Regulation of gene expression by natural antisense RNA transcripts

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Homeobox genes and axial patterning

1992 • 2,688 citations

The c-erb-A gene encodes a thyroid hormone receptor

1986 • 1,505 citations

Type 1 Neurofibromatosis Gene: Identification of a Large Transcript Disrupted in Three NF1 Patients

1990 • 1,471 citations

RNA editing in brain controls a determinant of ion flow in glutamate-gated channels

1991 • 1,465 citations

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

1983 • 1,407 citations

The Fgf Family of Growth Factors and Oncogenes

1992 • 1,164 citations

Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryo

1987 • 883 citations

A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells

1986 • 834 citations

Transposition and amplification of oncogene-related sequences in human neuroblastomas

1983 • 711 citations

An unwinding activity that covalently modifies its double-stranded RNA substrate

1988 • 702 citations

RNA editing of AMPA receptor subunit GluR-B: A base-paired intron-exon structure determines position and efficiency

1993 • 657 citations

L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer

1985 • 652 citations

Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation

1989 • 612 citations

Antisense Research and Applications

1993 • 604 citations

Expression and Regulation by Interferon of a Double-Stranded-RNA-Specific Adenosine Deaminase from Human Cells: Evidence for Two Forms of the Deaminase

1995 • 534 citations

Identification of a tHyroid Hormone Receptor That Is Pituitary-Specific

1989 • 493 citations

Interactions between double-stranded RNA regulators and the protein kinase DAI.

1992 • 475 citations

Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20.

1993 • 469 citations

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

1989 • 459 citations

ANTISENSE RNA CONTROL IN BACTERIA, PHAGES, AND PLASMIDS

1994 • 440 citations

A developmentally regulated activity that unwinds RNA duplexes

1987 • 439 citations

Deregulation of a Homeobox Gene, HOX11, by the t(10;14) in T Cell Leukemia

1991 • 411 citations

ATP-dependent unwinding of messenger RNA structure by eukaryotic initiation factors.

1985 • 404 citations

Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility

1995 • 390 citations

The Presence of Fibroblast Growth Factor in the Frog Egg: Its Role as a Natural Mesoderm Inducer

1988 • 367 citations

Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat.

1986 • 353 citations

Molecular characterization of the human excision repair gene : cDNA cloning and amino acid homology with the yeast DNA repair gene

1986 • 330 citations

Intragenic pausing and anti-sense transcription within the murine c-myc locus.

1986 • 326 citations

Antisense RNA injections in fertilized frog eggs reveal an RNA duplex unwinding activity

1987 • 320 citations

Homeobox gene expression correlated with the bifurcation process of limb cartilage development

1991 • 317 citations

A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit.

1989 • 316 citations

RNA helicase activity associated with the human p68 protein

1989 • 307 citations

An antisense mRNA directs the covalent modification of the transcript encoding fibroblast growth factor in Xenopus oocytes

1989 • 305 citations

Functional domains of the Drosophila Engrailed protein.

1993 • 280 citations

Homeotic transformations and limb defects in Hox A11 mutant mice.

1993 • 260 citations

ANTISENSE RNA

1991 • 256 citations

Gene within a gene: Nested Drosophila genes encode unrelated proteins on opposite DNA strands

1986 • 251 citations

Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus

1989 • 251 citations

Specificity of antisense oligonucleotides in vivo.

1992 • 248 citations

Isolation and characterization of rat cDNA clones for two distinct thyroid hormone receptors.

1988 • 237 citations

67th ANNUAL MEETING OF THE ENDOCRINE SOCIETY

1985 • 233 citations

Rev is necessary for translation but not cytoplasmic accumulation of HIV-1 vif, vpr, and env/vpu 2 RNAs.

1991 • 232 citations

Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis

1993 • 229 citations

Polyamines Differentially Modulate the Transcription of Growth-associated Genes in Human Colon Carcinoma Cells

1989 • 211 citations

Base pairing of RNA I with its complementary sequence in the primer precursor inhibits ColE1 replication

1981 • 204 citations

The Orphan Receptor Rev-ErbAα Activates Transcription via a Novel Response element

1993 • 199 citations

Two Mammalian Genes Transcribed from Opposite Strands of the Same DNA Locus

1987 • 195 citations

Insulin-like growth factor II in human adrenal pheochromocytomas and Wilms tumors: expression at the mRNA and protein level.

