Role of the PD-1 Pathway in the Immune Response

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

2016 • 29,943 citations

Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review

2017 • 14,809 citations

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

PD-1 and Its Ligands in Tolerance and Immunity

2008 • 4,838 citations

Regulatory T Cells and Immune Tolerance

2008 • 4,778 citations

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

2017 • 4,003 citations

T cell exhaustion

2011 • 3,396 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

1992 • 2,906 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates

2010 • 2,721 citations

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

2007 • 2,575 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

The PD‐1 pathway in tolerance and autoimmunity

2010 • 2,064 citations

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

2009 • 1,887 citations

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 • 1,761 citations

CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms

2005 • 1,746 citations

Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses

2007 • 1,603 citations

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

1996 • 1,473 citations

Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

2007 • 1,375 citations

Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity

2012 • 1,274 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

CTLA-4–Ig regulates tryptophan catabolism in vivo

2002 • 1,150 citations

Tissue expression of PD-L1 mediates peripheral T cell tolerance

2006 • 1,145 citations

SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation

2004 • 1,128 citations

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

2005 • 955 citations

Redefining Chronic Viral Infection

2009 • 941 citations

Blockade of Programmed Death-1 Ligands on Dendritic Cells Enhances T Cell Activation and Cytokine Production

2003 • 933 citations

Expression of Programmed Death 1 Ligands by Murine T Cells and APC

2002 • 908 citations

B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

2001 • 850 citations

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

2008 • 814 citations

All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation

2007 • 813 citations

Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero

2008 • 803 citations

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

2001 • 786 citations

The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

2003 • 766 citations

Enhancing SIV-specific immunity in vivo by PD-1 blockade

2008 • 731 citations

In Vivo Instruction of Suppressor Commitment in Naive T Cells

2004 • 726 citations

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

2008 • 710 citations

TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling

2004 • 706 citations

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

2009 • 694 citations

PD-1:PD-L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL-2

2002 • 646 citations

Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation

2007 • 646 citations

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

2010 • 641 citations

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells

2004 • 609 citations

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

2003 • 594 citations

Follicular B helper T cells in antibody responses and autoimmunity

2005 • 592 citations

PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells

2003 • 584 citations

Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4

2005 • 532 citations

Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells

2007 • 502 citations

Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes

2007 • 502 citations

Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis

2003 • 486 citations

The Common γ-Chain Cytokines IL-2, IL-7, IL-15, and IL-21 Induce the Expression of Programmed Death-1 and Its Ligands

2008 • 485 citations

Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

2010 • 446 citations

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8⁺ T cell activation and cytolysis

2003 • 436 citations

The Inhibitory Receptor PD-1 Regulates IgA Selection and Bacterial Composition in the Gut

2012 • 411 citations

Establishment of NOD-Pdcd1^-/-mice as an efficient animal model of type I diabetes

2005 • 409 citations

The PDL1-PD1 Axis Converts Human T _H 1 Cells into Regulatory T Cells

2011 • 406 citations

A critical role for the programmed death ligand 1 in fetomaternal tolerance

2005 • 402 citations

Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade

2006 • 396 citations

B7-H1 Determines Accumulation and Deletion of Intrahepatic CD8+ T Lymphocytes

2004 • 375 citations

Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3 ⁺ CD4 ⁺ regulatory T cells

2008 • 370 citations

NFATc1 Regulates PD-1 Expression upon T Cell Activation

2008 • 362 citations

Selective Survival of Naturally Occurring Human CD4+CD25+Foxp3+ Regulatory T Cells Cultured with Rapamycin

2007 • 335 citations

Follicular Helper T Cell Differentiation Requires Continuous Antigen Presentation that Is Independent of Unique B Cell Signaling

2010 • 322 citations

Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease

2004 • 322 citations

Blockade of Programmed Death-1 Engagement Accelerates Graft-Versus-Host Disease Lethality by an IFN-γ-Dependent Mechanism

2003 • 315 citations

B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance

2010 • 311 citations

Insulin-induced remission in new-onset NOD mice is maintained by the PD-1–PD-L1 pathway

2006 • 303 citations

TGFβ signalling in control of T-cell-mediated self-reactivity

2007 • 294 citations

PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV

2009 • 288 citations

Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 Interaction

2003 • 285 citations

B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells

2011 • 271 citations

Interferon-β enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis

2004 • 269 citations

Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia

2010 • 267 citations

B7-H1 (Programmed Death-1 Ligand) on Dendritic Cells Is Involved in the Induction and Maintenance of T Cell Anergy

2003 • 263 citations

Expression and Regulation of the PD-L1 Immunoinhibitory Molecule on Microvascular Endothelial Cells

2002 • 256 citations

Endothelial Programmed Death-1 Ligand 1 (PD-L1) Regulates CD8 ⁺ T-Cell–Mediated Injury in the Heart

2007 • 244 citations

PD-1 Protects against Inflammation and Myocyte Damage in T Cell-Mediated Myocarditis

2012 • 243 citations

PD-1 Regulates Self-Reactive CD8+ T Cell Responses to Antigen in Lymph Nodes and Tissues

2007 • 237 citations

Programmed Death-1 Targeting Can Promote Allograft Survival

2002 • 236 citations

Phenotype, Function, and Gene Expression Profiles of Programmed Death-1hi CD8 T Cells in Healthy Human Adults

2011 • 231 citations

T-cell tolerance or function is determined by combinatorial costimulatory signals

2006 • 229 citations

Maternal Acceptance of the Fetus: True Human Tolerance

2007 • 227 citations

Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells

2009 • 215 citations

Cutting Edge: OX40 Inhibits TGF-β- and Antigen-Driven Conversion of Naive CD4 T Cells into CD25+Foxp3+ T cells

