The Novel Costimulatory Programmed Death Ligand 1/B7.1 Pathway Is Functional in Inhibiting Alloimmune Responses In Vivo

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

PD-1 and Its Ligands in Tolerance and Immunity

2008 • 4,838 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

2009 • 1,887 citations

Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses

2007 • 1,603 citations

Tissue expression of PD-L1 mediates peripheral T cell tolerance

2006 • 1,145 citations

Control of peripheral T‐cell tolerance and autoimmunity via the CTLA‐4 and PD‐1 pathways

2008 • 951 citations

Blockade of Programmed Death-1 Ligands on Dendritic Cells Enhances T Cell Activation and Cytokine Production

2003 • 933 citations

Expression of Programmed Death 1 Ligands by Murine T Cells and APC

2002 • 908 citations

B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

2001 • 850 citations

PRIMARILY VASCULARIZED ALLOGRAFTS OF HEARTS IN MICE

1973 • 801 citations

The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

2003 • 766 citations

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells

2004 • 609 citations

B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance

2010 • 311 citations

A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy

2008 • 294 citations

PD-1 Regulates Self-Reactive CD8+ T Cell Responses to Antigen in Lymph Nodes and Tissues

2007 • 237 citations

Estrogen-mediated immunomodulation involves reduced activation of effector T cells, potentiation of treg cells, and enhanced expression of the PD-1 costimulatory pathway

2006 • 225 citations

PDL1 Is Required for Peripheral Transplantation Tolerance and Protection from Chronic Allograft Rejection

2007 • 195 citations

Role of the Programmed Death-1 Pathway in Regulation of Alloimmune Responses In Vivo

2005 • 177 citations

Cooperative B7-1/2 (CD80/CD86) and B7-DC Costimulation of CD4+ T Cells Independent of the PD-1 Receptor

2003 • 157 citations

Stimulating PD-1???negative signals concurrent with blocking CD154 co-stimulation induces long-term islet allograft survival1

2003 • 151 citations

Cutting Edge: Murine Vascular Endothelium Activates and Induces the Generation of Allogeneic CD4+25+Foxp3+ Regulatory T Cells

2005 • 148 citations

B7DC/PDL2 Promotes Tumor Immunity by a PD-1–independent Mechanism

2003 • 141 citations

CD4 ⁺ CD25 ⁺ Regulatory Cells from Human Peripheral Blood Express Very High Levels of CD25 Ex Vivo

2003 • 138 citations

Preferential contribution of B7‐H1 to programmed death‐1‐mediated regulation of hapten‐specific allergic inflammatory responses

2003 • 121 citations

Critical Role of Donor Tissue Expression of Programmed Death Ligand-1 in Regulating Cardiac Allograft Rejection and Vasculopathy

2008 • 89 citations

Immunoregulatory role of B7-H1 in chronicity of inflammatory responses.

2006 • 76 citations

Host APCs Augment In Vivo Expansion of Donor Natural Regulatory T Cells via B7H1/B7.1 in Allogeneic Recipients

2011 • 47 citations

Transplantation tolerance: The concept and its applicability

1999 • 44 citations

Down‐modulation of programmed death 1 alters regulatory T cells and promotes experimental autoimmune encephalomyelitis

2009 • 42 citations