S338 Phosphorylation of Raf-1 Is Independent of Phosphatidylinositol 3-Kinase and Pak3

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Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)

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Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

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1994 • 476 citations

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

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Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras

1997 • 451 citations

Differential Regulation of Raf-1, A-Raf, and B-Raf by Oncogenic Ras and Tyrosine Kinases

1997 • 446 citations

Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

1998 • 437 citations

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

1998 • 435 citations

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PAK to the future

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1996 • 372 citations

Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase.

1993 • 345 citations

All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral

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Identification of the major phosphorylation sites of the Raf-1 kinase

1993 • 337 citations

Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization

1996 • 310 citations

Role of Phosphoinositide 3-Kinase in Activation of Ras and Mitogen-Activated Protein Kinase by Epidermal Growth Factor

1999 • 280 citations

p21-Activated protein kinase: a crucial component of morphological signaling?

1999 • 261 citations

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck

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Isotype-Specific Functions of Raf Kinases

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Control of the ERK MAP kinase cascade by Ras and Raf.

1996 • 249 citations

Negative regulation of the serine/threonine kinase B-Raf by Akt

2000 • 249 citations

Oligomerization activates c-Raf-1 through a Ras-dependent mechanism

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Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338

2000 • 225 citations

Negative Regulation of the Serine/Threonine Kinase B-Raf by Akt

2000 • 209 citations

Kinase-Deficient Pak1 Mutants Inhibit Ras Transformation of Rat-1 Fibroblasts

1997 • 199 citations

The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site.

1996 • 198 citations

Conditional Inhibition of the Mitogen-activated Protein Kinase Cascade by Wortmannin

1997 • 196 citations

Phosphorylation of Raf-1 Serine 338-Serine 339 Is an Essential Regulatory Event for Ras-Dependent Activation and Biological Signaling

1997 • 196 citations

The p21Rac/Cdc42-activated kinases (PAKs)

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A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function.

1994 • 185 citations

Regulation of Raf-1 and Raf-1 Mutants by Ras-Dependent and Ras-Independent Mechanisms In Vitro

1995 • 140 citations

Activation of c-Raf-1 by Ras and Src through different mechanisms: activationin vivoandin vitro

1997 • 140 citations

Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak

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A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK

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Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells.

1993 • 98 citations

A role for Pak protein kinases in Schwann cell transformation

1998 • 91 citations

Critical Tyrosine Residues Regulate the Enzymatic and Biological Activity of Raf-1 Kinase

1993 • 84 citations

Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms

1998 • 73 citations