Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes
Data up to Jan 2025
Total Citations Per Year
Abstract
References (48)
A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding
1976 • 225,752 citations
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
1995 • 2,106 citations
Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)
2001 • 1,789 citations
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
2001 • 1,202 citations
Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture
1974 • 1,037 citations
Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation
1994 • 1,020 citations
AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation
1999 • 997 citations
Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.
1994 • 923 citations
Protein Kinase B/Akt Participates in GLUT4 Translocation by Insulin in L6 Myoblasts
1999 • 590 citations
Signaling Mechanisms That Regulate Glucose Transport
1999 • 525 citations
The Relationship between the Insulin-binding Capacity of Fat Cells and the Cellular Response to Insulin
1971 • 464 citations
1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.
1994 • 436 citations
Molecular Basis of Insulin-stimulated GLUT4 Vesicle Trafficking
1999 • 417 citations
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase
1999 • 396 citations
Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids.
1997 • 340 citations
A Role for Protein Kinase Bβ/Akt2 in Insulin-Stimulated GLUT4 Translocation in Adipocytes
1999 • 316 citations
Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity.
1991 • 311 citations
Moving GLUT4: The Biogenesis and Trafficking of GLUT4 Storage Vesicles
1997 • 301 citations
Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus
1997 • 288 citations
Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase
1995 • 277 citations
An in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjects.
1983 • 266 citations
Molecular mechanisms for the control of translation by insulin
1997 • 257 citations
In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin-dependent diabetes mellitus.
1983 • 249 citations
Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction.
2000 • 224 citations
Stimulation of Lipolysis in Humans by Physiological Hypercortisolemia
1991 • 199 citations
Comparison of two methods for determining human adipose cell size
1972 • 188 citations
Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM
1999 • 148 citations
Abnormal Regulation of the Hypothalamo-Pituitary Adrenal Axis in the Genetically Obesefa/faRat*
1990 • 145 citations
Insulin Resistance in Cushing’s Syndrome*
1983 • 144 citations
GLUT4Gene Regulation and Manipulation
1999 • 133 citations
Radiometric assays for glycerol, glucose, and glycogen
1989 • 121 citations
Compartmentalization of protein traffic in insulin-sensitive cells
1996 • 108 citations
Glucose turnover and adipose tissue lipolysis are insulin-resistant in healthy relatives of type 2 diabetes patients: is cellular insulin resistance a secondary phenomenon?
1999 • 102 citations
Dexamethasone down-regulation of insulin receptor substrate-1 in 3T3-L1 adipocytes.
1994 • 86 citations
Cellular mechanisms in selected states of insulin resistance: Human obesity, glucocorticoid excess, and chronic renal failure
1985 • 84 citations
Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: comparison with fat cells.
1995 • 81 citations
Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with Type II diabetes mellitus
1999 • 73 citations
PKB Inhibition Prevents the Stimulatory Effect of Insulin on Glucose Transport and Protein Translocation but Not the Antilipolytic Effect in Rat Adipocytes
2000 • 63 citations
Impaired phosphorylation and insulin-stimulated translocation to the plasma membrane of protein kinase B/Akt in adipocytes from Type II diabetic subjects
2000 • 62 citations
Dexamethasone Regulates the Glucose Transport System in Primary Cultured Adipocytes: Different Mechanisms of Insulin Resistance After Acute and Chronic Exposure*
1989 • 62 citations
Regulation of insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and dexamethasone.
1994 • 61 citations
Effects of prednisolone and dexamethasone in vivo and in vitro: Studies of insulin binding, deoxyglucose uptake and glucose oxidation in rat adipocytes
1981 • 47 citations
Regulation of glucose transporters in cultured rat adipocytes: synergistic effect of insulin and dexamethasone on GLUT4 gene expression through promoter activation.
1995 • 47 citations
Possible role for the glucose-fatty acid cycle in dexamethasone-induced insulin antagonism in rats
1987 • 45 citations
Peroxovanadate and insulin action in adipocytes from NIDDM patients. Evidence against a primary defect in tyrosine phosphorylation
1997 • 41 citations
Insulin can enhance GLUT4 gene expression in 3T3-F442A cells and this effect is mimicked by vanadate but counteracted by cAMP and high glucose – potential implications for insulin resistance
2001 • 33 citations
Insulin Can Rapidly Increase Cell Surface Insulin Binding Capacity in Rat Adipocytes: A Novel Mechanism Related to Insulin Sensitivity
1992 • 17 citations
Inhibition of hexose transport in adipocytes by dexamethasone: role of protein synthesis
1985 • 14 citations