Two RNA-binding motifs in the double-stranded RNA-activated protein kinase, DAI.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Antibodies, a laboratory manual

1989 • 12,929 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

Prediction of protein conformation

1974 • 3,327 citations

Affinity purification of sequence-specific DNA binding proteins.

1986 • 1,255 citations

Efficient Translation of Tobacco Mosaic Virus RNA and Rabbit Globin 9S RNA in a Cell-Free System from Commercial Wheat Germ

1973 • 1,213 citations

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1990 • 1,003 citations

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method.

1988 • 983 citations

Structure of E. coli Glutaminyl-tRNA Synthetase Complexed with tRNA ^Gln and ATP at 2.8 Å Resolution

1989 • 888 citations

Phosphorylation of initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

1992 • 768 citations

Phosphorylation of initiation factor eIF-2 and the control of reticulocyte protein synthesis

1977 • 750 citations

RNA recognition: towards identifying determinants of specificity

1991 • 739 citations

Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities

1991 • 600 citations

EUKARYOTIC PROTEIN SYNTHESIS

1985 • 538 citations

Structural studies of protein–nucleic acid interaction: the sources of sequence-specific binding

1990 • 508 citations

Interactions between double-stranded RNA regulators and the protein kinase DAI.

1992 • 475 citations

Sequence-specific recognition of RNA hairpins by bacteriophage antiterminators requires a conserved arginine-rich motif

1989 • 395 citations

Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2α kinase

1986 • 358 citations

Interferon, double-stranded RNA, and protein phosphorylation.

1976 • 328 citations

Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2.

1992 • 325 citations

Protein Phosphorylation Controls Translation Rates

1989 • 303 citations

Autophosphorylation of the protein kinase dependent on double-stranded RNA.

1987 • 301 citations

Mutations at a Zn(II) finger motif in the yeast elF-2β gene alter ribosomal start-site selection during the scanning process

1988 • 283 citations

Structural requirements of double-stranded RNA for the activation of 2‘,5‘-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells.

1979 • 263 citations

A mechanism for the control of protein synthesis by adenovirus VA RNAI

1986 • 256 citations

The characteristics of inhibition of protein synthesis by double-stranded ribonucleic acid in reticulocyte lysates

1975 • 254 citations

Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system.

1991 • 207 citations

Regulation of protein synthesis: Activation by double-stranded RNA of a protein kinase that phosphorylates eukaryotic initiation factor 2

1978 • 206 citations

Purification of the eukaryotic initiation factor 2-eukaryotic initiation factor 2B complex and characterization of its guanine nucleotide exchange activity during protein synthesis initiation.

1983 • 203 citations

The Double Stranded RNA-Activated Protein Kinase Induced by Interferon: dsRNA-PK

1989 • 202 citations

Yeast translation initiation suppressor sui2 encodes the alpha subunit of eukaryotic initiation factor 2 and shares sequence identity with the human alpha subunit.

1989 • 201 citations

Purification and activation of the double-stranded RNA-dependent eIF-2 kinase DAI.

1989 • 197 citations

A GDP/GTP exchange factor essential for eukaryotic initiation factor 2 cycling in Ehrlich ascites tumor cells and its regulation by eukaryotic initiation factor 2 phosphorylation.

1983 • 177 citations

Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase.

1992 • 176 citations

Mechanism of interferon action: Identification of a RNA binding domain within the N-terminal region of the human RNA-dependent P1/eIF-2α protein kinase

1992 • 170 citations

The binding of double-stranded RNA and adenovirus VAI RNA to the interferon-induced protein kinase

1989 • 143 citations

Structure and regulation of eukaryotic initiation factor eIF-2. Sequence of the site in the alpha subunit phosphorylated by the haem-controlled repressor and by the double-stranded RNA-activated inhibitor

1987 • 129 citations

Guanine nucleotides, protein phosphorylation and the control of translation

1986 • 124 citations

Identification of the double-stranded RNA-binding domain of the human interferon-inducible protein kinase.

1992 • 121 citations

Involvement of an initiation factor and protein phosphorylation in translational control of GCN4 mRNA

1990 • 117 citations

Mechanism of interferon action: cDNA structure, expression, and regulation of the interferon-induced, RNA-dependent P1/eIF-2α protein kinase from human cells

1992 • 116 citations

Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression.

1990 • 115 citations

Growth-related expression of a double-stranded RNA-dependent protein kinase in 3T3 cells.

1984 • 91 citations

Mechanism of interferon action. Purification and substrate specificities of the double-stranded RNA-dependent protein kinase from untreated and interferon-treated mouse fibroblasts.

1985 • 78 citations

Effects of mutations in stem and loop regions on the structure and function of adenovirus VA RNAI.

1988 • 78 citations

Removal of double-stranded contaminants from RNA transcripts: synthesis of adenovirus VA RNA₁from a T7 vector

1990 • 65 citations

Binding of the adenovirus VAI RNA to the interferon-induced 68-kDa protein kinase correlates with function.

1991 • 61 citations

Inhibition of protein synthesis by double-stranded RNA and phosphorylation of initiation factor, eIF-2.

1978 • 55 citations

Functional dissection of adenovirus VAI RNA

1989 • 54 citations

Initiation of protein synthesis

1976 • 50 citations

Activation of 2',5'-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells by 2'-O-methylated poly (inosinic acid) . poly(cytidylic acid), Correlations with interferon-inducing activity.

1980 • 47 citations

Partial characterization of a cellular factor that regulates the double-stranded RNA-dependent eIF-2 alpha kinase in 3T3-F442A fibroblasts.

1991 • 46 citations

Reduced Activity of the Interferon-induced Double-stranded RNA-dependent Protein Kinase during a Heat Shock Stress

1989 • 35 citations