The La antigen inhibits the activation of the interferoninducible protein kinase PKR by sequestering and unwinding double-stranded RNA

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

INTERFERONS AND THEIR ACTIONS

1987 • 1,838 citations

TRANSLATIONAL CONTROL IN MAMMALIAN CELLS

1991 • 1,041 citations

Phosphorylation of initiation factor eIF-2 and the control of reticulocyte protein synthesis

1977 • 750 citations

An unwinding activity that covalently modifies its double-stranded RNA substrate

1988 • 702 citations

Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F.

1990 • 632 citations

Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A.

1992 • 613 citations

Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities

1991 • 600 citations

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1992 • 543 citations

A conserved double-stranded RNA-binding domain.

1992 • 540 citations

La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate

1993 • 485 citations

The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase.

1992 • 469 citations

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase.

1993 • 436 citations

Adenovirus virus-associated RNA and translation control

1991 • 387 citations

Purified lupus antigen la recognizes an oligouridylate stretch common to the 3′ termini of RNA polymerase III transcripts

1984 • 382 citations

Initiation of protein synthesis in mammalian cells

1986 • 359 citations

Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III.

1989 • 340 citations

Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2.

1992 • 325 citations

Antisense RNA injections in fertilized frog eggs reveal an RNA duplex unwinding activity

1987 • 320 citations

Striking similarities are exhibited by two small Epstein-Barr virus-encoded ribonucleic acids and the adenovirus-associated ribonucleic acids VAI and VAII.

1981 • 315 citations

Autophosphorylation of the protein kinase dependent on double-stranded RNA.

1987 • 301 citations

The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis.

1993 • 280 citations

Two RNA-binding motifs in the double-stranded RNA-activated protein kinase, DAI.

1992 • 243 citations

Constitutive expression of human double-stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth

1992 • 238 citations

Structural analyses of EBER1 and EBER2 ribonucleoprotein particles present in Epstein-Barr virus-infected cells

1988 • 217 citations

Bidirectional RNA Helicase Activity of Eucaryotic Translation Initiation Factors 4A and 4F

1990 • 215 citations

Genomic structure and amino acid sequence domains of the human La autoantigen.

1988 • 210 citations

The RNA binding protein La influences both the accuracy and the efficiency of RNA polymerase III transcription in vitro.

1989 • 202 citations

Purification and activation of the double-stranded RNA-dependent eIF-2 kinase DAI.

1989 • 197 citations

Comparative analysis of the regulation of the interferoninducible protein kinase PKR by Epstein - Barr virus RNAs EBER-1 and EBER-2 and adenovirus VA, RNA

1993 • 175 citations

Purification and partial characterization of a cellular inhibitor of the interferon-induced protein kinase of Mr 68,000 from influenza virus-infected cells.

1990 • 164 citations

Interaction between VA RNA and the lupus antigen La: formation of a ribonucleoprotein particle in vitro.

1982 • 154 citations

The binding of double-stranded RNA and adenovirus VAI RNA to the interferon-induced protein kinase

1989 • 143 citations

The leader RNA of vesicular stomatitis virus is bound by a cellular protein reactive with anti-La lupus antibodies

1983 • 142 citations

Virus infection induces redistribution and membrane localization of the nuclear antigen La (SS-B): a possible mechanism for autoimmunity.

1989 • 136 citations

Striking Similarities Are Exhibited by Two Small Epstein-Barr Virus-Encoded Ribonucleic Acids and the Adenovirus-Associated Ribonucleic Acids VAI and VAII

1981 • 129 citations

Structure and regulation of eukaryotic initiation factor eIF-2. Sequence of the site in the alpha subunit phosphorylated by the haem-controlled repressor and by the double-stranded RNA-activated inhibitor

1987 • 129 citations

Characterization of a vaccinia virus-encoded double-stranded RNA-binding protein that may be involved in inhibition of the double-stranded rna-dependent protein kinase

1991 • 125 citations

Cell cycle expression of RNA duplex unwindase activity in mammalian cells.

1988 • 125 citations

Analysis of protein-RNA interactions within Ro ribonucleoprotein complexes

1991 • 119 citations

La Antigen Recognizes and Binds to the 3′-Oligouridylate Tail of a Small RNA

1984 • 115 citations

Characterization of the autoantigen La as a nucleic acid-dependent ATPase/dATPase with melting properties

1990 • 110 citations

Oncogenic ras induces an inhibitor of double-stranded RNA-dependent eukaryotic initiation factor 2 alpha-kinase activation

1992 • 109 citations

RNA unwinding in translation: assembly of helicase complex intermediates comprising eukaryotic initiation factors eIF-4F and eIF-4B.

