • 198 citations

Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC–MS/MS

2012 • 193 citations

Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing

2011 • 190 citations

A Novel Anti-Inflammatory and Pro-Resolving Role for Resolvin D1 in Acute Cigarette Smoke-Induced Lung Inflammation

2013 • 190 citations

Proresolution Therapy for the Treatment of Delayed Healing of Diabetic Wounds

2012 • 186 citations

The resolution of inflammation: the devil in the flask and in the details

2011 • 183 citations

Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing

2007 • 173 citations

Resolution of Inflammation in Murine Autoimmune Arthritis Is Disrupted by Cyclooxygenase-2 Inhibition and Restored by Prostaglandin E2-Mediated Lipoxin A4 Production

2010 • 171 citations

Augmentation of Myocardial Production of 15-Epi-Lipoxin-A ₄ by Pioglitazone and Atorvastatin in the Rat

2006 • 169 citations

Novel Proresolving Aspirin-Triggered DHA Pathway

2011 • 154 citations

Human inflammatory and resolving lipid mediator responses to resistance exercise and ibuprofen treatment

2013 • 149 citations

Role of Basic Science in the Development of New Medicines: Examples from the Eicosanoid Field

2012 • 143 citations

Aspirin‐triggered resolvin D1 prevents surgery‐induced cognitive decline

2013 • 139 citations

17(R)‐resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception

2011 • 136 citations

Controlling Herpes Simplex Virus-Induced Ocular Inflammatory Lesions with the Lipid-Derived Mediator Resolvin E1

2010 • 134 citations

Lethal Dissemination of H5N1 Influenza Virus Is Associated with Dysregulation of Inflammation and Lipoxin Signaling in a Mouse Model of Infection

2010 • 133 citations

Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in mice

2010 • 132 citations

Lipoxin A4 Increases Survival by Decreasing Systemic Inflammation and Bacterial Load in Sepsis

2011 • 131 citations

Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1

2010 • 131 citations

Specialized Proresolving Mediators Enhance Human B Cell Differentiation to Antibody-Secreting Cells

2012 • 128 citations

D‐series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury

2013 • 124 citations

Efficacy and safety of 15(R/S)-methyl-lipoxin A₄in topical treatment of infantile eczema

2012 • 123 citations

Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma

2012 • 122 citations

1α,25-Dihydroxyvitamin D3 and Resolvin D1 Retune the Balance between Amyloid-β Phagocytosis and Inflammation in Alzheimer's Disease Patients

2013 • 121 citations

Diversity of lipid mediators in human adipose tissue depots

2013 • 119 citations

Plasticity of Leukocytic Exudates in Resolving Acute Inflammation Is Regulated by MicroRNA and Proresolving Mediators

2013 • 118 citations

High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation

2013 • 117 citations

Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators

2013 • 116 citations

Self-Limited versus Delayed Resolution of Acute Inflammation: Temporal Regulation of Pro-Resolving Mediators and MicroRNA

2012 • 111 citations

Lipoxin A ₄ and benzo‐lipoxin A ₄ attenuate experimental renal fibrosis

2011 • 109 citations

Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke

2012 • 107 citations

Prostaglandins, bioassay and inflammation

2006 • 106 citations

Dichotomy in duration and severity of acute inflammatory responses in humans arising from differentially expressed proresolution pathways

2010 • 105 citations

Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms

2006 • 102 citations

A New Strategy for the Identification of Novel Molecules with Targeted Proresolution of Inflammation Properties

2009 • 101 citations

Proresolution Lipid Mediators in Multiple Sclerosis — Differential, Disease Severity-Dependent Synthesis — A Clinical Pilot Trial

2013 • 98 citations

Candida albicans Modulates Host Defense by Biosynthesizing the Pro-Resolving Mediator Resolvin E1

2007 • 97 citations

Resolvins E1 and D1 inhibit interstitial fibrosis in the obstructed kidney via inhibition of local fibroblast proliferation

2012 • 96 citations

A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation

2013 • 91 citations

Estrogen negatively regulates epithelial wound healing and protective lipid mediator circuits in the cornea

2011 • 88 citations

ATLa, an Aspirin-Triggered Lipoxin A4 Synthetic Analog, Prevents the Inflammatory and Fibrotic Effects of Bleomycin-Induced Pulmonary Fibrosis

2009 • 81 citations

Fish, Omega-3 and Human Health

2005 • 81 citations

Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions

2012 • 81 citations

Lipid mediators in immune dysfunction after severe inflammation

2013 • 80 citations

Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion

2013 • 77 citations

Resolvins E1 and D1 in Choroid-Retinal Endothelial Cells and Leukocytes: Biosynthesis and Mechanisms of Anti-inflammatory Actions

2009 • 73 citations

Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung

2013 • 70 citations

Spinal Actions of Lipoxin A4 and 17(R)-Resolvin D1 Attenuate Inflammation-Induced Mechanical Hypersensitivity and Spinal TNF Release

2013 • 69 citations

Omega-3 fatty acid-derived mediator, Resolvin E1, ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis in NC/Nga mice

2012 • 65 citations

Stereochemical assignment and anti-inflammatory properties of the omega-3 lipid mediator resolvin E3

2013 • 61 citations

Transcriptional regulation of the human FPR2/ALX gene: evidence of a heritable genetic variant that impairs promoter activity

2011 • 60 citations

Influenza — Time to Target the Host?

2013 • 56 citations

Maternal dietary omega-3 fatty acid intake increases resolvin and protectin levels in the rat placenta

2013 • 56 citations

Bone Marrow-Derived Dendritic Cells Generated in the Presence of Resolvin E1 Induce Apoptosis of Activated CD4+ T Cells

2008 • 56 citations

Microglial ramification and redistribution concomitant with the attenuation of choroidal neovascularization by neuroprotectin D1.

2013 • 55 citations

Aspirin-triggered lipoxin enhances macrophage phagocytosis of bacteria while inhibiting inflammatory cytokine production

2011 • 52 citations

Resolvin D1 Reduces the Immunoinflammatory Response of the Rat Eye following Uveitis

2012 • 51 citations

Tonic inhibition of chemotaxis in human plasma

2008 • 50 citations

Neuroprotectin D1 Reduces the Severity of Herpes Simplex Virus–Induced Corneal Immunopathology

2013 • 50 citations

ALX/FPR2 receptor for RvD1 is expressed and functional in salivary glands

2013 • 50 citations

Nutrigenetic Disruption of Inflammation-Resolution Homeostasis and Atherogenesis

2011 • 42 citations

Baking Reduces Prostaglandin, Resolvin, and Hydroxy-Fatty Acid Content of Farm-Raised Atlantic Salmon (Salmo salar)

2011 • 36 citations

Mechanisms of Disease: leukotrienes and lipoxins in scleroderma lung disease—insights and potential therapeutic implications

2007 • 34 citations

The effects of resolvins on dermal wound healing

2012 • 2 citations