Proteins that interact with PKR

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1990 • 1,003 citations

Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme

1992 • 981 citations

The complete DNA sequence of vaccinia virus

1990 • 847 citations

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1992 • 543 citations

A repeating amino acid motif in CDC23 defines a family of proteins and a new relationship among genes required for mitosis and RNA synthesis

1990 • 507 citations

The involvement of NF-κB in β-interferon gene regulation reveals its role as widely inducible mediator of signal transduction

1989 • 494 citations

The TPR snap helix: a novel protein repeat motif from mitosis to transcription

1991 • 452 citations

Adenovirus virus-associated RNA and translation control

1991 • 387 citations

The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans.

1993 • 383 citations

Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2.

1992 • 325 citations

Double-stranded RNA activates binding of NF-kappa B to an inducible element in the human beta-interferon promoter.

1989 • 317 citations

Snap helix with knob and hole: Essential repeats in S. pombe nuclear protein nuc2 +

1990 • 306 citations

Autophosphorylation of the protein kinase dependent on double-stranded RNA.

1987 • 301 citations

Regulation of eukaryotic protein synthesis by initiation factors.

1993 • 300 citations

The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms

1993 • 265 citations

Platelet-derived growth factor and double-stranded ribonucleic acids stimulate expression of the same genes in 3T3 cells

1985 • 263 citations

Constitutive expression of human double-stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth

1992 • 238 citations

Vaccinia virus-encoded elF-2α homolog abrogates the antiviral effect of interferon

1991 • 233 citations

2-Aminopurine Selectively Inhibits the Induction of β-Interferon, c- fos , and c- myc Gene Expression

1988 • 233 citations

The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2

1992 • 207 citations

Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system.

1991 • 207 citations

Inhibitory activity for the interferon-induced protein kinase is associated with the reovirus serotype 1 sigma 3 protein.

1988 • 204 citations

Translational Regulation of Gene Expression 2

1993 • 202 citations

The Double Stranded RNA-Activated Protein Kinase Induced by Interferon: dsRNA-PK

1989 • 202 citations

Tumor-suppressor genes: news about the interferon connection.

1993 • 199 citations

The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation

1989 • 184 citations

Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinase

1993 • 183 citations

Reovirus-coded polypeptides in infected cells: Isolation of two native monomeric polypeptides with affinity for single-stranded and double-stranded RNA, respectively

1976 • 175 citations

Identification of a Conserved Motif That Is Necessary for Binding of the Vaccinia Virus E3L Gene Products to Double-Stranded RNA

1993 • 157 citations

Control of the Interferon-Induced 68-Kilodalton Protein Kinase by the HIV-1 tat Gene Product

1990 • 155 citations

Regulation of initiation factors during translational repression caused by serum depletion. Covalent modification.

1985 • 153 citations

The binding of double-stranded RNA and adenovirus VAI RNA to the interferon-induced protein kinase

1989 • 143 citations

The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins.

1994 • 136 citations

Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR

1993 • 132 citations

Nuclear Localization of a Double-Stranded RNA-Binding Protein Encoded by the Vaccinia Virus E3L Gene

1993 • 128 citations

Gene induction by interferons and double-stranded RNA: selective inhibition by 2-aminopurine.

1988 • 126 citations

Distinct binding sites for zinc and double-stranded RNA in the reovirus outer capsid protein sigma 3.

1988 • 124 citations

Characterization of a specific kinase inhibitory factor produced by vaccinia virus which inhibits the interferon-induced protein kinase

1984 • 114 citations

Two vaccinia virus proteins structurally related to the interleukin-1 receptor and the immunoglobulin superfamily

1991 • 110 citations

Oncogenic ras induces an inhibitor of double-stranded RNA-dependent eukaryotic initiation factor 2 alpha-kinase activation

1992 • 109 citations

Influenza virus regulates protein synthesis during infection by repressing autophosphorylation and activity of the cellular 68,000-Mr protein kinase

1988 • 108 citations

The War Against the Interferon-induced dsRNA-Activated Protein Kinase: Can Viruses Win?

1992 • 105 citations

Physiological stresses inhibit guanine‐nucleotide‐exchange factor in Ehrlich cells

1988 • 104 citations

Characterization and regulation of the 58,000-dalton cellular inhibitor of the interferon-induced, dsRNA-activated protein kinase.

1992 • 101 citations

Growth-related expression of a double-stranded RNA-dependent protein kinase in 3T3 cells.

1984 • 91 citations

Translational stimulation by reovirus polypeptide sigma 3: substitution for VAI RNA and inhibition of phosphorylation of the alpha subunit of eukaryotic initiation factor 2

1992 • 88 citations

Degradation of the interferon-induced 68,000-M(r) protein kinase by poliovirus requires RNA

1993 • 87 citations

Vaccinia rescue of VSV from interferon-induced resistance: Reversal of translation block and inhibition of protein kinase activity

1983 • 85 citations

Double-stranded RNA-dependent protein kinase and 2-5A system are both activated in interferon-treated, encephalomyocarditis virus-infected HeLa cells

1985 • 81 citations

Interferon Induction by Viruses. XVI. 2-Aminopurine Blocks Selectively and Reversibly an Early Stage in Interferon Induction

1988 • 80 citations

Inhibition of translation in cells infected with a poliovirus 2Apro mutant correlates with phosphorylation of the alpha subunit of eucaryotic initiation factor 2

1989 • 80 citations

Two interferon-induced proteins are involved in the protein kinase complex dependent on double-stranded RNA

1985 • 78 citations

TPR Proteins as Essential Components of the Yeast Cell Cycle

1991 • 77 citations

Inhibition of protein synthesis in reovirus-infected HeLa cells with elevated levels of interferon-induced protein kinase activity.