1987 • 191 citations

A mouse locus at which transcription from both DNA strands produces mRNAs complementary at their 3′ ends

1986 • 187 citations

pT181 plasmid replication is regulated by a countertranscript-driven transcriptional attenuator

1989 • 186 citations

Inhibition of c-erbA mRNA splicing by a naturally occurring antisense RNA.

1991 • 184 citations

A transcribed gene in an intron of the human factor VIII gene

1990 • 182 citations

Trans splicing of mrna precursors in vitro

1985 • 180 citations

N-myc mRNA Forms an RNA-RNA Duplex with Endogenous Antisense Transcripts

1990 • 173 citations

Identification and characterization of intragenic sequences which repress human immunodeficiency virus structural gene expression

1991 • 160 citations

Multiple transcription start sites, DNase I-hypersensitive sites, and an opposite-strand exon in the 5' region of the CHO dhfr gene.

1986 • 157 citations

What makes an mRNA anti-sensi-itive?

1993 • 150 citations

Distribution of FGF‐2 suggests it has a role in chick limb bud growth

1993 • 144 citations

The gene structure of the insulin-like growth factor family

1989 • 143 citations

Renaturation of complementary DNA strands mediated by purified mammalian heterogeneous nuclear ribonucleoprotein A1 protein: implications for a mechanism for rapid molecular assembly.

1990 • 139 citations

Alpha 1(IV) and alpha 2(IV) collagen genes are regulated by a bidirectional promoter and a shared enhancer.

1988 • 139 citations

Evolution of Insulin-Like Growth Factor II: Characterization of the Mouse IGF-II Gene and Identification of Two Pseudo-Exons

1990 • 131 citations

The human myc gene family: structure and activity of L-myc and an L-myc pseudogene.

1987 • 130 citations

N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts.

1990 • 129 citations

Dual bidirectional promoters at the mouse dhfr locus: cloning and characterization of two mRNA classes of the divergently transcribed Rep-1 gene.

1989 • 128 citations

Multiple mechanisms for transcriptional regulation of the myc gene family in small-cell lung cancer.

1988 • 127 citations

Antisense oligodeoxynucleotide phosphorothioate complementary to Gag mRNA blocks replication of human immunodeficiency virus type 1 in human peripheral blood cells.

1994 • 120 citations

The orphan receptor Rev-ErbA alpha activates transcription via a novel response element.

1993 • 117 citations

Regulation of the expression of the cell‐cycle gene ftsZ by DicF antisense RNA. Division does not require a fixed number of FtsZ molecules

1992 • 116 citations

A highly conserved sequence motif defining the family of MutT-related proteins from eubacteria, eukaryotes and viruses

1993 • 114 citations

OOP RNA, produced from multicopy plasmids, inhibits lambda cII gene expression through an RNase III-dependent mechanism.

1987 • 111 citations

Characterization of a Third Human Thyroid Hormone Receptor Coexpressed with Other Thyroid Hormone Receptors in Several Tissues

1988 • 110 citations

Human Immunodeficiency Virus May Encode a Novel Protein on the Genomic DNA Plus Strand

1988 • 102 citations

The Rat Gonadotropin-Releasing Hormone: SH Locus: Structure and Hypothalamic Expression

1989 • 101 citations

Editing of α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor GluR-B Pre-mRNA in Vitro Reveals Site-selective Adenosine to Inosine Conversion

1995 • 98 citations

At least two genes reside within a large intron of the dunce gene of Drosophila

1987 • 96 citations

Effect of polyamine depletion on c-myc expression in human colon carcinoma cells.

1988 • 92 citations

Negative-strand RNA transcripts are produced in human immunodeficiency virus type 1-infected cells and patients by a novel promoter downregulated by Tat

1994 • 91 citations

Temporal, differential and regional expression of mRNA for basic fibroblast growth factor in the developing and adult rat brain

1991 • 90 citations

A natural antisense RNA derived from the HIV-1 env gene encodes a protein which is recognized by circulating antibodies of HIV+ individuals

1995 • 80 citations

Expression of Alternatively Spliced bFGF First Coding Exons and Antisense mRNAs during Chicken Embryogenesis

1993 • 80 citations

Bulged-out nucleotides in an antisense RNA are required for rapid target RNA bindingin vitroand inhibitionin vivo

1995 • 80 citations

An antisense transcript from the Xenopus laevis bFGF gene coding for an evolutionarily conserved 24 kd protein.

