Blockade of Programmed Death-1 Ligands on Dendritic Cells Enhances T Cell Activation and Cytokine Production

Dendritic cells and the control of immunity

1998 • 14,345 citations

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

1992 • 2,906 citations

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

2002 • 2,879 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

Antigen Presentation and T Cell Stimulation by Dendritic Cells

2002 • 1,860 citations

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 • 1,761 citations

The B7–CD28 superfamily

2002 • 1,646 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

1996 • 1,473 citations

Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells

2001 • 1,384 citations

Induction of tolerance by IL-10-treated dendritic cells.

1997 • 1,263 citations

CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy

2001 • 964 citations

B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

2001 • 850 citations

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

2001 • 786 citations

PD-1:PD-L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL-2

2002 • 646 citations

The Interaction Properties of Costimulatory Molecules Revisited

2002 • 640 citations

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4

1995 • 577 citations

Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application

1999 • 499 citations

Cytotoxic T Lymphocyte Antigen-4 Accumulation in the Immunological Synapse Is Regulated by TCR Signal Strength

2002 • 497 citations

Dendritic cells as a tool to induce anergic and regulatory T cells

2001 • 478 citations

PD-1: an inhibitory immunoreceptor involved in peripheral tolerance

2001 • 467 citations

CD4+ and CD8+ anergic T cells induced by interleukin-10–treated human dendritic cells display antigen-specific suppressor activity

2002 • 455 citations

Regulation of Antigen-Specific CD8 ⁺ T Cell Homeostasis by Perforin and Interferon-γ

2000 • 452 citations

The expanding B7 superfamily: Increasing complexity in costimulatory signals regulating T cell function

2001 • 413 citations

Expression and Regulation of the PD-L1 Immunoinhibitory Molecule on Microvascular Endothelial Cells

2002 • 256 citations

Developmentally regulated expression of the PD-1 protein on the surface of double-negative(CD4^–CD8^–) thymocytes

1996 • 243 citations

Structure and Chromosomal Localization of the Human PD-1 Gene (PDCD1)

1994 • 234 citations

B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function

2001 • 220 citations

Interleukin 10 inhibits T cell alloreaction induced by human dendritic cells

1994 • 205 citations

Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient Mice

2000 • 181 citations

IL-10 Converts Human Dendritic Cells into Macrophage-Like Cells with Increased Antibacterial Activity Against VirulentMycobacterium tuberculosis

2000 • 149 citations

Activation-Induced Expression of Human Programmed Death-1 Gene in T-Lymphocytes

1997 • 144 citations

Inhibition of human allergic T-cell responses by IL-10–treated dendritic cells: Differences from hydrocortisone-treated dendritic cells

2001 • 112 citations

Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4⁺T cells

2000 • 68 citations

Functional Effects of TNF and Lymphotoxin α1β2 on FDC-like Cells

2000 • 50 citations

Usefulness of a new CD5 antibody for the diagnosis of T-cell and B-cell lymphoproliferative disorders in paraffin sections.

1997 • 45 citations

Laser capture microdissection-based expression profiling identifies PD1-ligand as a target of the nude locus gene product

2001 • 42 citations

The Leukocyte Semaphorin CD100 Is Expressed in Most T-Cell, but Few B-Cell, Non-Hodgkin's Lymphomas

1998 • 35 citations