Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

A new method for sequencing DNA.

1977 • 7,941 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

INTERFERONS AND THEIR ACTIONS

1987 • 1,838 citations

Purification and Biochemical Characterization of the Promoter-Specific Transcription Factor, Sp1

1986 • 1,473 citations

Affinity purification of sequence-specific DNA binding proteins.

1986 • 1,255 citations

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

1988 • 984 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

Synthetic oligonucleotide probes deduced from amino acid sequence data

1985 • 759 citations

Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells

1984 • 729 citations

Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control.

1988 • 583 citations

α-Interferon-induced transcription of HLA and metallothionein genes containing homologous upstream sequences

1985 • 498 citations

The involvement of NF-κB in β-interferon gene regulation reveals its role as widely inducible mediator of signal transduction

1989 • 494 citations

Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro.

1989 • 484 citations

Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element.

1987 • 398 citations

Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1

1989 • 368 citations

Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-beta gene regulatory elements.

1988 • 342 citations

Double-stranded RNA activates binding of NF-kappa B to an inducible element in the human beta-interferon promoter.

1989 • 317 citations

Interferon response element of the human gene 6-16.

1988 • 292 citations

A single DNA response element can confer inducibility by both alpha- and gamma-interferons.

1989 • 262 citations

Overlapping positive and negative regulatory domains of the human beta-interferon gene.

1988 • 237 citations

The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse kappa immunoglobulin J and C region genes.

1981 • 236 citations

Transcriptional induction of two genes in human cells by beta interferon.

1984 • 236 citations

Interferon-β gene regulation: Tandemly repeated sequences of a synthetic 6 bp oligomer function as a virus-inducible enhancer

1987 • 233 citations

Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes.

1988 • 228 citations

Organization of the Murine Mx Gene and Characterization of Its Interferon- and Virus-Inducible Promoter

1988 • 206 citations

Transcriptional induction by interferon. New protein(s) determine the extent and length of the induction.

1986 • 204 citations

Interferon-induced binding of nuclear factors to promoter elements of the 2-5A synthetase gene.

1988 • 190 citations

Enhancer-like interferon responsive sequences of the human and murine (2′-5′) oligoadenylate synthetase gene promoters.

1988 • 188 citations

Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region.

1986 • 185 citations

Two different virus-inducible elements are required for human beta-interferon gene regulation.

1989 • 168 citations

Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein.

1989 • 159 citations

Molecular characterization of the interferon-induced 15-kDa protein. Molecular cloning and nucleotide and amino acid sequence.

1986 • 151 citations

The adenovirus-inducible factor E2F stimulates transcription after specific DNA binding.

1989 • 137 citations

Induction of human interferon gene expression is associated with a nuclear factor that interacts with the NF-kappa B site of the human immunodeficiency virus enhancer

1989 • 135 citations

Overlapping sites for constitutive and induced DNA binding factors involved in interferon-stimulated transcription.

1989 • 134 citations

Transcription of interferon-stimulated genes is induced by adenovirus particles but is suppressed by E1A gene products

1988 • 124 citations

Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter.

1988 • 124 citations

Involvement of acis-element that binds an H2TF-l/NFxB like factor(s) in the virus-induced interferon-β gene expression

1989 • 118 citations

A gamma-interferon-induced factor that binds the interferon response sequence of the MHC class I gene, H-2Kb.

1989 • 113 citations

New inducers revealed by the promoter sequence analysis of two interferon-activated human genes

1987 • 110 citations

Coordinate viral induction of tumor necrosis factor alpha and interferon beta in human B cells and monocytes.

1989 • 108 citations

Identification of an inducible factor that binds to a positive regulatory element of the human beta-interferon gene.

1988 • 106 citations

Phorbol-ester-induced Activation of the NF- B Transcription Factor Involves Dissociation of an Apparently Cytoplasmic NF- B/Inhibitor Complex

1988 • 94 citations

Interferons And Their Actions

1987 • 91 citations

Cells resistant to interferon are defective in activation of a promoter-binding factor.

1988 • 83 citations

Differential binding of interferon-induced factors to an oligonucleotide that mediates transcriptional activation

1989 • 76 citations

Sequence of a cDNA coding for human IRF-1

1989 • 74 citations

The Adenovirus-Inducible Factor E2F Stimulates Transcription after Specific DNA Binding

1989 • 52 citations

Transcriptional stimulation by CaPO₄-DNA precipitates

1988 • 49 citations

Virus Infection and Interferon can Activate Gene Expression Through a Single Synthetic Element, but Endogenous Genes Show Distinct Regulation

1989 • 40 citations

Enhancer functions andin vitroprotein binding of native and mutated interferon-responsive sequences

1989 • 30 citations

Interferons alpha and beta as cellular regulatory molecules.

1987 • 28 citations

Transcriptional Regulation of Interferon-stimulated Genes: A DNA Response Element and Induced Proteins That Recognize It

1988 • 25 citations

Notes: In Vivo Evidence of Interaction between Interferon-Stimulated Gene Factors and the Interferon-Stimulated Response Element

1989 • 16 citations

In vivo evidence of interaction between interferon-stimulated gene factors and the interferon-stimulated response element.

1989 • 11 citations

Deleted Work

1955 • 0 citations