Ligands of Macrophage Scavenger Receptor Induce Cytokine Expression via Differential Modulation of Protein Kinase Signaling Pathways

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

1979 • 2,458 citations

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

1983 • 2,306 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

1994 • 1,426 citations

A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

1997 • 1,210 citations

STRUCTURES AND FUNCTIONS OF MULTILIGAND LIPOPROTEIN RECEPTORS: Macrophage Scavenger Receptors and LDL Receptor-Related Protein (LRP)

1994 • 1,175 citations

Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

1989 • 1,126 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils

1990 • 1,039 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.

1995 • 667 citations

Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme.

1995 • 643 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Recognition and plasma clearance of endotoxin by scavenger receptors

1991 • 529 citations

ATF-2 contains a phosphorylation-dependent transcriptional activation domain.

1995 • 504 citations

A macrophage receptor that recognizes oxidized low density lipoprotein but not acetylated low density lipoprotein

1989 • 480 citations

Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.

1994 • 443 citations

Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro.

1996 • 427 citations

Identification of a Mouse p21Cdc42/Rac Activated Kinase

1995 • 395 citations

Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions.

1990 • 360 citations

Divalent cation-independent macrophage adhesion inhibited by monoclonal antibody to murine scavenger receptor

1993 • 348 citations

THE ROLE OF THEhsp90-BASED CHAPERONE SYSTEM IN SIGNAL TRANSDUCTION BY NUCLEAR RECEPTORS AND RECEPTORS SIGNALING VIA MAP KINASE

1997 • 329 citations

Identification by mass spectrometry of threonine 97 in bovine myelin basic protein as a specific phosphorylation site for mitogen-activated protein kinase.

1990 • 245 citations

Charged collagen structure mediates the recognition of negatively charged macromolecules by macrophage scavenger receptors.

1993 • 243 citations

Molecular Cloning of a New Member of the p21-Cdc42/Rac-activated Kinase (PAK) Family

1995 • 240 citations

The Ras-JNK Pathway Is Involved in Shear-Induced Gene Expression

1996 • 234 citations

p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient

1996 • 217 citations

Human Monocytes/Macrophages Release TNF-α in Response to Ox-LDL

1996 • 211 citations

Production of tumor necrosis factor and interleukin-1 by macrophages from human atheromatous plaques.

1993 • 186 citations

Accelerated Atherosclerosis in Mice Lacking Tumor Necrosis Factor Receptor p55

1996 • 183 citations

Macrophages adhere to glucose-modified basement membrane collagen IV via their scavenger receptors.

1994 • 182 citations

Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90

1999 • 182 citations

Recognition of solubilized apoproteins from delipidated, oxidized low density lipoprotein (LDL) by the acetyl-LDL receptor.

1987 • 171 citations

The MKK6/p38 Stress Kinase Cascade Is Critical for Tumor Necrosis Factor-–Induced Expression of Monocyte-Chemoattractant Protein-1 in Endothelial Cells

1999 • 160 citations

Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin

1997 • 155 citations

Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors

1993 • 155 citations

The collagenous domains of macrophage scavenger receptors and complement component C1q mediate their similar, but not identical, binding specificities for polyanionic ligands.

1993 • 150 citations

A macrophage receptor for oxidized low density lipoprotein distinct from the receptor for acetyl low density lipoprotein: partial purification and role in recognition of oxidatively damaged cells.

1995 • 144 citations

Coexpression of type I and type II human macrophage scavenger receptors in macrophages of various organs and foam cells in atherosclerotic lesions.

1992 • 144 citations

Role of macrophage scavenger receptors in diet-induced atherosclerosis in mice.

1998 • 144 citations

Evaluation of the role of mitogen-activated protein kinases in the expression of inducible nitric oxide synthase by IFN-gamma and TNF-alpha in mouse macrophages.

1999 • 141 citations

Regulation of the interleukin-1 beta (IL-1 beta) gene by mycobacterial components and lipopolysaccharide is mediated by two nuclear factor-IL6 motifs.

1993 • 131 citations

Inhibition of Macrophage Scavenger Receptor Activity by Tumor Necrosis Factor-α Is Transcriptionally and Post-transcriptionally Regulated

1996 • 120 citations

Evaluation of the Role of Mitogen-Activated Protein Kinases in the Expression of Inducible Nitric Oxide Synthase by IFN-γ and TNF-α in Mouse Macrophages

1999 • 119 citations

Tumor Necrosis Factor (TNF) Receptor 1 Signaling Downstream of TNF Receptor-associated Factor 2

1997 • 117 citations

Curcumin inhibits TPA induced expression of c-fos, c-jun and c-myc proto-oncogenes messenger RNAs in mouse skin

1994 • 114 citations

Differential Roles of Extracellular Signal-regulated Kinase-1/2 and p38MAPK in Interleukin-1β- and Tumor Necrosis Factor-α-induced Low Density Lipoprotein Receptor Expression in HepG2 Cells

1998 • 100 citations

Ligand Binding to Macrophage Scavenger Receptor-A Induces Urokinase-type Plasminogen Activator Expression by a Protein Kinase-dependent Signaling Pathway

1998 • 97 citations

Colocalization of CPP-32 With Apoptotic Cells in Human Atherosclerotic Plaques

1997 • 90 citations

Secreted extracellular domains of macrophage scavenger receptors form elongated trimers which specifically bind crocidolite asbestos.

1993 • 83 citations

Regulated expression of the human acetylated low density lipoprotein receptor gene and isolation of promoter sequences.

1992 • 66 citations

The effects of oxidized low density lipoproteins on inducible mouse macrophage gene expression are gene and stimulus dependent.

1995 • 63 citations

Receptors for proteins modified by advanced glycation endproducts (AGE)—their functional role in atherosclerosis

1999 • 62 citations

Induction of interleukin-1 production by ligands binding to the scavenger receptor in human monocytes and the THP-1 cell line.

1991 • 61 citations

Tumor Necrosis Factor-α-mediated Protein Kinases in Regulation of Scavenger Receptor and Foam Cell Formation on Macrophage

2000 • 59 citations

The Processing of Ligands by the Class A Scavenger Receptor Is Dependent on Signal Information Located in the Cytoplasmic Domain

1999 • 50 citations

Stimulation of macrophage urokinase expression by polyanions is protein kinase C-dependent and requires protein and RNA synthesis.

1991 • 42 citations

Acetyl‐LDL stimulates macrophage‐dependent plasminogen activation and degradation of extracellular matrix

1988 • 42 citations

Modulation of macrophage scavenger receptor transport by protein phosphorylation

1996 • 23 citations