Antisense RNA: Function and Fate of Duplex RNA in Cells of Higher Eukaryotes

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1993 • 12,238 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

1993 • 4,021 citations

Conserved Structures and Diversity of Functions of RNA-Binding Proteins

1994 • 1,873 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

The “initiator” as a transcription control element

1989 • 1,597 citations

RNA editing in brain controls a determinant of ion flow in glutamate-gated channels

1991 • 1,465 citations

Mechanical Devices of the Spliceosome: Motors, Clocks, Springs, and Things

1998 • 1,121 citations

Identification of two distinct regulatory regions adjacent to the human β-interferon gene

1983 • 1,076 citations

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1990 • 1,003 citations

Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome

1995 • 994 citations

Regulation of serotonin-2C receptor G-protein coupling by RNA editing

1997 • 985 citations

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

1988 • 984 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus

1991 • 904 citations

Biochemistry of Interferons and Their Actions

1982 • 868 citations

A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells

1986 • 834 citations

pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells.

1978 • 787 citations

Control of Kinetic Properties of AMPA Receptor Channels by Nuclear RNA Editing

1994 • 735 citations

An unwinding activity that covalently modifies its double-stranded RNA substrate

1988 • 702 citations

THE STRUCTURE AND FUNCTION OF PROTEINS INVOLVED IN MAMMALIAN PRE-mRNA SPLICING

1996 • 687 citations

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

1992 • 661 citations

RNA editing of AMPA receptor subunit GluR-B: A base-paired intron-exon structure determines position and efficiency

1993 • 657 citations

Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

1993 • 638 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 617 citations

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal

1993 • 602 citations

Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities

1991 • 600 citations

Mechanism and regulation of eukaryotic protein synthesis

1992 • 591 citations

Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex.

1982 • 580 citations

Imprinted expression of the Igf2r gene depends on an intronic CpG island

1997 • 578 citations

Two small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus.

1981 • 577 citations

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

1994 • 569 citations

A conserved double-stranded RNA-binding domain.

1992 • 540 citations

Expression and Regulation by Interferon of a Double-Stranded-RNA-Specific Adenosine Deaminase from Human Cells: Evidence for Two Forms of the Deaminase

1995 • 534 citations

Mutations that lead to reiterations in the cell lineages of C. elegans

1981 • 530 citations

The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.

1992 • 530 citations

A mammalian RNA editing enzyme

1996 • 512 citations

The involvement of NF-κB in β-interferon gene regulation reveals its role as widely inducible mediator of signal transduction

1989 • 494 citations

La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate

1993 • 485 citations

The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase.

1992 • 469 citations

Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements

1993 • 440 citations

A developmentally regulated activity that unwinds RNA duplexes

1987 • 439 citations

Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing.

1994 • 435 citations

Biased hypermutation and other genetic changes in defective measles viruses in human brain infections

1988 • 431 citations

Initiation of protein synthesis by internal entry of ribosomes into the 5' nontranslated region of encephalomyocarditis virus RNA in vivo

1989 • 417 citations

The human β-interferon gene enhancer is under negative control

1986 • 395 citations

Binding of the Influenza Virus NS1 Protein to Double-Stranded RNA Inhibits the Activation of the Protein Kinase That Phosphorylates the eIF-2 Translation Initiation Factor

1995 • 391 citations

Characterization of a Human TAR RNA-Binding Protein That Activates the HIV-1 LTR

1991 • 391 citations

Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility

1995 • 390 citations

Adenovirus virus-associated RNA and translation control

1991 • 387 citations

The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans.

1993 • 383 citations

Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1

1989 • 368 citations

Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2α kinase

1986 • 358 citations

PROTEOLYTIC PROCESSING OF PICORNAVIRAL POLYPROTEIN

1990 • 357 citations

Interferon Action: RNA Cleavage Pattern of a (2′-5′)Oligoadenylate—Dependent Endonuclease

1981 • 357 citations

RNA editing of hepatitis delta virus antigenome by dsRNA-adenosine deaminase

1996 • 336 citations

Interferon Regulatory Factor 3 and CREB-Binding Protein/p300 Are Subunits of Double-Stranded RNA-Activated Transcription Factor DRAF1

1998 • 334 citations

Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either.

1990 • 332 citations

Poliovirus proteinase 2A induces cleavage of eucaryotic initiation factor 4F polypeptide p220

1987 • 329 citations

Intragenic pausing and anti-sense transcription within the murine c-myc locus.

1986 • 326 citations

Interferon action—sequence specificity of the ppp(A2′p)nA-dependent ribonuclease

1981 • 321 citations

Antisense RNA injections in fertilized frog eggs reveal an RNA duplex unwinding activity

1987 • 320 citations

A double-stranded RNA unwinding activity introduces structural alterations by means of adenosine to inosine conversions in mammalian cells and Xenopus eggs.

1989 • 318 citations

Double-stranded RNA activates binding of NF-kappa B to an inducible element in the human beta-interferon promoter.

1989 • 317 citations

A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit.

1989 • 316 citations

Sno Storm in the Nucleolus: New Roles for Myriad Small RNPs

1997 • 314 citations

An antisense mRNA directs the covalent modification of the transcript encoding fibroblast growth factor in Xenopus oocytes

1989 • 305 citations

THE MOLECULAR BIOLOGY OF HEPATITIS DELTA VIRUS

1995 • 301 citations

Autophosphorylation of the protein kinase dependent on double-stranded RNA.

