Lysophosphatidic Acid Stimulates p21-Activated Kinase in Vascular Smooth Muscle Cells

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 • 1,473 citations

Signal characteristics of G protein-transactivated EGF receptor

1997 • 669 citations

The bioactive phospholipid lysophosphatidic acid is released from activated platelets

1993 • 653 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Activation of Rac and Cdc42 by Integrins Mediates Cell Spreading

1998 • 638 citations

Role of NADH/NADPH Oxidase–Derived H ₂ O ₂ in Angiotensin II–Induced Vascular Hypertrophy

1998 • 616 citations

Gβγ Subunits Mediate Src-dependent Phosphorylation of the Epidermal Growth Factor Receptor

1997 • 456 citations

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

1998 • 435 citations

Identification of a Mouse p21Cdc42/Rac Activated Kinase

1995 • 395 citations

p21-Activated Kinase 1 (Pak1) Regulates Cell Motility in Mammalian Fibroblasts

1999 • 380 citations

p21-Activated Kinase 1 Phosphorylates the Death Agonist Bad and Protects Cells from Apoptosis

2000 • 356 citations

A Role for P21-Activated Kinase in Endothelial Cell Migration

1999 • 295 citations

Actions of Rho Family Small G Proteins and p21-Activated Protein Kinases on Mitogen-Activated Protein Kinase Family Members

1996 • 275 citations

p21-Activated protein kinase: a crucial component of morphological signaling?

1999 • 261 citations

G Protein-coupled Receptors Mediate Two Functionally Distinct Pathways of Tyrosine Phosphorylation in Rat 1a Fibroblasts

1997 • 233 citations

Lysophosphatidic acid stimulates mitogen-activated protein kinase activation via a G-protein-coupled pathway requiring p21ras and p74raf-1.

1993 • 233 citations

Angiotensin II stimulates the pp44 and pp42 mitogen-activated protein kinases in cultured rat aortic smooth muscle cells

1992 • 210 citations

A GTPase-independent Mechanism of p21-activated Kinase Activation

1998 • 204 citations

Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal.

1992 • 195 citations

Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1

2000 • 176 citations

Participation of Reactive Oxygen Species in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Kinase Activation Pathway

1995 • 176 citations

Angiotensin II Activates pp60 ^{c- src} in Vascular Smooth Muscle Cells

1995 • 167 citations

Activation of Extracellular Signal–Regulated Kinases (ERK1/2) by Angiotensin II Is Dependent on c-Src in Vascular Smooth Muscle Cells

1998 • 162 citations

Role of Tyrosine Kinase Activity of Epidermal Growth Factor Receptor in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Pathway

1998 • 149 citations

Angiotensin II Controls p21 Activity via pp60

1996 • 138 citations

Angiotensin II-induced growth of vascular smooth muscle cells requires an Src-dependent activation of the epidermal growth factor receptor

2000 • 136 citations

Requirement of SHP2 Binding to Grb2-associated Binder-1 for Mitogen-activated Protein Kinase Activation in Response to Lysophosphatidic Acid and Epidermal Growth Factor

2000 • 135 citations

Lysophosphatidic acid prevents apoptosis in fibroblasts via Gi-protein-mediated activation of mitogen-activated protein kinase

2000 • 121 citations

THE PHYSIOLOGICAL RELATION OF PLANT CAROTINOIDS TO THE CAROTINOIDS OF THE COW, HORSE, SHEEP, GOAT, PIG, AND HEN

1916 • 119 citations

Sphingosine-1-Phosphate and Lysophosphatidic Acid Stimulate Endothelial Cell Migration

2000 • 103 citations

Angiotensin II Stimulates p21-Activated Kinase in Vascular Smooth Muscle Cells

1998 • 89 citations

Angiotensin II-induced Stimulation of p21-activated Kinase and c-Jun NH2-terminal Kinase Is Mediated by Rac1 and Nck

2001 • 63 citations

Regulation of Rac and Cdc42 Pathways by Gi during Lysophosphatidic Acid-induced Cell Spreading

2001 • 56 citations

Phosphorylation site specificity of the Pak‐mediated regulation of Raf‐1 and cooperativity with Src

2001 • 48 citations

The platelet-derived-growth-factor receptor, not the epidermal-growth-factor receptor, is used by lysophosphatidic acid to activate p42/44 mitogen-activated protein kinase and to induce prostaglandin G/H synthase-2 in mesangial cells

2000 • 42 citations

Lysophosphatidic acid and intracellular signalling in vascular smooth muscle cells

1997 • 41 citations

Src and Rac Mediate Endothelin-1 and Lysophosphatidic Acid Stimulation of the Human Brain Natriuretic Peptide Promoter

2001 • 35 citations

Angiotensin II Stimulates Tyrosine Phosphorylation of Phospholipase C-γ–Associated Proteins

1997 • 32 citations

The platelet-derived-growth-factor receptor, not the epidermal-growth-factor receptor, is used by lysophosphatidic acid to activate p42/44 mitogen-activated protein kinase and to induce prostaglandin G/H synthase-2 in mesangial cells

2000 • 10 citations