Influenza virus regulates protein synthesis during infection by repressing autophosphorylation and activity of the cellular 68,000-Mr protein kinase

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Biochemistry of Interferons and Their Actions

1982 • 868 citations

Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection

1982 • 395 citations

Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2α kinase

1986 • 358 citations

Interferon, double-stranded RNA, and protein phosphorylation.

1976 • 328 citations

Autophosphorylation of the protein kinase dependent on double-stranded RNA.

1987 • 301 citations

Heat shock-induced translational alterations in HeLa cells. Initiation factor modifications and the inhibition of translation.

1984 • 282 citations

The Regulation of Initiation of Mammalian Protein Synthesis

1981 • 266 citations

Mechanism of interferon action: Phosphorylation of protein synthesis initiation factor eIF-2 in interferon-treated human cells by a ribosome-associated kinase processing site specificity similar to hemin-regulated rabbit reticulocyte kinase

1979 • 263 citations

Structural requirements of double-stranded RNA for the activation of 2‘,5‘-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells.

1979 • 263 citations

Phosphorylation of eukaryotic initiation factor 2 during physiological stresses which affect protein synthesis.

1987 • 257 citations

A mechanism for the control of protein synthesis by adenovirus VA RNAI

1986 • 256 citations

Purification of the eukaryotic initiation factor 2-eukaryotic initiation factor 2B complex and characterization of its guanine nucleotide exchange activity during protein synthesis initiation.

1983 • 203 citations

Adenovirus VAI RNA complexes with the 68 000 Mr protein kinase to regulate its autophosphorylation and activity.

1987 • 181 citations

A GDP/GTP exchange factor essential for eukaryotic initiation factor 2 cycling in Ehrlich ascites tumor cells and its regulation by eukaryotic initiation factor 2 phosphorylation.

1983 • 177 citations

Regulation of Protein Synthesis in Virus-Infected Animal Cells

1986 • 177 citations

2B or not 2B: Regulation of the catalytic utilization of elF-2

1983 • 172 citations

Inhibition of influenza viral mRNA synthesis in cells expressing the interferon-induced Mx gene product

1985 • 159 citations

Regulation of a protein synthesis initiation factor by adenovirus virus-associated RNAI

1985 • 157 citations

Adenovirus VAI RNA prevents phosphorylation of the eukaryotic initiation factor 2 alpha subunit subsequent to infection.

1985 • 155 citations

Regulation of initiation factors during translational repression caused by serum depletion. Covalent modification.

1985 • 153 citations

Hybridization maps of early and late messenger RNA sequences on the adenovirus type 2 genome

1976 • 151 citations

Intracellular Uncoating of Type 5 Adenovirus Deoxyribonucleic Acid

1967 • 141 citations

Monoclonal antibodies to an interferon-induced Mr 68,000 protein and their use for the detection of double-stranded RNA-dependent protein kinase in human cells.

1985 • 138 citations

Translational control by adenovirus: lack of virus-associated RNAI during adenovirus infection results in phosphorylation of initiation factor eIF-2 and inhibition of protein synthesis.

1985 • 117 citations

The double‐stranded RNA‐dependent protein kinase is also activated by heparin

1987 • 116 citations

Characterization of a specific kinase inhibitory factor produced by vaccinia virus which inhibits the interferon-induced protein kinase

1984 • 114 citations

Interferon-mediated, double-stranded RNA-dependent protein kinase is inhibited in extracts from vaccinia virus-infected cells

1984 • 101 citations

Inborn Resistance of Mice to Orthomyxoviruses

1981 • 93 citations

Translational control by influenza virus: suppression of the kinase that phosphorylates the alpha subunit of initiation factor eIF-2 and selective translation of influenza viral mRNAs.

1986 • 92 citations

Cellular mRNA translation is blocked at both initiation and elongation after infection by influenza virus or adenovirus

1986 • 88 citations

Metabolism and expression of RNA polymerase II transcripts in influenza virus-infected cells.

1984 • 80 citations

Two interferon-induced proteins are involved in the protein kinase complex dependent on double-stranded RNA

1985 • 78 citations

Purification of influenza viral complementary RNA: its genetic content and activity in wheat germ cell-free extracts

1975 • 74 citations

Further characterization of the protein kinase activity mediated by interferon in mouse and human cells.

1984 • 60 citations

Regulation of protein synthesis in vesicular stomatitis virus-infected mouse L-929 cells by decreased protein synthesis initiation factor 2 activity

1982 • 51 citations

Rapid decrease in the levels of the double-stranded RNA-dependent protein kinase during virus infections

1987 • 40 citations

Efficient transcription, not translation, is dependent on adenovirus tripartite leader sequences at late times of infection

1988 • 38 citations

Metabolism and Expression of RNA Polymerase II Transcripts in Influenza Virus-Infected Cells

1984 • 38 citations

Translational Control by Influenza Virus: Suppression of the Kinase That Phosphorylates the Alpha Subunit of Initiation Factor eIF-2 and Selective Translation of Influenza Viral mRNAs

1986 • 30 citations

Second phosphorylation site on alpha subunit of eIF-2 in rabbit reticulocyte lysate.

1986 • 1 citations

Deleted Work

1955 • 0 citations