1987 • 301 citations

Preferential selection of adenosines for modification by double-stranded RNA adenosine deaminase.

1994 • 297 citations

Human β-interferon gene expression is regulated by an inducible enhancer element

1985 • 283 citations

Differential Expression of c- myb mRNA in Murine B Lymphomas by a Block to Transcription Elongation

1987 • 279 citations

Structure of the dsRNA binding domain of E. coli RNase III.

1995 • 279 citations

Post-transcriptional control of myc and p53 expression during differentiation of the embryonal carcinoma cell line F9

1985 • 274 citations

A cellular protein that binds to the 5'-noncoding region of poliovirus RNA: implications for internal translation initiation.

1989 • 271 citations

Inosine exists in mRNA at tissue-specific levels and is most abundant in brain mRNA

1998 • 265 citations

Mechanism of interferon action: Phosphorylation of protein synthesis initiation factor eIF-2 in interferon-treated human cells by a ribosome-associated kinase processing site specificity similar to hemin-regulated rabbit reticulocyte kinase

1979 • 263 citations

Platelet-derived growth factor and double-stranded ribonucleic acids stimulate expression of the same genes in 3T3 cells

1985 • 263 citations

A Study of the Interferon Antiviral Mechanism: Apoptosis Activation by the 2–5A System

1997 • 262 citations

NMR solution structure of a dsRNA binding domain from Drosophila staufen protein reveals homology to the N-terminal domain of ribosomal protein S5.

1995 • 262 citations

Involvement of the IRF family transcription factor IRF‐3 in virus‐induced activation of the IFN‐β gene

1998 • 262 citations

A specific base transition occurs on replicating hepatitis delta virus RNA

1990 • 260 citations

Cloning of cDNAs encoding mammalian double-stranded RNA-specific adenosine deaminase

1995 • 260 citations

Gene within a gene: Nested Drosophila genes encode unrelated proteins on opposite DNA strands

1986 • 251 citations

Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2

1997 • 248 citations

Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes.

1992 • 247 citations

Two RNA-binding motifs in the double-stranded RNA-activated protein kinase, DAI.

1992 • 243 citations

Water in Biological Systems

1971 • 242 citations

Overlapping positive and negative regulatory domains of the human beta-interferon gene.

1988 • 237 citations

Vaccinia virus-encoded elF-2α homolog abrogates the antiviral effect of interferon

1991 • 233 citations

Interferon-β gene regulation: Tandemly repeated sequences of a synthetic 6 bp oligomer function as a virus-inducible enhancer

1987 • 233 citations

Antisense RNA: its functions and applications in gene regulation — a review

1988 • 230 citations

The Role of RNA Editing in Controlling Glutamate Receptor Channel Properties

1996 • 230 citations

Four different forms of interferon-induced 2',5'-oligo(A) synthetase identified by immunoblotting in human cells.

1987 • 229 citations

PKR: a new name and new roles

1995 • 223 citations

Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR

1997 • 223 citations

Minor-Groove Recognition of Double-Stranded RNA by the Double-Stranded RNA-Binding Domain from the RNA-Activated Protein Kinase PKR

1996 • 222 citations

Delimitation and properties of DNA sequence: required for the regulated expression of human interferon-β gene

1985 • 216 citations

Activation of the human "beta 2-interferon/hepatocyte-stimulating factor/interleukin 6" promoter by cytokines, viruses, and second messenger agonists.

1988 • 215 citations

TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR.

1994 • 215 citations

Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system.

1991 • 207 citations

The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2

1992 • 207 citations

Inhibitory activity for the interferon-induced protein kinase is associated with the reovirus serotype 1 sigma 3 protein.

1988 • 204 citations

Double-Stranded Poliovirus RNA Inhibits Initiation of Protein Synthesis by Reticulocyte Lysates

1971 • 204 citations

The Double Stranded RNA-Activated Protein Kinase Induced by Interferon: dsRNA-PK

1989 • 202 citations

The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed

1994 • 200 citations

Nuclear antisense RNA induces extensive adenosine modifications and nuclear retention of target transcripts

1997 • 196 citations

Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: A novel translational control mechanism

1989 • 196 citations

Two Mammalian Genes Transcribed from Opposite Strands of the Same DNA Locus

1987 • 195 citations

Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene

1995 • 193 citations

Binding of influenza A virus NS1 protein to dsRNA in vitro

1992 • 190 citations

A mouse locus at which transcription from both DNA strands produces mRNAs complementary at their 3′ ends

1986 • 187 citations

Early events in signalling by interferons

1993 • 186 citations

A 46-nucleotide promoter segment from an IFN-α gene renders an unrelated promoter inducible by virus

1985 • 185 citations

The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation

1989 • 184 citations

Inhibition of c-erbA mRNA splicing by a naturally occurring antisense RNA.

1991 • 184 citations

Hepatitis D virus RNA editing: specific modification of adenosine in the antigenomic RNA

1995 • 182 citations

Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase.