1989 • 79 citations

Sense and antisense TGFβ3 mRNA levels correlate with cardiac valve induction

1992 • 78 citations

FGF‐2 mRNA and its antisense message are expressed in a developmentally specific manner in the chick limb bud and mesonephros

1995 • 75 citations

TGF‐β3‐Mediated tissue interaction during embryonic heart development

1992 • 74 citations

Antisense overlapping open reading frames in genes from bacteria to humans

1994 • 72 citations

Genomic characterization of the human DNA excision repair geneERCC-1

1987 • 71 citations

Independent regulation of transcription of the two strands of the c-myc gene.

1987 • 63 citations

Basic Fibroblast Growth Factor Sense (FGF) and Antisense (GFG) RNA Transcripts Are Expressed in Unfertilized Human Oocytes and in Differentiated Adult Tissues

1994 • 62 citations

Relative abundance and molecular size of immunoreactive insulin-like growth factors I and II in human fetal tissues

1990 • 61 citations

Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc.

1992 • 55 citations

Cellular response to double-stranded RNA

1991 • 54 citations

Fibroblast Growth Factor Messenger Ribonucleic Acid Expression in a Human Astrocytoma Cell Line: Regulation by Serum and Cell Density

1988 • 54 citations

Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene.

1994 • 54 citations

tcRNA as a naturally occurring antisense RNA in eukaryotes

1986 • 53 citations

The cytoplasm of Xenopus oocytes contains a factor that protects double-stranded RNA from adenosine-to-inosine modification.

1994 • 51 citations

Antisense RNA mediates transcriptional processing in an archaebacterium, indicating a novel kind of RNase activity

1993 • 51 citations

Coordinate gene expression of luteinizing hormone-releasing hormone (LHRH) and the LHRH-receptor after prolactin stimulation in the rat Nb2 T-cell line: implications for a role in immunomodulation and cell cycle gene expression.

1995 • 50 citations

Mechanism of Action of Antisense RNA. Sometime Inhibition of Transcription, Processing, Transport, or Translationa

1992 • 49 citations

Post-transcriptional events are responsible for low expression of myelin basic protein in myelin deficient mice: role of natural antisense RNA.

1990 • 49 citations

Nuclear β-decay and the origin of biomolecular chirality

1987 • 49 citations

Expression of the rat BFGF antisense RNA transcript is tissue-specific and developmentally regulated

1996 • 47 citations

Identification of antisense transcripts of the chicken insulin-like growth factor-II gene

1991 • 46 citations

Processing of gonadotropin-releasing hormone gene transcripts in the rat brain.

1994 • 46 citations

Double-stranded RNA adenosine deaminase as a potential mammalian RNA editing factor

1993 • 46 citations

Gonadotropin-Releasing Hormone and Chorionic Gonadotropin Gene Expression in Human Placental Development

1991 • 45 citations

Characterization of an endogenous RNA transcript with homology to the antisense strand of the human c-myc gene.

1992 • 43 citations

Conserved pattern of antisense overlapping transcription in the homologous human ERCC-1 and yeast RAD10 DNA repair gene regions.

1989 • 42 citations

The Basic Fibroblast Growth Factor (FGF-2) Antisense RNA (GFG) Is Translated into a MutT-Related Proteinin Vivo

1996 • 40 citations

Mechanisms of Cell Transformation in the Embryonic Heart^a

1995 • 36 citations

The FGF6 Gene within the FGF Multigene Familya

1991 • 36 citations

Two N-myc polypeptides with distinct amino termini encoded by the second and third exons of the gene.

1989 • 30 citations

A possible role for the pcnB gene product of Escherichia coli in modulating RNA:RNA interactions

1990 • 28 citations

Identification of an antisense transcript from the IGF‐II locus in mouse

1993 • 27 citations

Coordinate gene expression of luteinizing hormone-releasing hormone (LHRH) and the LHRH-receptor after prolactin stimulation in the rat Nb2 T-cell line: implications for a role in immunomodulation and cell cycle gene expression

1995 • 27 citations

Messenger RNA Stabilization Accounts for Elevated Basic Fibroblast Growth Factor Transcript Levels in a Human Astrocytoma Cell Line

1990 • 26 citations

Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene

1994 • 25 citations

Detection of anti-sense transcripts of the insulin-like growth factor-2 gene in Wilms' tumor.

1993 • 24 citations

Structural alteration of the insulin-like growth factor II-gene in Wilms tumour

1989 • 23 citations

Analysis of theHoxd-3Gene: Structure and Localization of Its Sense and Natural Antisense Transcripts

1995 • 21 citations

Sequences in the rev‐responsive element responible for premature translational arrest in the human‐immunodeficiency‐virus‐type‐1 envelope

1993 • 9 citations