The Inhibitory Receptor PD-1 Regulates IgA Selection and Bacterial Composition in the Gut

Obesity alters gut microbial ecology

2005 • 5,818 citations

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 • 3,323 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression

2008 • 2,099 citations

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 • 1,761 citations

Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter

2010 • 1,092 citations

A Primitive T Cell-Independent Mechanism of Intestinal Mucosal IgA Responses to Commensal Bacteria

2000 • 1,085 citations

Intraclonal generation of antibody mutants in germinal centres

1991 • 1,083 citations

IMGT(R), the international ImMunoGeneTics information system(R)

2008 • 1,067 citations

Imaging of Germinal Center Selection Events During Affinity Maturation

2006 • 760 citations

The PD-1–PD-L pathway in immunological tolerance

2006 • 681 citations

Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation

2007 • 646 citations

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

2010 • 641 citations

Follicular B helper T cells in antibody responses and autoimmunity

2005 • 592 citations

Accurate taxonomy assignments from 16S rRNA sequences produced by highly parallel pyrosequencers

2008 • 581 citations

Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora

2002 • 580 citations

Preferential Generation of Follicular B Helper T Cells from Foxp3 ⁺ T Cells in Gut Peyer's Patches

2009 • 559 citations

Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism

2009 • 485 citations

Adaptive Immune Regulation in the Gut: T Cell–Dependent and T Cell–Independent IgA Synthesis

2010 • 467 citations

In situ class switching and differentiation to IgA-producing cells in the gut lamina propria

2001 • 428 citations

Requirement for Lymphoid Tissue-Inducer Cells in Isolated Follicle Formation and T Cell-Independent Immunoglobulin A Generation in the Gut

2008 • 418 citations

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.

1995 • 393 citations

A dynamic T cell–limited checkpoint regulates affinity-dependent B cell entry into the germinal center

2011 • 390 citations

Analysis of Interleukin-21-Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription Factors

2009 • 337 citations

PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice

2011 • 290 citations

Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense

2011 • 241 citations

The majority of intestinal IgA+ and IgG+ plasmablasts in the human gut are antigen-specific

2011 • 237 citations

In vivo IgA coating of anaerobic bacteria in human faeces.

1996 • 219 citations

Universal PCR amplification of mouse immunoglobulin gene variable regions: the design of degenerate primers and an assessment of the effect of DNA polymerase 3′ to 5′ exonuclease activity

2000 • 214 citations

Th2 Lymphoproliferative Disorder of Lat Y136F Mutant Mice Unfolds Independently of TCR-MHC Engagement and Is Insensitive to the Action of Foxp3+ Regulatory T Cells

2008 • 166 citations

Steady-state generation of mucosal IgA+ plasmablasts is not abrogated by B-cell depletion therapy with rituximab

2010 • 111 citations

Improved methods for detecting selection by mutation analysis of Ig V region sequences

2008 • 85 citations

Evidence for Local Expansion of IgA Plasma Cell Precursors in Human Ileum

2009 • 36 citations