1992 • 176 citations

Comparative analysis of the regulation of the interferoninducible protein kinase PKR by Epstein - Barr virus RNAs EBER-1 and EBER-2 and adenovirus VA, RNA

1993 • 175 citations

Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways

1997 • 174 citations

N-myc mRNA Forms an RNA-RNA Duplex with Endogenous Antisense Transcripts

1990 • 173 citations

Virus-specific RNA in cells productively infected or transformed by polyoma virus

1966 • 171 citations

Epstein-Barr virus small RNA (EBER) genes: Unique transcription units that combine RNA polymerase II and III promoter elements

1989 • 170 citations

Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo.

1995 • 165 citations

Purification and partial characterization of a cellular inhibitor of the interferon-induced protein kinase of Mr 68,000 from influenza virus-infected cells.

1990 • 164 citations

Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation

1997 • 163 citations

The 58,000-Dalton Cellular Inhibitor of the Interferon-Induced Double-Stranded RNA-Activated Protein Kinase (PKR) Is a member of the Tetratricopeptide Repeat Family of Proteins

1994 • 162 citations

Mechanism of Interferon Action

1996 • 161 citations

Strong conservation of non-coding sequences during vertebrates evolution: potential involvement in post-transcriptional regulation of gene expression

1993 • 160 citations

Overlapping transcription units in the dopa decarboxylase region of Drosophila

1986 • 158 citations

Different pathways mediate virus inducibility of the human IFN-α1 and IFN-β genes

1990 • 158 citations

Structural Requirements for RNA Editing in Glutamate Receptor Pre-mRNAs by Recombinant Double-stranded RNA Adenosine Deaminase

1996 • 157 citations

Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences.

1996 • 155 citations

Mechanism of Interferon Action: Double-Stranded RNA-Specific Adenosine Deaminase from Human Cells Is Inducible by Alpha and Gamma Interferons

1995 • 154 citations

Interaction between VA RNA and the lupus antigen La: formation of a ribonucleoprotein particle in vitro.

1982 • 154 citations

Intermolecular duplexes in heterogeneous nuclear RNA from HeLa cells

1977 • 153 citations

HIV-1 Tat Directly Interacts with the Interferon-Induced, Double-Stranded RNA-Dependent Kinase, PKR

1995 • 149 citations

The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo.

1995 • 147 citations

The Tat Protein of Human Immunodeficiency Virus Type 1 Is a Substrate and Inhibitor of the Interferon-induced, Virally Activated Protein Kinase, PKR

1997 • 146 citations

The mechanism of adenosine to inosine conversion by the double-stranded RNA unwinding/modifying activity: a high-performance liquid chromatography-mass spectrometry analysis

1991 • 146 citations

HIV-1 TAR RNA Has an Intrinsic Ability to Activate Interferon-Inducible Enzymes

1994 • 142 citations

An Overview of the Interferon System: Signal Transduction and Mechanisms of Action

1996 • 142 citations

Differential antisense transcription from the Dictyostelium EB4 gene locus: Implications on antisense-mediated regulation of mRNA stability

1992 • 140 citations

Transcriptional Induction by Double-stranded RNA Is Mediated by Interferon-stimulated Response Elements without Activation of Interferon-stimulated Gene Factor 3

1995 • 139 citations

Transcription during productive infection with polyoma virus and simian virus 40

1976 • 138 citations

Activation of interferon-regulated, dsRNA-dependent enzymes by human immunodeficiency virus-1 leader RNA

1989 • 135 citations

Cap recap: The involvement of eIF-4F in regulating gene expression

1992 • 134 citations

Tat-responsive region RNA of human immunodeficiency virus 1 can prevent activation of the double-stranded-RNA-activated protein kinase.

1990 • 131 citations

Chicken double-stranded RNA adenosine deaminase has apparent specificity for Z-DNA.

1995 • 130 citations

Glycosylation of eukaryotic peptide chain initiation factor 2 (eIF-2)-associated 67-kDa polypeptide (p67) and its possible role in the inhibition of eIF-2 kinase-catalyzed phosphorylation of the eIF-2 α-subunit

1989 • 129 citations

Functionally Distinct Double-stranded RNA-binding Domains Associated with Alternative Splice Site Variants of the Interferon-inducible Double-stranded RNA-specific Adenosine Deaminase

1997 • 129 citations

Nuclear Localization of a Double-Stranded RNA-Binding Protein Encoded by the Vaccinia Virus E3L Gene

1993 • 128 citations

Relatedness of an RNA-Binding Motif in Human Immunodeficiency Virus Type 1 TAR RNA-Binding Protein TRBP to Human P1/dsI Kinase and Drosophila Staufen

1993 • 126 citations

Characterization of a vaccinia virus-encoded double-stranded RNA-binding protein that may be involved in inhibition of the double-stranded rna-dependent protein kinase

1991 • 125 citations

Cell cycle expression of RNA duplex unwindase activity in mammalian cells.

1988 • 125 citations

The 58-kilodalton inhibitor of the interferon-induced double-stranded RNA-activated protein kinase is a tetratricopeptide repeat protein with oncogenic properties.

1994 • 122 citations

Identification of the double-stranded RNA-binding domain of the human interferon-inducible protein kinase.

