Binding of Tat Protein to TAR Region of Human Immunodeficiency Virus Type 1 Blocks TAR-Mediated Activation of (2′-5′)Oligoadenylate Synthetase

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Cellular uptake of the tat protein from human immunodeficiency virus

1988 • 2,690 citations

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

1982 • 1,371 citations

Trans -Activator Gene of Human T-Lymphotropic Virus Type III (HTLV-III)

1985 • 872 citations

The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat

1985 • 825 citations

Phosphorylation of initiation factor eIF-2 and the control of reticulocyte protein synthesis

1977 • 750 citations

Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism

1986 • 730 citations

HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA

1986 • 673 citations

Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator protein

1987 • 672 citations

The trans-activator gene of the human T cell lymphotropic virus type III is required for replication

1986 • 615 citations

HIV-1 tat trans-activation requires the loop sequence within tar

1988 • 551 citations

Long-Term Cultures of HTLV-III—Infected T Cells: a Model of Cytopathology of T-Cell Depletion in AIDS

1986 • 537 citations

Trans -Acting Transcriptional Regulation of Human T-Cell Leukemia Virus Type III Long Terminal Repeat

1985 • 500 citations

Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro.

1989 • 472 citations

Tat Protein from Human Immunodeficiency Virus Forms a Metal-Linked Dimer

1988 • 464 citations

Interferon Action: RNA Cleavage Pattern of a (2′-5′)Oligoadenylate—Dependent Endonuclease

1981 • 357 citations

Post-transcriptional regulation accounts for the trans-activation of the human T-lymphotropic virus type III

1986 • 325 citations

Interferon action—sequence specificity of the ppp(A2′p)nA-dependent ribonuclease

1981 • 321 citations

RECOMBINANT HUMAN INTERFERON ALFA-A SUPPRESSES HTLV-III REPLICATION IN VITRO

1985 • 306 citations

Elevated levels of mRNA can account for the trans-activation of human immunodeficiency virus.

1986 • 303 citations

Human immunodeficiency virus long terminal repeat responds to T-cell activation signals.

1987 • 292 citations

Expression and Characterization of the Trans -Activator of HTLV-III/LAV Virus

1986 • 276 citations

A discrete element 3' of human immunodeficiency virus 1 (HIV-1) and HIV-2 mRNA initiation sites mediates transcriptional activation by an HIV trans activator.

1988 • 270 citations

Trans-activation of human immunodeficiency virus gene expression is mediated by nuclear events.

1987 • 246 citations

Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: A novel translational control mechanism

1989 • 196 citations

An interferon-induced phosphodiesterase degrading (2'-5') oligoisoadenylate and the C-C-A terminus of tRNA.

1979 • 183 citations

Demonstration of virus-specific transcriptional activator(s) in cells infected with HTLV-III by an in vitro cell-free system

1986 • 170 citations

Mutational analysis of the 5′ non-coding region of human immunodeficiency virus type 1: effects of secondary structure on translation.

1988 • 168 citations

Mechanism for discrimination between viral and host mRNA in interferon-treated cells.

1979 • 163 citations

Transcriptional but not translational regulation of HIV-1 by the tat gene product

1988 • 158 citations

Activation of interferon-regulated, dsRNA-dependent enzymes by human immunodeficiency virus-1 leader RNA

1989 • 135 citations

Bioassay for trans-activation using purified human immunodeficiency virus tat-encoded protein: trans-activation requires mRNA synthesis.

1989 • 132 citations

Specific binding of a HeLa cell nuclear protein to RNA sequences in the human immunodeficiency virus transactivating region.

1989 • 121 citations

Synthesis of (2'-5')oligoadenylate and activation of an endoribonuclease in interferon-treated HeLa cells infected with reovirus

1982 • 118 citations

Interferon action: Two (2′-5′) (A)n synthetases specified by distinct mRNAs in Ehrlich ascites tumor cells treated with interferon

1983 • 118 citations

CLINICAL, IMMUNOLOGICAL, AND VIROLOGICAL EFFECTS OF AMPLIGEN, A MISMATCHED DOUBLE-STRANDED RNA, IN PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX

1987 • 114 citations

Synthesis of the complete trans-activation gene product of human T-lymphotropic virus type III in Escherichia coli: demonstration of immunogenicity in vivo and expression in vitro.

1986 • 90 citations

Mechanism of Interferon Action: Progress toward Its Understanding

1982 • 84 citations

Antiviral activity of mismatched double-stranded RNA against human immunodeficiency virus in vitro.

1987 • 84 citations

Modulation of Nuclear Matrix-associated 2′,5′-Oligoadenylate Metabolism and Ribonuclease L Activity in H9 Cells by Human Immunodeficiency Virus

1989 • 82 citations

Purification and characterization of a poly(A)-specific exoribonuclease from calf thymus.

1980 • 71 citations

2′5′ Obgoadenylate synthetase, an interferon induced enzyme: direct assay methods for the products, 2′5′ ohgoadenylates and 2′5′ co-oligonucleotides

1980 • 63 citations

Functional characterization of Tat protein from human immunodeficiency virus. Evidence that Tat links viral RNAs to nuclear matrix.

1990 • 61 citations

Physicochemical and functional characterization of the polymerization process of the Geodia cydonium lectin

2008 • 46 citations

An improved method for purifying 2‘,5‘-oligoadenylate synthetases.

1984 • 44 citations

High levels of heterodisperse RNAs accumulate in T cells infected with human immunodeficiency virus and in normal thymocytes.

1988 • 44 citations

Identification and further characterization of the specific cell binding fragment from sponge aggregation factor.

1986 • 42 citations

Alteration of Nuclear (2´-5´) Oligoriboadenylate Synthetase and Nuclease Activities Preceding Replication of Human Immunodeficiency Virus in H9 Cells

1988 • 28 citations

Association of Tat protein and viral mRNA with nuclear matrix from HIV-1-infected H9 cells

1989 • 21 citations