Differing structural requirements for GTPase-activating protein responsiveness and NADPH oxidase activation by Rac.

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2

1991 • 669 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

The superoxide‐generating oxidase of phagocytic cells

1991 • 564 citations

Identification of a Protein that Binds to the SH3 Region of Abl and Is Similar to Bcr and GAP-rho

1992 • 553 citations

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

1988 • 533 citations

Bcr encodes a GTPase-activating protein for p21rac

1991 • 474 citations

Three-dimensional structures of H-ras p21 mutants: Molecular basis for their inability to function as signal switch molecules

1990 • 395 citations

Cytochrome b ₅₅₈ : the Flavin-Binding Component of the Phagocyte NADPH Oxidase

1992 • 384 citations

Association between GTPase activators for Rho and Ras families

1992 • 322 citations

Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components.

1993 • 316 citations

The structure of Ras protein: a model for a universal molecular switch

1991 • 310 citations

Identification of effector residues and a neutralizing epitope of Ha-ras-encoded p21.

1986 • 291 citations

Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity.

1992 • 268 citations

Reconstitution of neutrophil NADPH oxidase activity in the cell-free system by four components: p67-phox, p47-phox, p21rac1, and cytochrome b-245.

1992 • 265 citations

Complexes of polyoma virus medium T antigen and cellular proteins.

1985 • 223 citations

Emerging concepts in the Ras superfamily of GTP‐binding proteins

1993 • 208 citations

The effector interactions of p21ras

1993 • 193 citations

The biochemistry of ras p21

1991 • 176 citations

Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase.

1992 • 176 citations

Requirement for posttranslational processing of Rac GTP-binding proteins for activation of human neutrophil NADPH oxidase.

1993 • 130 citations

Ras-related proteins

1993 • 118 citations

Identification of Small Clusters of Divergent Amino Acids that Mediate the Opposing Effects of ras and K rev -1

1990 • 114 citations

Regulation of NADPH oxidase activity by Rac GTPase activating protein(s).

1993 • 94 citations

Ras interaction with the GTPase‐activating protein (GAP)

1989 • 87 citations

Different structural organization of Ras and Rho effector domains.

1993 • 83 citations

Amino acid residues in the Ras-like GTPase Rab3A that specify sensitivity to factors that regulate the GTP/GDP cycling of Rab3A

1992 • 82 citations

Human ABR encodes a protein with GAPrac activity and homology to the DBL nucleotide exchange factor domain

1993 • 70 citations

Identification of amino acid residues required for Ras p21 target activation.

1991 • 53 citations

The role of small GTP-binding proteins in leukocyte function

1994 • 39 citations

rho GAP of 28 kDa (GAP2), but not of 190 kDa (p190), requires Asp65 and Asp67 of rho GTPase for its activation.

1993 • 21 citations

Biochemical characterization of yeast RAS2 mutants reveals a new region of ras protein involved in the interaction with GTPase-activating proteins.

1994 • 14 citations

Mapping the nucleotide-dependent conformational change of human N-ras p21 in solution by heteronuclear-edited proton-observed NMR methods

1993 • 13 citations