Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

Obesity is associated with macrophage accumulation in adipose tissue

2003 • 8,349 citations

Obesity is associated with macrophage accumulation in adipose tissue

2003 • 7,795 citations

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

1993 • 7,219 citations

Obesity alters gut microbial ecology

2005 • 5,818 citations

The gut microbiota as an environmental factor that regulates fat storage

2004 • 5,730 citations

Host-Bacterial Mutualism in the Human Intestine

2005 • 4,852 citations

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

Inflammation, stress, and diabetes

2005 • 3,786 citations

TLR4 links innate immunity and fatty acid–induced insulin resistance

2006 • 3,422 citations

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

1996 • 2,561 citations

Mechanisms underlying the resistance to diet-induced obesity in germ-free mice

2007 • 2,435 citations

Endotoxin signal transduction in macrophages

1996 • 803 citations

Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis

2006 • 800 citations

Role of the Toll-like Receptor 4/NF-κB Pathway in Saturated Fatty Acid–Induced Inflammatory Changes in the Interaction Between Adipocytes and Macrophages

2006 • 775 citations

Resistance to Endotoxin Shock and Reduced Dissemination of Gram-Negative Bacteria in CD14-Deficient Mice

1996 • 760 citations

The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage.

1988 • 654 citations

Gut Bacterial Translocation via the Portal Vein

1991 • 494 citations

Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes

2006 • 452 citations

Enterocyte TLR4 Mediates Phagocytosis and Translocation of Bacteria Across the Intestinal Barrier

2006 • 409 citations

Improvement of Glucose Tolerance and Hepatic Insulin Sensitivity by Oligofructose Requires a Functional Glucagon-Like Peptide 1 Receptor

2006 • 395 citations

Oligofructose Promotes Satiety in Rats Fed a High‐Fat Diet: Involvement of Glucagon‐Like Peptide‐1

2005 • 372 citations

The CD14 Monocyte Differentiation Antigen Maps to a Region Encoding Growth Factors and Receptors

1988 • 344 citations

C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet

2007 • 342 citations

Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes?

2006 • 334 citations

The prebiotic effects of biscuits containing partially hydrolysed guar gum and fructo-oligosaccharides – a human volunteer study

2001 • 307 citations

Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage

2005 • 306 citations

Modulatory effects of sCD14 and LBP on LPS-host cell interactions

2005 • 265 citations

Analysis of 16S libraries of mouse gastrointestinal microflora reveals a large new group of mouse intestinal bacteria b bThe GenBank accession numbers for the clone sequences reported in this paper can be found in Table 1 T1 ; the accession number for isolate MIB-CB3 is AJ418059.

2002 • 246 citations

Divergent Response to LPS and Bacteria in CD14-Deficient Murine Macrophages

2000 • 227 citations

Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation

2007 • 213 citations

Lipopolysaccharide (LPS)-Binding Protein Mediates LPS Detoxification by Chylomicrons

2003 • 206 citations

Clinical laboratory differentiation of infectious versus non-infectious systemic inflammatory response syndrome

2004 • 188 citations

The Role of Bifidobacteria in Gut Barrier Function After Thermal Injury in Rats

2006 • 187 citations

In Vivo Effects of Bifidobacteria and Lactoferrin on Gut Endotoxin Concentration and Mucosal Immunity in Balb/c Mice

2004 • 178 citations

Effect of a prolonged low-dose lipopolysaccharide infusion on feed intake and metabolism in heifers.

1999 • 131 citations

Activation of Peripheral Blood CD14+ Monocytes Occurs in Diabetes

2005 • 129 citations

Roles of the Host Oxidative Immune Response and Bacterial Antioxidant Rubrerythrin during Porphyromonas gingivalis Infection

2006 • 116 citations

Lipid infusion lowers sympathetic nervous activity and leads to increased β-cell responsiveness to glucose

1999 • 113 citations

Polymyxin B reduces cecal flora, TNF production and hepatic steatosis during total parenteral nutrition in the rat

1991 • 112 citations

Involvement of cytokines in eating disorders: a critical review of the human literature

2003 • 104 citations

CD14 Monocyte Receptor, Involved in the Inflammatory Cascade, and Insulin Sensitivity

2003 • 96 citations

The CD14 monocyte differentiation antigen maps to a region encoding growth factors and receptors

1988 • 73 citations

Peroxisome Proliferator-Activated Receptor-α-Null Mice Have Increased White Adipose Tissue Glucose Utilization, GLUT4, and Fat Mass: Role in Liver and Brain

2006 • 71 citations

Effect of ischemia on intestinal permeability of lipopolysaccharides

2001 • 69 citations

Lipopolysaccharide Transport System across Colonic Epithelial Cells in Normal and Infective Rat

2004 • 66 citations

Pattern of progression in liver injury following jejunoileal bypass for morbid obesity

1987 • 59 citations

Impaired Glucose Homeostasis in Mice Lacking the α1b-Adrenergic Receptor Subtype

2004 • 51 citations

Intestinal lipoproteins in the rat with D-(+)-galactosamine hepatitis.

1983 • 29 citations

Current perspectives on behavioural and cellular mechanisms of illness anorexia

2005 • 22 citations