2007 • 202 citations

PDL1 Is Required for Peripheral Transplantation Tolerance and Protection from Chronic Allograft Rejection

2007 • 195 citations

PD-1 on dendritic cells impedes innate immunity against bacterial infection

2009 • 195 citations

Costimulatory pathways in transplantation: challenges and new developments

2009 • 192 citations

Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient Mice

2000 • 181 citations

Contribution of the PD‐1 ligands/PD‐1 signaling pathway to dendritic cell‐mediated CD4⁺ T cell activation

2006 • 179 citations

Role of the Programmed Death-1 Pathway in Regulation of Alloimmune Responses In Vivo

2005 • 177 citations

Programmed Death Ligand 1 Regulates a Critical Checkpoint for Autoimmune Myocarditis and Pneumonitis in MRL Mice

2008 • 177 citations

PD‐L2 expression extends beyond dendritic cells/macrophages to B1 cells enriched for V_H11/V_H12 and phosphatidylcholine binding

2007 • 174 citations

Regulation of T cell activation and tolerance by PDL2

2006 • 159 citations

The Link between the PDL1 Costimulatory Pathway and Th17 in Fetomaternal Tolerance

2011 • 156 citations

Stimulating PD-1???negative signals concurrent with blocking CD154 co-stimulation induces long-term islet allograft survival1

2003 • 151 citations

Analysis of the Role of Negative T Cell Costimulatory Pathways in CD4 and CD8 T Cell-Mediated Alloimmune Responses In Vivo

2005 • 149 citations

Cutting Edge: Murine Vascular Endothelium Activates and Induces the Generation of Allogeneic CD4+25+Foxp3+ Regulatory T Cells

2005 • 148 citations

Programmed Death-1 (PD-1):PD-Ligand 1 Interactions Inhibit TCR-Mediated Positive Selection of Thymocytes

2005 • 138 citations

CD4 ⁺ CD25 ⁺ Regulatory Cells from Human Peripheral Blood Express Very High Levels of CD25 Ex Vivo

2003 • 138 citations

Blockade of B7-H1 (Programmed Death Ligand 1) Enhances Humoral Immunity by Positively Regulating the Generation of T Follicular Helper Cells

2011 • 126 citations

The Novel Costimulatory Programmed Death Ligand 1/B7.1 Pathway Is Functional in Inhibiting Alloimmune Responses In Vivo

2011 • 125 citations

Plasmacytoid Dendritic Cell Precursors Induce Allogeneic T‐Cell Hyporesponsiveness and Prolong Heart Graft Survival

2005 • 124 citations

The effect of immunosuppressive drug rapamycin on regulatory CD4+CD25+Foxp3+T cells in mice

2007 • 112 citations

TGF-β1 modulates Foxp3 expression and regulatory activity in distinct CD4+ T cell subsets

2007 • 111 citations

Absence of Programmed Death Receptor 1 Alters Thymic Development and Enhances Generation of CD4/CD8 Double-Negative TCR-Transgenic T Cells

2003 • 110 citations

PD-L2 is expressed on activated human T cells and regulates their function

2011 • 108 citations

PD‐1/B7‐H1 Interaction Contribute to the Spontaneous Acceptance of Mouse Liver Allograft

2009 • 107 citations

Critical Role of Donor Tissue Expression of Programmed Death Ligand-1 in Regulating Cardiac Allograft Rejection and Vasculopathy

2008 • 89 citations

Renal tubular PD-L1 (CD274) suppresses alloreactive human T-cell responses

2010 • 78 citations

Programmed cell death 1 (PD-1) and its ligand PD-L1 are required for allograft tolerance

2007 • 75 citations

Th17: Contributors to Allograft Rejection and a Barrier to the Induction of Transplantation Tolerance?

2011 • 69 citations

Essential Role of PDL1 Expression on Nonhematopoietic Donor Cells in Acquired Tolerance to Vascularized Cardiac Allografts

2011 • 62 citations

Programmed death-1 (PD-1) defines a transient and dysfunctional oligoclonal T cell population in acute homeostatic proliferation

2007 • 61 citations

Programmed death-1 is required for systemic self-tolerance in newly generated T cells during the establishment of immune homeostasis

2011 • 54 citations

PD-1-Dependent Mechanisms Maintain Peripheral Tolerance of Donor-Reactive CD8+ T Cells to Transplanted Tissue

2008 • 48 citations

Host APCs Augment In Vivo Expansion of Donor Natural Regulatory T Cells via B7H1/B7.1 in Allogeneic Recipients

2011 • 47 citations

Gene Transfer of Programmed Death Ligand-1.Ig Prolongs Cardiac Allograft Survival

2006 • 43 citations

A Novel Alloantigen-Specific CD8+PD1+ Regulatory T Cell Induced by ICOS-B7h Blockade In Vivo

2007 • 42 citations

Down‐modulation of programmed death 1 alters regulatory T cells and promotes experimental autoimmune encephalomyelitis

2009 • 42 citations

PD-L1/PD-1 Signal Deficiency Promotes Allogeneic Immune Responses and Accelerates Heart Allograft Rejection

2008 • 32 citations

A phase I study to evaluate safety and antitumor activity of biweekly BMS-936558 (Anti-PD-1, MDX-1106/ONO-4538) in patients with RCC and other advanced refractory malignancies.

2011 • 29 citations

Memory T cells and their exhaustive differentiation in allograft tolerance and rejection

2011 • 22 citations

Dendritic cells transfected with PD-L1 recombinant adenovirus induces T cell suppression and long-term acceptance of allograft transplantation

2011 • 12 citations