1991 • 109 citations

The HRIGRXXR Region of the DEAD Box RNA Helicase Eukaryotic Translation Initiation Factor 4A Is Required for RNA Binding and ATP Hydrolysis

1993 • 108 citations

The War Against the Interferon-induced dsRNA-Activated Protein Kinase: Can Viruses Win?

1992 • 105 citations

Ro ribonucleoprotein assembly in vitro

1992 • 101 citations

Inhibition of protein synthesis in rabbit reticulocyte lysates by double-stranded RNA and oxidized glutathione: indirect mode of action on polypeptide chain initiation.

1975 • 101 citations

Characterization and regulation of the 58,000-dalton cellular inhibitor of the interferon-induced, dsRNA-activated protein kinase.

1992 • 101 citations

Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding

1989 • 100 citations

Subcellular distribution of Ro ribonucleoprotein complexes and their constituents

1993 • 96 citations

Structure and function of La and Ro RNPs

1993 • 95 citations

Nucleotide sequence and host La protein interactions of rabies virus leader RNA

1984 • 94 citations

ATP hydrolysis by initiation factor 4A is required for translation initiation in Saccharomyces cerevisiae.

1992 • 89 citations

Translational stimulation by reovirus polypeptide sigma 3: substitution for VAI RNA and inhibition of phosphorylation of the alpha subunit of eukaryotic initiation factor 2

1992 • 88 citations

A host protein (La) binds to a unique species of minus-sense leader RNA during replication of vesicular stomatitis virus.

1983 • 86 citations

Translational control by the Epstein‐Barr virus small RNA EBER‐1

1990 • 84 citations

Identification of a La protein binding site in a RNA polymerase III transcript (4.5 I RNA).

1983 • 81 citations

The La antigen shuttles between the nucleus and the cytoplasm in CV-1 cells

1989 • 73 citations

Localization of Epstein-Barr virus-encoded RNAs EBER-1 and EBER-2 in interphase and mitotic Burkitt lymphoma cells.

1992 • 67 citations

Organization of the double-stranded rna-activated protein kinase dai and virus-associated va rnai in adenovirus-2-infected hela cells

1993 • 67 citations

Purification and Activation of the Double-Stranded RNA-Dependent eIF-2 Kinase DAI

1989 • 64 citations

Intracellular Distribution of the La Antigen in CV-1 Cells after Herpes Simplex Virus Type 1 Infection Compared with the Localization of U Small Nuclear Ribonucleoprotein Particles

1989 • 61 citations

The small RNAs of Epstein-Barr virus

1993 • 49 citations

Modified subcellular localization of interferon-induced p68 kinase during encephalomyocarditis virus infection

1990 • 43 citations

Mechanism of action of a cellular inhibitor of the dsRNA-dependent protein kinase from 3T3-F442A cells.

1992 • 42 citations

Cell Cycle Expression of RNA Duplex Unwindase Activity in Mammalian Cells

1988 • 39 citations

Reversal of the double‐stranded‐RNA‐induced inhibition of protein synthesis by a catalytically inactive mutant of the protein kinase PKR

1993 • 38 citations

Structure and function of La and Ro RNPs

1990 • 38 citations

RNA Unwinding in Translation: Assembly of Helicase Complex Intermediates Comprising Eukaryotic Initiation Factors eIF-4F and eIF-4B

1991 • 35 citations

Sjögren's syndrome nuclear antigen B (La): cDNA cloning, structural domains, and autoepitopes

1989 • 31 citations

Occurrence of Novel Small RNAs with Concomitant Inhibition of Host Cellular U Small Nuclear RNA Synthesis in Vero Cells Infected with Herpes Simplex Virus Type 1

1986 • 23 citations

Modulation of Double‐Stranded RNAs in Vivo by RNA Duplex Unwindasea

1992 • 20 citations

Inhibitor of Interferon‐Induced Double‐Stranded RNA‐ Dependent Protein Kinase and Its Relevance to Alteration of Cellular Protein Kinase Activity Level in Response to External Stimuli

1991 • 17 citations

Interactions of plus and minus strand leader RNAs of the New Jersey serotype of vesicular stomatitis virus with the cellular La protein

1984 • 16 citations

La/SSB ribonucleoprotein levels increased in transformed cells

1991 • 11 citations

Antibodies against small nuclear ribonucleoproteins immunoprecipitate complexes containing ts110 moloney murine sarcoma virus genomic and messenger RNAs

1986 • 10 citations