1992 • 121 citations

Vesicular stomatitis virus defective interfering particles can contain extensive genomic sequence rearrangements and base substitutions

1984 • 120 citations

Regulation of gene expression by natural antisense RNA transcripts

1997 • 120 citations

Reversible silencing of enhancers by sequences derived from the human IFN-α promoter

1987 • 119 citations

Synthesis of (2'-5')oligoadenylate and activation of an endoribonuclease in interferon-treated HeLa cells infected with reovirus

1982 • 118 citations

Characterization of the double-stranded RNA implicated in the inhibition of protein synthesis in cells infected with a mutant adenovirus defective for VA RNA

1988 • 116 citations

Mechanism of interferon action: cDNA structure, expression, and regulation of the interferon-induced, RNA-dependent P1/eIF-2α protein kinase from human cells

1992 • 116 citations

Virus-specific early RNA in 3T6 cells infected by a tsA mutant of polyoma virus

1978 • 114 citations

Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase.

1994 • 114 citations

Rescue of vaccinia virus lacking the E3L gene by mutants of E3L

1995 • 113 citations

Nuclear Localization of the Interferon-Inducible Protein Kinase PKR in Human Cells and Transfected Mouse Cells

1995 • 112 citations

RNA synthesis in cells infected with herpes simplex virus. X. Properties of viral symmetric transcripts and of double-stranded RNA prepared from them

1975 • 111 citations

2'5'Oligo(A) polymerase activity and inhibition of viral RNA synthesis in interferon-treated HeLa cells

1979 • 111 citations

Purification and Cloning of Interferon-Stimulated Gene Factor 2 (ISGF2): ISGF2 (IRF-1) Can Bind to the Promoters of Both Beta Interferon- and Interferon-Stimulated Genes but Is Not a Primary Transcriptional Activator of Either

1990 • 110 citations

New inducers revealed by the promoter sequence analysis of two interferon-activated human genes

1987 • 110 citations

Autophosphorylation Sites Participate in the Activation of the Double-Stranded-RNA-Activated Protein Kinase PKR

1996 • 110 citations

Purification of the Xenopus laevis double-stranded RNA adenosine deaminase

1994 • 110 citations

Distinct Patterns of IFN Sensitivity Observed in Cells Infected with Vaccinia K3L- and E3L- Mutant Viruses

1995 • 110 citations

Oncogenic ras induces an inhibitor of double-stranded RNA-dependent eukaryotic initiation factor 2 alpha-kinase activation

1992 • 109 citations

Two classes of translational control RNA: their role in the regulation of protein synthesis.

1975 • 109 citations

Expression of the thyroid hormone receptor gene, erbA , in B lymphocytes: Alternative mRNA processing is independent of differentiation but correlates with antisense RNA levels

1997 • 108 citations

Influenza virus regulates protein synthesis during infection by repressing autophosphorylation and activity of the cellular 68,000-Mr protein kinase

1988 • 108 citations

Coordinate viral induction of tumor necrosis factor alpha and interferon beta in human B cells and monocytes.

1989 • 108 citations

Virus-specific RNA in Cells Productively Infected or Transformed by Polyoma Virus

1974 • 108 citations

An ATF/CREB binding site is required for virus induction of the human interferon beta gene [corrected]

1992 • 107 citations

Host-range restriction of vaccinia virus E3L-specific deletion mutants

1996 • 106 citations

Functional Characterization of the RNA-binding Domain and Motif of the Double-stranded RNA-dependent Protein Kinase DAI (PKR)

1995 • 105 citations

Double-stranded RNA activates novel factors that bind to the interferon-stimulated response element.

1993 • 105 citations

Naturally occurring antisense RNA control — a brief review

1988 • 105 citations

Characterization and regulation of the 58,000-dalton cellular inhibitor of the interferon-induced, dsRNA-activated protein kinase.

1992 • 101 citations

Human 2-5A synthetase: characterization of a novel cDNA and corresponding gene structure.

1985 • 98 citations

An amino-terminal polypeptide fragment of the influenza virus NS1 protein possesses specific RNA-binding activity and largely helical backbone structure.

1995 • 97 citations

Generation and Properties of Measles Virus Mutations Typically Associated with Subacute Sclerosing Panencephalitis^a

1994 • 97 citations

Loss of Conserved Cysteine Residues in the Attachment (G) Glycoprotein of Two Human Respiratory Syncytial Virus Escape Mutants That Contain Multiple A-G Substitutions (Hypermutations)

1994 • 95 citations

Double-stranded RNA unwinding and modifying activity is detected ubiquitously in primary tissues and cell lines.

1990 • 95 citations

The regulation of the protein kinase PKR by RNA

1996 • 94 citations

Purification of Human Double-stranded RNA-specific Editase 1 (hRED1) Involved in Editing of Brain Glutamate Receptor B Pre-mRNA

1997 • 94 citations

Hepatitis Delta Virus RNA Editing Is Highly Specific for the Amber/W Site and Is Suppressed by Hepatitis Delta Antigen

1998 • 94 citations

The eukaryotic initiation factor 2-associated 67-kDa polypeptide (p67) plays a critical role in regulation of protein synthesis initiation in animal cells.

1992 • 94 citations

Cytosolic double-stranded RNA-dependent protein kinase is likely a dimer of partially phosphorylated Mr = 66,000 subunits.

