Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

2001 • 156,143 citations

Toll-like receptors and innate immunity

2001 • 4,138 citations

TLR4 links innate immunity and fatty acid–induced insulin resistance

2006 • 3,422 citations

Cellular mechanisms of insulin resistance

2000 • 2,692 citations

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

2001 • 1,849 citations

Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

2003 • 1,469 citations

Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

2004 • 1,436 citations

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB

2001 • 1,427 citations

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.

1990 • 1,377 citations

BIOCHEMISTRY OF ENDOTOXINS

1990 • 1,201 citations

Insulin resistance differentially affects the PI 3-kinase– and MAP kinase–mediated signaling in human muscle

2000 • 1,119 citations

A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways

2007 • 972 citations

Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance

2007 • 823 citations

Prevention of fat-induced insulin resistance by salicylate

2001 • 713 citations

Saturated Fatty Acid Activates but Polyunsaturated Fatty Acid Inhibits Toll-like Receptor 2 Dimerized with Toll-like Receptor 6 or 1

2004 • 475 citations

Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes

2006 • 452 citations

Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

2007 • 447 citations

Bacterial Lipopolysaccharide and IFN-γ Induce Toll-Like Receptor 2 and Toll-Like Receptor 4 Expression in Human Endothelial Cells: Role of NF-κB Activation

2001 • 445 citations

Synergistic interaction between exercise and insulin on peripheral glucose uptake.

1981 • 411 citations

NF-κB as a primary regulator of the stress response

1999 • 407 citations

Activation of Interleukin-6 Gene Expression through the NF-κB Transcription Factor

1990 • 379 citations

AMP-Activated Protein Kinase (AMPK) Is Activated in Muscle of Subjects With Type 2 Diabetes During Exercise

2001 • 369 citations

Toll-like Receptor-2 Is Essential for the Development of Palmitate-induced Insulin Resistance in Myotubes

2006 • 254 citations

Signaling Specificity of Interleukin-6 Action on Glucose and Lipid Metabolism in Skeletal Muscle

2006 • 235 citations

Tumor Necrosis Factor-regulated Biphasic Activation of NF-κB Is Required for Cytokine-induced Loss of Skeletal Muscle Gene Products

2003 • 235 citations

Toll-like receptors as potential therapeutic targets for multiple diseases

2002 • 229 citations

Insulin Action and Glucose Metabolism in Nondiabetic Control and NIDDM Subjects: Comparison Using Human Skeletal Muscle Cell Cultures

1995 • 220 citations

Fatty Acid-induced Insulin Resistance in L6 Myotubes Is Prevented by Inhibition of Activation and Nuclear Localization of Nuclear Factor κB

2004 • 215 citations

Antagonistic antibody prevents toll-like receptor 2–driven lethal shock-like syndromes

2004 • 204 citations

Reduced Skeletal Muscle Inhibitor of κBβ Content Is Associated With Insulin Resistance in Subjects With Type 2 Diabetes

2006 • 145 citations

Modulation of the expression of cyclooxygenase‐2 by fatty acids mediated through Toll‐like receptor 4‐derived signaling pathways¹

2001 • 134 citations

Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88-dependent signaling pathway

2002 • 127 citations

Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle

2007 • 118 citations

Nuclear factor κB-dependent mechanisms coordinate the synergistic effect of PMA and cytokines on the induction of superoxide dismutase 2

2000 • 115 citations

Respiratory epithelial cells require Toll-like receptor 4 for induction of Human β-defensin 2 by Lipopolysaccharide

2005 • 105 citations

Role of abnormal free fatty acid metabolism in the development of non-insulin-dependent diabetes mellitus

1988 • 86 citations

Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects. Comparison using human skeletal muscle cell cultures

1995 • 60 citations

Palmitate action to inhibit glycogen synthase and stimulate protein phosphatase 2A increases with risk factors for type 2 diabetes

2007 • 8 citations