1982 • 76 citations

Interferon action against reovirus: activation of interferon-induced protein kinase in mouse L929 cells upon reovirus infection

1982 • 66 citations

Viral evasion of cellular defense mechanisms: regulation of the protein kinase DAI by RNA effectors

1993 • 66 citations

Vaccinia specific kinase inhibitory factor prevents translational inhibition by double-stranded RNA in rabbit reticulocyte lysate

1989 • 63 citations

Mechanism of interferon action. Characterization of sites of phosphorylation in the interferon-induced phosphoprotein P1 from mouse fibroblasts: evidence for two forms of P1.

1982 • 59 citations

Stimulation of chloramphenicol acetyltransferase mRNA translation by reovirus capsid polypeptide sigma 3 in cotransfected COS cells

1989 • 58 citations

Measures and countermeasures in the modulation of initiation factor activities by viruses.

1990 • 51 citations

PKR: Proposed Nomenclature for the RNA-Dependent Protein Kinase Induced by Interferon

1993 • 50 citations

Games viruses play: a strategic initiative against the interferon-induced dsRNA activated 68,000 Mr protein kinase

1993 • 50 citations

Multiple Protein-DNA Interactions within the Human Interferon-β Regulatory Element

1989 • 47 citations

Partial characterization of a cellular factor that regulates the double-stranded RNA-dependent eIF-2 alpha kinase in 3T3-F442A fibroblasts.

1991 • 46 citations

Interferon-induced dsRNA-activated protein kinase (PKR)*: antiproliferative, antiviral and antitumoral functions

1993 • 45 citations

Mechanism of action of a cellular inhibitor of the dsRNA-dependent protein kinase from 3T3-F442A cells.

1992 • 42 citations

Serum growth factors cause rapid stimulation of protein synthesis and dephosphorylation of eIF-2 in serum deprived Ehrlich cells

1989 • 39 citations

Reversal of the double‐stranded‐RNA‐induced inhibition of protein synthesis by a catalytically inactive mutant of the protein kinase PKR

1993 • 38 citations

Chromosomal Assignment of the Interferon-Inducible Double-Stranded RNA-Dependent Protein Kinase (PRKR) to Human Chromosome 2p21-p22 and Mouse Chromosome 17 E2

1993 • 36 citations

Identification of a 90-kDa polypeptide which associates with adenovirus VA RNAI and is phosphorylated by the double-stranded RNA-dependent protein kinase

1989 • 36 citations

Suppression with a difference

1992 • 32 citations

20 Translational Control and Cancer

2000 • 31 citations

A synthetic peptide substrate for initiation factor-2 kinases

1991 • 30 citations

Evidence for a novel signal transduction pathway activated by platelet-derived growth factor and by double-stranded RNA.

1989 • 30 citations

P21 v-ras inhibits induction of c-myc and c-fos expression by platelet-derived growth factor.

1988 • 27 citations

Expression of the Double-Stranded RNA-Dependent Protein Kinase (p68) in Squamous Cell Carcinoma of the Head and Neck Region

1993 • 27 citations

Viruses Launch their Own 'Star Wars'

1992 • 24 citations

Correlation of the expression of double-stranded RNA-dependent protein kinase (p68) with differentiation in head and neck squamous cell carcinoma

1993 • 21 citations

Cellular Inhibitors of the Interferon-Induced, dsRNA-Activated Protein Kinase

1994 • 21 citations

Mapping of the gene for interferon‐inducible dsRNA‐dependent protein kinase to chromosome region 2p21‐22: A site of rearrangements in myeloproliferative disorders

1993 • 17 citations

Inhibitor of Interferon‐Induced Double‐Stranded RNA‐ Dependent Protein Kinase and Its Relevance to Alteration of Cellular Protein Kinase Activity Level in Response to External Stimuli

1991 • 17 citations

Enhancement of the Interferon‐Induced Double‐Stranded RNA‐Dependent Protein Kinase Activity by Sindbis Virus Infection and Heat‐Shock Stress

1990 • 16 citations

The alpha subunit of eucaryotic initiation factor 2 is phosphorylated in mengovirus-infected mouse L cells

1990 • 14 citations

Regulation of GCN4 Expression in Yeast

1993 • 13 citations

Introduction to translational initiation factors and their regulation by phosphorylation

1993 • 10 citations

A kinase able to phosphorylate exogenous protein synthesis initiation factor eIF-2 alpha is present in lysates of mengovirus-infected L cells

1986 • 8 citations