1992 • 93 citations

An antisense RNA involved in p53 mRNA maturation in murine erythroleukemia cells induced to differentiate.

1989 • 93 citations

Characterization of Rubella Virus Replication Complexes Using Antibodies to Double-Stranded RNA

1994 • 93 citations

Mechanism of interferon action activation of the human P1/eIF-2α protein kinase by individual reovirus s-class mRNAs: s1 mRNA is a potent activator relative to s4 mRNA

1989 • 92 citations

Negative-strand RNA transcripts are produced in human immunodeficiency virus type 1-infected cells and patients by a novel promoter downregulated by Tat

1994 • 91 citations

Transcription of the Polyoma Virus Genome: Synthesis and Cleavage of Giant Late Polyoma-Specific RNA

1971 • 91 citations

Cytoplasm from Poliovirus-infected HeLa Cells inhibits Cell-free Haemoglobin Synthesis

1971 • 90 citations

Intron sequence directs RNA editing of the glutamate receptor subunit GluR2 coding sequence.

1994 • 87 citations

Extensive Symmetrical Transcription of Simian Virus 40 DNA in Virus-Yielding Cells

1972 • 87 citations

Intermolecular duplexes formed from polyadenylylated vaccinia virus RNA

1979 • 86 citations

Making (anti)sense of non-coding sequence conservation

1997 • 85 citations

Mutations and A/I Hypermutations in Measles Virus Persistent Infections

1992 • 84 citations

Sequence, Organization, and Transcription of theDlx-1andDlx-2Locus

1996 • 84 citations

Transcriptional activation of immunoglobulin α heavy-chain genes by translocation of the c-myc oncogene

1983 • 84 citations

Interactions between the double-stranded RNA binding motif and RNA: definition of the binding site for the interferon-induced protein kinase DAI (PKR) on adenovirus VA RNA.

1995 • 83 citations

Regulation of Interferon-Induced Protein Kinase PKR: Modulation of P58^IPK Inhibitory Function by a Novel Protein, P52^rIPK

1998 • 83 citations

The P58 Cellular Inhibitor Complexes with the Interferon-induced, Double-stranded RNA-dependent Protein Kinase, PKR, to Regulate Its Autophosphorylation and Activity

1996 • 82 citations

Modulation of Nuclear Matrix-associated 2′,5′-Oligoadenylate Metabolism and Ribonuclease L Activity in H9 Cells by Human Immunodeficiency Virus

1989 • 82 citations

Characterization of Specific DNA-binding Factors Activated by Double-stranded RNA as Positive Regulators of Interferon α/β-stimulated Genes

1995 • 82 citations

The PKR protein kinase--an interferon-inducible regulator of cell growth and differentiation.

1997 • 81 citations

Expression of Alternatively Spliced bFGF First Coding Exons and Antisense mRNAs during Chicken Embryogenesis

1993 • 80 citations

Mechanism of interferon action: functionally distinct RNA-binding and catalytic domains in the interferon-inducible, double-stranded RNA-specific adenosine deaminase

1996 • 80 citations

Biased (A→I) hypermutation of animal RNA virus genomes

1994 • 80 citations

An antisense transcript from the Xenopus laevis bFGF gene coding for an evolutionarily conserved 24 kd protein.

1989 • 79 citations

Signaling by the Cytokine Receptor Superfamily in Normal and Transformed Hematopoietic Cells

1996 • 79 citations

Mechanism of Synthesis of Vaccinia Virus Double-Stranded Ribonucleic Acid In Vivo and In Vitro

1971 • 79 citations

Tumor necrosis factor acts synergistically with autocrine interferon-β and increases interferon-β mRNA levels in human fibroblasts

1989 • 76 citations

The phosphoprotein p53 is down-regulated post-transcriptionally during embryogenesis in vertebrates

1988 • 76 citations

Regulation of two interferon‐inducible human genes by interferon, poly(rI) · poly(rC) and viruses

1988 • 74 citations

Heterochronic genes and the temporal control of C. elegans development

1994 • 74 citations

Polyoma virus giant RNAs contain tandem repeats of the nucleotide sequence of the entire viral genome.

1978 • 73 citations

Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells.

1988 • 73 citations

Gene expression from the c-erbA alpha/Rev-ErbA alpha genomic locus. Potential regulation of alternative splicing by opposite strand transcription.

1990 • 71 citations

Purification of myosin translational control RNA and its interaction with myosin messenger RNA

1976 • 70 citations

Binding of Tat Protein to TAR Region of Human Immunodeficiency Virus Type 1 Blocks TAR-Mediated Activation of (2′-5′)Oligoadenylate Synthetase

1990 • 69 citations

A ribonuclease specific for inosine-containing RNA: a potential role in antiviral defence?

1997 • 68 citations

Tat-responsive region RNA of human immunodeficiency virus type 1 stimulates protein synthesis in vivo and in vitro: relationship between structure and function.

