Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome

Experiments in molecular genetics

1972 • 28,260 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Regulation of Inducible and Tissue-Specific Gene Expression

1987 • 1,640 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

1988 • 984 citations

Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.

1988 • 897 citations

Transcriptional regulation

1991 • 893 citations

The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures

1992 • 684 citations

Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

1993 • 638 citations

The High Mobility Group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene

1992 • 632 citations

Genetic Switch

2008 • 590 citations

Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions.

1995 • 546 citations

Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements

1993 • 440 citations

A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives

1990 • 386 citations

Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated

1990 • 377 citations

Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-beta gene regulatory elements.

1988 • 342 citations

Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter

1986 • 336 citations

Promoters responsive to DNA bending: a common theme in prokaryotic gene expression

1994 • 322 citations

Endothelial Interferon Regulatory Factor 1 Cooperates with NF-κB as a Transcriptional Activator of Vascular Cell Adhesion Molecule 1

1995 • 301 citations

Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements

1995 • 300 citations

Transcriptional activation and repression by Ultrabithorax proteins in cultured Drosophila cells

1989 • 291 citations

The SV40 enhancer contains two distinct levels of organization

1988 • 286 citations

Human β-interferon gene expression is regulated by an inducible enhancer element

1985 • 283 citations

Reversal of intrinsic DNA bends in the IFNβ gene enhancer by transcription factors and the architectural protein HMG I(Y)

1995 • 280 citations

Early and late periodic patterns of even skipped expression are controlled by distinct regulatory elements that respond to different spatial cues

1989 • 273 citations

Functional relationships between transcriptional control signals of the thymidine kinase gene of herpes simplex virus

1982 • 253 citations

Cooperativity and hierarchical levels of functional organization in the SV40 enhancer

1988 • 238 citations

DNA bending and orientation-dependent function of YY1 in the c-fos promoter.

1993 • 233 citations

Short-Range DNA Looping by the Xenopus HMG-Box Transcription Factor, xUBF

1994 • 216 citations

Cyclic AMP-independent ATF family members interact with NF-kappa B and function in the activation of the E-selectin promoter in response to cytokines.

1993 • 191 citations

A Striking Similarity in the Organization of the E-Selectin and Bate Interferon gene Promoters

1994 • 187 citations

Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes.

1994 • 186 citations

Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y.

1994 • 176 citations

Two different virus-inducible elements are required for human beta-interferon gene regulation.

1989 • 168 citations

Higher-order nucleoprotein complexes in transcription: analogies with site-specific recombination

1995 • 164 citations

LEF-1 contains an activation domain that stimulates transcription only in a specific context of factor-binding sites.

1993 • 161 citations

Cooperativity between two NF-kappa B complexes, mediated by high-mobility-group protein I(Y), is essential for cytokine-induced expression of the E-selectin promoter.

1994 • 159 citations

Identification of the rel Family Members Required for Virus Induction of the Human Beta Interferon Gene

1995 • 142 citations

A Drosophila CREB/ATF transcriptional activator binds to both fat body- and liver-specific regulatory elements.

1992 • 120 citations

A striking similarity in the organization of the E-selectin and beta interferon gene promoters.

1994 • 117 citations

Promoters responsive to DNA bending: a common theme in prokaryotic gene expression.

1994 • 99 citations

The high mobility group protein HMG I(Y) can stimulate or inhibit DNA binding of distinct transcription factor ATF-2 isoforms.

1994 • 88 citations

Viral induction of the human beta interferon promoter: modulation of transcription by NF-kappa B/rel proteins and interferon regulatory factors

1994 • 86 citations

Synergism between distinct enhanson domains in viral induction of the human beta interferon gene.

1990 • 82 citations

The High Mobility Group Protein HMG I(Y) Is an Essential Structural Component of a Virus-inducible Enhancer Complex

1993 • 73 citations

Constraints on spacing between transcription factor binding sites in a simple adenovirus promoter.

1988 • 62 citations

Multiple modes of dorsal-bHLH transcriptional synergy in the Drosophila embryo.

1995 • 60 citations

Identification of cis-regulatory elements required for larval expression of the Drosophila melanogaster alcohol dehydrogenase gene.

1990 • 51 citations

Two distant and precisely positioned domains promote transcription of Xenopus laevis rRNA genes: analysis with linker-scanning mutants.

1986 • 47 citations

Related Target Enhancers for Dorsal and NF-κB Signaling Pathways

1994 • 37 citations

Transcription factor-induced, phased bending of the E-selectin promoter.

1994 • 31 citations

Domains of the rat rDNA promoter must be aligned stereospecifically.

1992 • 30 citations