CTLA-4–Ig regulates tryptophan catabolism in vivo

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

1998 • 2,538 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism

1999 • 1,560 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation

2001 • 1,032 citations

Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism

1991 • 1,018 citations

T cell apoptosis by tryptophan catabolism

2002 • 960 citations

"Infectious" Transplantation Tolerance

1993 • 890 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

p38-dependent marking of inflammatory genes for increased NF-κB recruitment

2001 • 692 citations

Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?

1999 • 650 citations

The Emerging Role of CTLA-4 as an Immune Attenuator

1997 • 637 citations

T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.

1992 • 558 citations

Functions of CD40 on B cells, dendritic cells and other cells

1997 • 490 citations

Interaction of NF-κB and NFAT with the Interferon-γ Promoter

1997 • 427 citations

Prevention of T cell–driven complement activation and inflammation by tryptophan catabolism during pregnancy

2001 • 425 citations

CTLA-4 Regulates Induction of Anergy In Vivo

2001 • 409 citations

CTLA-4: a negative regulator of autoimmune disease.

1996 • 382 citations

Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes

1998 • 295 citations

IL-12 Acts Directly on DC to Promote Nuclear Localization of NF-κB and Primes DC for IL-12 Production

1998 • 274 citations

Functional expression of indoleamine 2,3-dioxygenase by murine CD8α+ dendritic cells

2002 • 251 citations

Bidirectional Negative Regulation of Human T and Dendritic Cells by CD47 and Its Cognate Receptor Signal-Regulator Protein-α: Down-Regulation of IL-12 Responsiveness and Inhibition of Dendritic Cell Activation

2001 • 232 citations

Distinct Role of CD80 and CD86 in the Regulation of the Activation of B Cell and B Cell Lymphoma

2002 • 231 citations

Studies in B7-Deficient Mice Reveal a Critical Role for B7 Costimulation in Both Induction and Effector Phases of Experimental Autoimmune Encephalomyelitis

1999 • 219 citations

Maximal Proliferation of Cytotoxic T Lymphocytes Requires Reverse Signaling through Fas Ligand

1998 • 217 citations

CTLA-4 and T cell activation

1999 • 209 citations

The Role of CD80, CD86, and CTLA4 in Alloimmune Responses and the Induction of Long-Term Allograft Survival

1999 • 208 citations

IL-6 Inhibits the Tolerogenic Function of CD8α+ Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

2001 • 185 citations

Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28

1998 • 185 citations

B7-1 Engagement of Cytotoxic T Lymphocyte Antigen 4 Inhibits T Cell Activation in the Absence of CD28

1998 • 179 citations

Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. Mediation of specific suppression by T helper/inducer cells.

1985 • 163 citations

Ephrins in reverse, park and drive

2002 • 162 citations

TRANSCRIPTIONAL ACTIVATION OF INDOLEAMINE DIOXYGENASE BY INTERLEUKIN 1 AND TUMOR NECROSIS FACTOR α IN INTERFERON-TREATED EPITHELIAL CELLS

2000 • 162 citations

CD40 Ligation Ablates the Tolerogenic Potential of Lymphoid Dendritic Cells

2001 • 141 citations

Differential regulation of human indoleamine 2,3-dioxygenase gene expression by interferons-gamma and -alpha. Analysis of the regulatory region of the gene and identification of an interferon-gamma-inducible DNA-binding factor.

1993 • 137 citations

Designer dendritic cells for tolerance induction: guided not misguided missiles

2001 • 132 citations

Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization.

1996 • 128 citations

Immature and Mature CD8α+ Dendritic Cells Prolong the Survival of Vascularized Heart Allografts

2002 • 122 citations

The p38 Mitogen-Activated Protein Kinase Is Required for IL-12-Induced IFN-γ Expression

2000 • 118 citations

CTLA-4 up-regulation plays a role in tolerance mediated by CD45

2001 • 113 citations

Cutting Edge: Differentiation of Antitumor CTL In Vivo Requires Host Expression of Stat1

1999 • 103 citations

IFN-γ Inhibits Presentation of a Tumor/Self Peptide by CD8α− Dendritic Cells Via Potentiation of the CD8α+ Subset

2000 • 101 citations

Distinct mechanisms for the induction and maintenance of allograft tolerance with CTLA4-Fc treatment.

1997 • 98 citations

Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Engagement Delivers an Inhibitory Signal through the Membrane-Proximal Region in the Absence of the Tyrosine Motif in the Cytoplasmic Tail

1999 • 96 citations

Putting the brakes on innate immunity: a regulatory role for CD200?

2001 • 78 citations

Expression of B7 Molecules in Recipient, Not Donor, Mice Determines the Survival of Cardiac Allografts

1999 • 67 citations

The role of donor and recipient B7-1 (CD80) in allograft rejection.

1997 • 60 citations

Human Anergic CD4+ T Cells Can Act as Suppressor Cells by Affecting Autologous Dendritic Cell Conditioning and Survival

2002 • 46 citations

COSTIMULATION BLOCKADE PROMOTES THE APOPTOTIC DEATH OF GRAFT-INFILTRATING T CELLS AND PROLONGS SURVIVAL OF HEPATIC ALLOGRAFTS FROM FLT3L-TREATED DONORS1

2001 • 42 citations

The Immunosuppressive Activity of Proinflammatory Cytokines in Experimental Models Potential for Therapeutic Intervention in Autoimmunity

2002 • 18 citations