In Vivo Phosphorylation of Insulin Receptor Substrate 1 at Serine 789 by a Novel Serine Kinase in Insulin-resistant Rodents

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1990 • 12,897 citations

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1988 • 6,107 citations

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

1996 • 2,561 citations

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Disruption of IRS-2 causes type 2 diabetes in mice

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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

1991 • 1,463 citations

The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307

2000 • 1,423 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Pathophysiology of insulin resistance in human disease

1995 • 1,239 citations

F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

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Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

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1994 • 914 citations

Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

1999 • 867 citations

Function of WW Domains as Phosphoserine- or Phosphothreonine-Binding Modules

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The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways

1993 • 629 citations

Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats

1999 • 594 citations

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1997 • 582 citations

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2001 • 577 citations

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1993 • 543 citations

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1993 • 452 citations

Tumor Necrosis Factor α-induced Phosphorylation of Insulin Receptor Substrate-1 (IRS-1)

1995 • 426 citations

Insulin and Obesity in the Zucker Genetically Obese Rat “Fatty”

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1992 • 331 citations

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1992 • 328 citations

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1997 • 316 citations

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1994 • 305 citations

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse.

1997 • 301 citations

Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation and Function by Mitogen-activated Protein Kinase

1997 • 300 citations

Binding of the Ras Activator Son of Sevenless to Insulin Receptor Substrate-1 Signaling Complexes

1993 • 298 citations

Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus

1997 • 288 citations

5′-AMP-activated Protein Kinase Phosphorylates IRS-1 on Ser-789 in Mouse C2C12 Myotubes in Response to 5-Aminoimidazole-4-carboxamide Riboside

2001 • 247 citations

Protein Kinase C Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation Requires Serine 612

1997 • 245 citations

The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin.

1994 • 234 citations

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1999 • 224 citations

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1996 • 222 citations

Role of IRS-1-GRB-2 complexes in insulin signaling.

1994 • 215 citations

Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells.

1993 • 207 citations

Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation by an Akt/Phosphatidylinositol 3-Kinase Pathway

1999 • 207 citations

Molecular Mechanism of Insulin-Induced Degradation of Insulin Receptor Substrate 1

2002 • 204 citations

Phosphorylation of Insulin Receptor Substrate-1 (IRS-1) by Protein Kinase B Positively Regulates IRS-1 Function

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Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal.

1990 • 183 citations

Altered Expression Levels and Impaired Steps in the Pathway to Phosphatidylinositol 3-Kinase Activation via Insulin Receptor Substrates 1 and 2 in Zucker Fatty Rats

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Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM

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The Fyn Tyrosine Kinase Binds Irs-1 and Forms a Distinct Signaling Complex during Insulin Stimulation

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1989 • 116 citations

Stimulation of glucose transport and glucose transporter phosphorylation by okadaic acid in rat adipocytes.

1990 • 116 citations

Identification of Enhanced Serine Kinase Activity in Insulin Resistance

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Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase

1994 • 95 citations

A manual sequencing method for identification of phosphorylated amino acids in phosphopeptides

1991 • 87 citations

Activation of protein kinase C alpha inhibits insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1.

1994 • 87 citations

Release of Insulin Receptor Substrate Proteins from an Intracellular Complex Coincides with the Development of Insulin Resistance

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Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II.

1993 • 80 citations

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1995 • 75 citations

Abnormal insulin and glucose metabolism in the JCR:LA-corpulent rat

1994 • 68 citations

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1991 • 61 citations

Glutamate Regulates Kainate-binding Protein Expression in Cultured Chick Bergmann Glia through an Activator Protein-1 Binding Site

2000 • 60 citations

Practical Protein Chemistry-A Handbook

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Comparison of the enteroinsular axis in two strains of obese rat, the fatty Zucker and the JCR:LA-corpulent.

1991 • 34 citations

The PI3-Kinase Serine Kinase Phosphorylates Its p85 Subunit and IRS-1 in PI3-Kinase/IRS-1 Complexes

1995 • 31 citations