Regulation of T cell activation and tolerance by PDL2

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

2016 • 29,943 citations

Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review

2017 • 14,809 citations

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

Tolerogenic Dendritic Cells

2003 • 3,131 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

THE B7 FAMILY REVISITED

2005 • 2,239 citations

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 • 1,761 citations

The B7–CD28 superfamily

2002 • 1,646 citations

T Cell Anergy

2003 • 1,418 citations

Anatomical basis of tolerance and immunity to intestinal antigens

2003 • 1,365 citations

Tissue expression of PD-L1 mediates peripheral T cell tolerance

2006 • 1,145 citations

Expression of Programmed Death 1 Ligands by Murine T Cells and APC

2002 • 908 citations

B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

2001 • 850 citations

The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

2003 • 766 citations

B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity

2003 • 665 citations

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells

2004 • 609 citations

Cutting Edge: Intravenous Soluble Antigen Is Presented to CD4 T Cells by CD8− Dendritic Cells, but Cross-Presented to CD8 T Cells by CD8+ Dendritic Cells

2001 • 584 citations

Oral tolerance

2005 • 573 citations

The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses

2003 • 516 citations

Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis

2003 • 486 citations

Establishment of NOD-Pdcd1^-/-mice as an efficient animal model of type I diabetes

2005 • 409 citations

B7S1, a Novel B7 Family Member that Negatively Regulates T Cell Activation

2003 • 407 citations

B7x: A widely expressed B7 family member that inhibits T cell activation

2003 • 380 citations

Murine B7-H3 Is a Negative Regulator of T Cells

2004 • 332 citations

Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 Interaction

2003 • 285 citations

T-cell tolerance or function is determined by combinatorial costimulatory signals

2006 • 229 citations

Mesenteric lymph nodes are critical for the induction of high-dose oral tolerance in the absence of Peyer's patches

2002 • 181 citations

In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses

2005 • 152 citations

Transcriptional Regulation of Th2 Differentiation by Inducible Costimulator

2003 • 149 citations

B7DC/PDL2 Promotes Tumor Immunity by a PD-1–independent Mechanism

2003 • 141 citations

B7-DC Regulates Asthmatic Response by an IFN-γ-Dependent Mechanism

2004 • 135 citations

Differential Role of Programmed Death-Ligand 1 and Programmed Death-Ligand 2 in Regulating the Susceptibility and Chronic Progression of Experimental Autoimmune Encephalomyelitis

2006 • 115 citations

B7h is required for T cell activation, differentiation, and effector function

2003 • 109 citations

Cross-linking the B7 Family Molecule B7-DC Directly Activates Immune Functions of Dendritic Cells

2002 • 104 citations

PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis

2005 • 82 citations

The ICOS Molecule Plays a Crucial Role in the Development of Mucosal Tolerance

2005 • 75 citations

Immunity induced after a feed of antigen during early life: oral tolerancev. sensitisation

2001 • 72 citations

PD-1 ligands, negative regulators for activation of naïve, memory, and recently activated human CD4+ T cells

2004 • 71 citations

Naturally Occurring Human IgM Antibody That Binds B7-DC and Potentiates T Cell Stimulation by Dendritic Cells

2003 • 69 citations

Immunotherapeutic Potential of B7-DC (PD-L2) Cross-Linking Antibody In Conferring Antitumor Immunity

2004 • 60 citations

CD8α–11b+ dendritic cells but not CD8α+ dendritic cells mediate cross-tolerance toward intestinal antigens

2005 • 54 citations