1992 • 67 citations

Organization of the double-stranded rna-activated protein kinase dai and virus-associated va rnai in adenovirus-2-infected hela cells

1993 • 67 citations

Activation of the Double‐Stranded‐RNA‐Activated Protein Kinase and Induction of Vascular Cell Adhesion Molecule‐1 by Poly (I) · Poly (C) in Endothelial Cells

1995 • 67 citations

TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine

1991 • 67 citations

RNA Synthesis in cells infected with herpes simplex virus

1970 • 66 citations

Viral evasion of cellular defense mechanisms: regulation of the protein kinase DAI by RNA effectors

1993 • 66 citations

Synthesis of Complementary RNA Sequences During Productive Adenovirus Infection

1974 • 66 citations

Activation of Interferon-inducible 2′ −5′ Oligoadenylate Synthetase by Adenoviral VAI RNA

1995 • 64 citations

Mechanism of interferon action: characterization of the intermolecular autophosphorylation of PKR, the interferon-inducible, RNA-dependent protein kinase

1995 • 64 citations

Presence of 2',5'-oligo(A) and of enzymes that synthesize, bind, and degrade 2',5'-oligo(A) in HeLa cell nuclei.

1982 • 64 citations

Independent regulation of transcription of the two strands of the c-myc gene.

1987 • 63 citations

Proteins that interact with PKR

1994 • 63 citations

Vaccinia specific kinase inhibitory factor prevents translational inhibition by double-stranded RNA in rabbit reticulocyte lysate

1989 • 63 citations

Numerous transitions in human parainfluenza virus 3 RNA recovered from persistently infected cells

1991 • 62 citations

Basic Fibroblast Growth Factor Sense (FGF) and Antisense (GFG) RNA Transcripts Are Expressed in Unfertilized Human Oocytes and in Differentiated Adult Tissues

1994 • 62 citations

Regulation of the interferon-inducible eIF-2α protein kinase by small RNAs

1994 • 61 citations

Regulation of polyomavirus transcription by large tumor antigen.

1984 • 60 citations

Naturally Occurring Antisense Transcripts Are Present in Chick Embryo Chondrocytes Simultaneously with the Down-regulation of the α1(I) Collagen Gene

1995 • 60 citations

The La antigen inhibits the activation of the interferoninducible protein kinase PKR by sequestering and unwinding double-stranded RNA

1994 • 59 citations

Characterization of a temperature-sensitive mutant of vaccinia virus reveals a novel function that prevents virus-induced breakdown of RNA

1985 • 57 citations

Functional Expression and RNA Binding Analysis of the Interferon-Induced, Double-Stranded RNA-Activated, 68,000-M_r Protein Kinase in a Cell-Free System

1991 • 56 citations

The mouse surfeit locus contains a very tight cluster of four "housekeeping" genes that is conserved through evolution.

1988 • 56 citations

Tat-dependent adenosine-to-inosine modification of wild-type transactivation response RNA.

1991 • 56 citations

Secondary structure of heterogeneous nuclear RNA: Two classes of double-stranded RNA in native ribonucleoprotein

1977 • 56 citations

Characterization of translational-control ribonucleic acid isolated from embryonic chick muscle

1983 • 55 citations

Identification and Partial Purification of Human Double Strand RNase Activity

1998 • 54 citations

Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene.

1994 • 54 citations

Characterization and tissue-specific expression of the rat basic fibroblast growth factor antisense mRNA and protein

1997 • 54 citations

tcRNA as a naturally occurring antisense RNA in eukaryotes

1986 • 53 citations

Strand-Specific Transcription of Polyoma Virus DNA Early in Productive Infection and in Transformed Cells

1976 • 51 citations

The cytoplasm of Xenopus oocytes contains a factor that protects double-stranded RNA from adenosine-to-inosine modification.

1994 • 51 citations

Role of sequences within the first intron in the regulation of expression of eukaryotic initiation factor 2 alpha.

1992 • 51 citations

Inhibition of Cellular Protein Synthesis by Double-Stranded RNA: Inactivation of an Initiation Factor

1973 • 51 citations

Games viruses play: a strategic initiative against the interferon-induced dsRNA activated 68,000 Mr protein kinase

1993 • 50 citations

RNA Editing inDrosophila 4f-rnpGene Nuclear Transcripts by Multiple A-to-G Conversions

1996 • 50 citations

Modification of retroviral RNA by double-stranded RNA adenosine deaminase

1995 • 50 citations

Antisense transcripts and protein binding motifs within the Wilms tumour (WT1) locus.

1994 • 50 citations

Analysis of polyoma virus nuclear RNA by mini-blot hybridization.

1977 • 49 citations

Post-transcriptional events are responsible for low expression of myelin basic protein in myelin deficient mice: role of natural antisense RNA.

1990 • 49 citations

Activation of the double-stranded RNA (dsRNA)-activated human protein kinase in vivo in the absence of its dsRNA binding domain.

1994 • 49 citations

The small RNAs of Epstein-Barr virus

1993 • 49 citations

Activation of 2',5'-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells by 2'-O-methylated poly (inosinic acid) . poly(cytidylic acid), Correlations with interferon-inducing activity.

1980 • 47 citations

Signal transduction and activation of gene transcription by interferons.

1995 • 47 citations

Expression of the rat BFGF antisense RNA transcript is tissue-specific and developmentally regulated

1996 • 47 citations

Double-Stranded RNA and Interferon Action

1987 • 47 citations

Identification of antisense transcripts of the chicken insulin-like growth factor-II gene

1991 • 46 citations

Myelin Basic Protein Gene and the Function of Antisense RNA in Its Repression in Myelin‐Deficient Mutant Mouse

1991 • 46 citations

Partial characterization of a cellular factor that regulates the double-stranded RNA-dependent eIF-2 alpha kinase in 3T3-F442A fibroblasts.

