Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

1993 • 1,148 citations

A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages.

1996 • 946 citations

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases

1999 • 765 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

1997 • 687 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Inhibition of Myosin Light Chain Kinase by p21-Activated Kinase

1999 • 592 citations

Expression of Constitutively Active α-PAK Reveals Effects of the Kinase on Actin and Focal Complexes

1997 • 560 citations

PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase

1995 • 542 citations

Chemoattractant signaling and leukocyte activation

1995 • 510 citations

Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes

1997 • 445 citations

Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.

1994 • 443 citations

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

1994 • 439 citations

Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages

1997 • 415 citations

Regulation of Human Leukocyte p21-Activated Kinases Through G Protein—Coupled Receptors

1995 • 415 citations

Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42.

1995 • 386 citations

Signal transduction and actin filament organization

1996 • 309 citations

Membrane targeting of p21-activated kinase 1(PAK1) induces neurite outgrowth from PC12 cells

1998 • 296 citations

Rho: theme and variations

1996 • 290 citations

Emerging from the Pak: the p21-activated protein kinase family

1997 • 285 citations

Mechanisms of phagocytosis

1996 • 265 citations

Localization of p21-Activated Kinase 1 (PAK1) to Pinocytic Vesicles and Cortical Actin Structures in Stimulated Cells

1997 • 230 citations

Multivesicular body morphogenesis requires phosphatidyl-inositol 3-kinase activity

1999 • 214 citations

Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling.

1994 • 212 citations

Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophages.

1993 • 201 citations

Signal transduction of phagocytosis

1995 • 190 citations

Rho is Required for the Initiation of Calcium Signaling and Phagocytosis by Fcγ Receptors in Macrophages

1997 • 170 citations

Changes in cytoskeletal proteins of polymorphonuclear leukocytes induced by chemotactic peptides

1983 • 153 citations

Two Signaling Mechanisms for Activation of αMβ2 Avidity in Polymorphonuclear Neutrophils

1998 • 140 citations

The small GTP-binding proteins, Rac and Rho, regulate cytoskeletal organization and exocytosis in mast cells by parallel pathways.

1996 • 130 citations

Intracellular pH regulation during spreading of human neutrophils.

1996 • 128 citations

Subcellular localization and quantitation of the major neutrophil pertussis toxin substrate, Gn.

1988 • 94 citations

The phosphatidylinositol 3-kinase inhibitor wortmannin markedly reduces chemotactic peptide-induced locomotion and increases in cytoskeletal actin in human neutrophils

1997 • 81 citations

Low-molecular-weight GTP-binding proteins and leukocyte signal transduction

1995 • 61 citations

The Renaturable 69- and 63-kDa Protein Kinases That Undergo Rapid Activation in Chemoattractant-stimulated Guinea Pig Neutrophils Are p21-Activated Kinases

1996 • 59 citations

Spreading of differentiating human monocytes is associated with a major increase in membrane-bound CDC42.

1994 • 46 citations

Actin polymerization and leukocyte function.

1994 • 45 citations

Rho GTPases and leukocyte cytoskeletal regulation

1997 • 40 citations

Signaling mechanisms in human neutrophils

1995 • 40 citations

Involvement of CD44 and the cytoskeletal linker protein ankyrin in human neutrophil bacterial phagocytosis

1996 • 35 citations