Programmed Death-1 Targeting Can Promote Allograft Survival

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

The TNF and TNF Receptor Superfamilies

2001 • 3,533 citations

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

1992 • 2,906 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 • 1,761 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

1998 • 1,546 citations

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

1996 • 1,473 citations

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

1999 • 1,418 citations

B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

2001 • 850 citations

T-cell co-stimulation through B7RP-1 and ICOS

1999 • 758 citations

IMMUNE REGULATION BY CD40 AND ITS LIGAND GP39

1996 • 653 citations

PD-1:PD-L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL-2

2002 • 646 citations

Requirement of the Chemokine Receptor CXCR3 for Acute Allograft Rejection

2000 • 619 citations

The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses

2000 • 507 citations

Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses

1998 • 469 citations

PD-1: an inhibitory immunoreceptor involved in peripheral tolerance

2001 • 467 citations

Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes

1998 • 466 citations

B7h, a Novel Costimulatory Homolog of B7.1 and B7.2, Is Induced by TNFα

1999 • 440 citations

Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection

1996 • 416 citations

The expanding B7 superfamily: Increasing complexity in costimulatory signals regulating T cell function

2001 • 413 citations

Donor-Derived Ip-10 Initiates Development of Acute Allograft Rejection

2001 • 381 citations

Functional Responses and Costimulator Dependence of Memory CD4+ T Cells

2000 • 318 citations

Importance of ICOS–B7RP-1 costimulation in acute and chronic allograft rejection

2001 • 317 citations

Immunoreceptor tyrosine-based inhibition motifs

1997 • 279 citations

ICOS is critical for T helper cell–mediated lung mucosal inflammatory responses

2001 • 273 citations

Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection

2000 • 255 citations

Developmentally regulated expression of the PD-1 protein on the surface of double-negative(CD4^–CD8^–) thymocytes

1996 • 243 citations

Structure and Chromosomal Localization of the Human PD-1 Gene (PDCD1)

1994 • 234 citations

Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent

2000 • 207 citations

Chemokines and their receptors in allograft rejection

2000 • 177 citations

BENEFICIAL EFFECTS OF TARGETING CCR5 IN ALLOGRAFT RECIPIENTS1

2001 • 164 citations

Host CD40 Ligand Deficiency Induces Long-Term Allograft Survival and Donor-Specific Tolerance in Mouse Cardiac Transplantation But Does Not Prevent Graft Arteriosclerosis

2000 • 154 citations

CD8+ T CELLS CONTRIBUTE TO THE DEVELOPMENT OF TRANSPLANT ARTERIOSCLEROSIS DESPITE CD154 BLOCKADE1

2000 • 77 citations

Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists.

1996 • 77 citations

Immunoreceptor Tyrosine-Based Inhibitory Motifs on Activating Molecules

2000 • 46 citations