1991 • 46 citations

Characterization of two murine (2′‐5′)(A)_n‐dependent endonucleases of different molecular mass

1989 • 46 citations

Double-stranded RNA adenosine deaminase as a potential mammalian RNA editing factor

1993 • 46 citations

Polyomavirus early-late switch is not regulated at the level of transcription initiation and is associated with changes in RNA processing.

1988 • 46 citations

The polyoma virus T antigen interferes with interferon-inducible gene expression

1998 • 44 citations

Increased eIF-2 alpha expression in mitogen-activated primary T lymphocytes.

1990 • 43 citations

An antisense promoter of the murine c-myc gene is localized within intron 2.

1992 • 43 citations

Mechanism of action of a cellular inhibitor of the dsRNA-dependent protein kinase from 3T3-F442A cells.

1992 • 42 citations

Isolation of a cDNA Encoding Human Rev-ErbAα: Transcription from the Noncoding DNA Strand of a Thyroid Hormone Receptor Gene Results in a Related Protein That Does Not Bind Thyroid Hormone

1990 • 42 citations

Kinetics and efficiency of polyadenylation of late polyomavirus nuclear RNA: generation of oligomeric polyadenylated RNAs and their processing into mRNA.

1984 • 42 citations

Conserved pattern of antisense overlapping transcription in the homologous human ERCC-1 and yeast RAD10 DNA repair gene regions.

1989 • 42 citations

Early events in murine erythroleukemia cells induced to differentiate

1988 • 41 citations

Regulation of the Double-stranded RNA-Dependent Protein Kinase PKR by RNAs Encoded by a Repeated Sequence in the Epstein-Barr Virus Genome

1996 • 41 citations

The Basic Fibroblast Growth Factor (FGF-2) Antisense RNA (GFG) Is Translated into a MutT-Related Proteinin Vivo

1996 • 40 citations

Structure of polyoma virus late nuclear RNA

1981 • 39 citations

Cell Cycle Expression of RNA Duplex Unwindase Activity in Mammalian Cells

1988 • 39 citations

Studies Concerning the Mechanism by which Translational‐Control RNA Regulates Protein Synthesis in Embryonic Muscle

1975 • 39 citations

Double-Stranded Ribonuclease Coinduced with Interferon

1989 • 38 citations

Structure and expression of the vaccinia virus gene which prevents virus-induced breakdown of RNA

1990 • 38 citations

Functional and biological properties of an avian variant long terminal repeat containing multiple A to G conversions in the U3 sequence

1994 • 38 citations

Double-Stranded RNA Activates Novel Factors That Bind to the Interferon-Stimulated Response Element

1993 • 37 citations

Nuclear and cytoplasmic sites for anti-sense control

1989 • 36 citations

Protein kinases that phosphorylate eIF-2 and eIF-2B, and their role in eukaryotic cell translational control.

1996 • 36 citations

The Mouse Genes for the EP1Prostanoid Receptor and the PKN Protein Kinase Overlap

1996 • 36 citations

Identification of a 90-kDa polypeptide which associates with adenovirus VA RNAI and is phosphorylated by the double-stranded RNA-dependent protein kinase

1989 • 36 citations

Mitogenic effect of double‐stranded RNA in human fibroblasts: Role of autogenous interferon

1987 • 36 citations

Modulation of ppp(A2'p)nA-dependent RNase by a temperature-sensitive mutant of vaccinia virus

1989 • 33 citations

Two Molecular Weight Forms of Human 2′,5′-Oligoadenylate Synthetase Have Different Activation Requirements

1986 • 33 citations

Differential effect of poly rI·rC and Newcastle disease virus on the expression of interferon and cellular genes in mouse cells

1985 • 33 citations

Double-Stranded RNA Unwinding and Modifying Activity Is Detected Ubiquitously in Primary Tissues and Cell Lines

1990 • 33 citations

Characterization of an antisense Inr element in the eIF-2 alpha gene.

1994 • 33 citations

Polyomavirus late pre-mRNA processing: DNA replication-associated changes in leader exon multiplicity suggest a role for leader-to-leader splicing in the early-late switch

1990 • 33 citations

Recombination within the upstream gene of duplicated myelin basic protein genes of myelin deficient shimld mouse results in the production of antisense RNA.

1988 • 33 citations

Sensitivity and resistance of human tumour cells to interferon rIn ·rCn

1982 • 32 citations

Polyoma virus early-late switch: regulation of late RNA accumulation by DNA replication.

1993 • 31 citations

Antisense techniques: an overview.

1992 • 30 citations

Evidence for a novel signal transduction pathway activated by platelet-derived growth factor and by double-stranded RNA.

1989 • 30 citations

Interacting pathways of interferon signaling.

1997 • 29 citations

Alteration of Nuclear (2´-5´) Oligoriboadenylate Synthetase and Nuclease Activities Preceding Replication of Human Immunodeficiency Virus in H9 Cells

1988 • 28 citations

Changes in the topography of early region transcription during polyoma virus lytic infection.

1982 • 27 citations

Identification of an antisense transcript from the IGF‐II locus in mouse

1993 • 27 citations

Regulation of polyoma virus early transcription in transformed cells by large T-antigen

1982 • 26 citations

Kinetics and Efficiency of Polyadenylation of Late Polyomavirus Nuclear RNA: Generation of Oligomeric Polyadenylated RNAs and Their Processing into mRNA

1984 • 25 citations

Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene

1994 • 25 citations

RNA Editing of aDrosophilaSodium Channel Gene

1999 • 24 citations

Effects of IL-3 on promoter usage, attenuation and antisense transcription of the c-myc oncogene in the IL-3-dependent Ba/F3 early pre-B cell line.

1991 • 23 citations

Interferon-sensitivity of the enhanced incorporation of thymidine into cellular DNA induced by polyoma virus

1970 • 23 citations

Polyoma virus transcription early during productive infection of mouse 3T6 cells

1979 • 23 citations

Inhibition of the dsRNA-Dependent Protein Kinase by a Peptide Derived from the Human Immunodeficiency Virus Type 1 Tat Protein

1993 • 22 citations

Sense and antisense transcripts of the developmentally regulated murine hsp70.2 gene are expressed in distinct and only partially overlapping areas in the adult brain

1996 • 22 citations

Synergistic antiproliferative effect of human interferons in combination with mismatched double‐stranded RNA on human tumor cells

1986 • 21 citations

Cellular Inhibitors of the Interferon-Induced, dsRNA-Activated Protein Kinase

1994 • 21 citations

Modulation of Double‐Stranded RNAs in Vivo by RNA Duplex Unwindasea

1992 • 20 citations

Effect of Interferon on Some Aspects of Transformation by Polyoma Virus

1971 • 20 citations

Antisense RNA and p53 Regulation in Induced Murine Cell Differentiation

1992 • 20 citations

Efficiency of processing of viral RNA during the early and late phases of productive infection by polyoma virus

1981 • 19 citations

Effects of Maternal Preimmunization on the Decidual Cell Reaction in Mice

1971 • 19 citations

Bass, B. L. et al. A standardized nomenclature for adenosine deaminases that act on RNA. RNA 3, 947-949

1997 • 19 citations

RNA Editing: RNA duplexes guide base conversions

1994 • 19 citations

Effect on platelet‐derived growth factor‐induced mitogenesis of double‐stranded RNA: Evidence for an autocrine growth inhibition mediated by interferon‐β

1988 • 17 citations

Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes.

1990 • 15 citations

The Cytoplasm of Xenopus Oocytes Contains a Factor That Protects Double-Stranded RNA from Adenosine-to-Inosine Modification

1994 • 14 citations

Earth sciences: Suspect Sm-Nd whole-rock ages

1984 • 12 citations

Partial Characterization of a Cellular Factor That Regulates the Double-Stranded RNA-Dependent eIF-2α Kinase in 3T3-F442A Fibroblasts

1991 • 11 citations

Conserved Pattern of Antisense Overlapping Transcription in the Homologous Human ERCC-1 and Yeast RAD10 DNA Repair Gene Regions

1989 • 11 citations

An Antisense Promoter of the Murine c-myc Gene Is Localized within Intron 2

1992 • 11 citations

Independent Regulation of Transcription of the Two Strands of the c-myc Gene

1987 • 11 citations

Nuclear proteins bind to poliovirus 5' untranslated region.

1996 • 10 citations

A Novel Member of the Thyroid/Steroid Hormone Receptor Family Is Encoded by the Opposite Strand of the Rat c-erbAα Transcriptional Unit

1989 • 9 citations

Characterization of an Interferon-Induced 48-kD Protein Immunologically Related to the Double-Stranded RNA-Activated Protein Kinase PKR

1994 • 9 citations

Receptor to nucleus signaling via tyrosine phosphorylation of the p91 transcription factor

1994 • 9 citations

Expression of naturally occurring RNA molecules complementary to the murine L27' ribosomal protein mRNA

1988 • 8 citations

Differential Activity of the 30-kD and the 100-kD Forms of 2′-5′A_nSynthetase Induced by Recombinant Human Interferon-α and Interferon-γ

1988 • 7 citations

The interferon inducer moiety of viruses: a single molecule of dsRNA.

1981 • 7 citations

Regulation of eukaryotic gene expression by naturally occurring antisense RNA.

1992 • 6 citations

Regulation of eukaryotic gene expression by natural antisense transcripts. The case of the modifying reaction.

1992 • 5 citations

Distinct epitopes in eukaryotic initiation factor 2 for binding of mRNA and for ternary complex formation with methionyl-tRNAf and GTP

1990 • 5 citations

Production and Susceptibility to Interferon of Polyoma Virus Variants of High and Low Oncogenic Properties<xref ref-type="fn" rid="FN2">2</xref>

1966 • 5 citations

Chimeric and Molecular Genetic Analysis of Myelin‐Deficient (Shiverer and Mld) Mutant Mice

1990 • 3 citations

Evidence for a Novel Signal Transduction Pathway Activated by Platelet-Derived Growth Factor and by Double-Stranded RNA

1989 • 3 citations

Induction of Interferon in Chick Cells by Polyoma Virus

1973 • 3 citations

Deleted Work

1955 • 0 citations