Neutrophils Stimulated with a Variety of Chemoattractants Exhibit Rapid Activation of p21-Activated Kinases (Paks): Separate Signals Are Required for Activation and Inactivation of Paks

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins

1991 • 2,195 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

1997 • 990 citations

PLATELET ACTIVATING FACTOR: A BIOLOGICALLY ACTIVE PHOSPHOGLYCERIDE

1986 • 781 citations

PAK Kinases Are Directly Coupled to the PIX Family of Nucleotide Exchange Factors

1998 • 745 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

1997 • 687 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Expression of Constitutively Active α-PAK Reveals Effects of the Kinase on Actin and Focal Complexes

1997 • 560 citations

Multistep Navigation and the Combinatorial Control of Leukocyte Chemotaxis

1997 • 531 citations

Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

1997 • 422 citations

C5A Anaphylatoxin and Its Seven Transmembrane-Segment Receptor

1994 • 418 citations

Regulation of Human Leukocyte p21-Activated Kinases Through G Protein—Coupled Receptors

1995 • 415 citations

Identification of a Mouse p21Cdc42/Rac Activated Kinase

1995 • 395 citations

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.

1995 • 365 citations

The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.

1994 • 342 citations

p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-alpha or FMLP stimulation.

1998 • 336 citations

A Conserved Negative Regulatory Region in αPAK: Inhibition of PAK Kinases Reveals Their Morphological Roles Downstream of Cdc42 and Rac1

1998 • 325 citations

Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases

1997 • 314 citations

Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP.

1997 • 311 citations

Signal transduction and actin filament organization

1996 • 309 citations

Interaction of the Nck Adapter Protein with p21-activated Kinase (PAK1)

1996 • 309 citations

Regulation of Phosphorylation Pathways by p21 GTPases

1996 • 300 citations

Actions of Rho Family Small G Proteins and p21-Activated Protein Kinases on Mitogen-Activated Protein Kinase Family Members

1996 • 275 citations

p38 Mitogen-Activated Protein Kinase Activation Is Required for Human Neutrophil Function Triggered by TNF-α or FMLP Stimulation

1998 • 269 citations

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

1996 • 268 citations

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck

1997 • 259 citations

Molecular Cloning of a New Member of the p21-Cdc42/Rac-activated Kinase (PAK) Family

1995 • 240 citations

Interaction of a G-protein β-subunit with a conserved sequence in Ste20/PAK family protein kinases

1998 • 223 citations

Irreversible inhibition of v-src tyrosine kinase activity by herbimycin a and its abrogation by sulfhydryl compounds

1989 • 217 citations

Rhodopsin-family receptors associate with small G proteins to activate phospholipase D

1998 • 211 citations

A new Rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappa B signalling pathways

1998 • 208 citations

Regulation of leukocyte rolling and adhesion to high endothelial venules through the cytoplasmic domain of L-selectin.

1993 • 206 citations

A GTPase-independent Mechanism of p21-activated Kinase Activation

1998 • 204 citations

Specific interactions of chemoattractant factor receptors with G-proteins

1993 • 199 citations

Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes.

1985 • 192 citations

Signaling Functions of L-selectin

1995 • 190 citations

Chemotactic Peptide N-formyl-Met-Leu-Phe Activation of p38 Mitogen-activated Protein Kinase (MAPK) and MAPK-activated Protein Kinase-2 in Human Neutrophils

1997 • 184 citations

Importance of MEK in Neutrophil Microbicidal Responsiveness

1998 • 155 citations

Receptor class desensitization of leukocyte chemoattractant receptors.

1991 • 146 citations

Direct demonstration of the lectin activity of gp90MEL, a lymphocyte homing receptor.

1990 • 134 citations

Inhibition of epidermal growth factor‐induced DNA synthesis by tyrosine kinase inhibitors

1990 • 132 citations

Tyrosine phosphorylation and activation of a new mitogen-activated protein (MAP)-kinase cascade in human neutrophils stimulated with various agonists

1996 • 131 citations

Antagonists of Phosphatidylinositol 3-Kinase Block Activation of Several Novel Protein Kinases in Neutrophils

1995 • 127 citations

The Type I Angiotensin II Receptor Couples to Stat1 and Stat3 Activation Through Jak2 Kinase in Neonatal Rat Cardiac Myocytes

1997 • 122 citations

Activation of Myosin-I by Members of the Ste20p Protein Kinase Family

1996 • 100 citations

Activation of MEKK by Formyl-methionyl-leucyl-phenylalanine in Human Neutrophils

1996 • 88 citations

Contrasting responses to multiple chemotactic stimuli in transendothelial migration: heterologous desensitization in neutrophils and augmentation of migration in eosinophils.

1997 • 87 citations

The phosphatidylinositol 3-kinase inhibitor wortmannin markedly reduces chemotactic peptide-induced locomotion and increases in cytoskeletal actin in human neutrophils

1997 • 81 citations

Activation of p21-CDC42/Rac-Activated Kinases by CD28 Signaling: p21-Activated Kinase (PAK) and MEK Kinase 1 (MEKK1) May Mediate the Interplay Between CD3 and CD28 Signals

1998 • 80 citations

p21-activated kinase has substrate specificity similar to Acanthamoeba myosin I heavy chain kinase and activates Acanthamoeba myosin I

1997 • 79 citations

Myosin I Overexpression Impairs Cell Migration

1997 • 78 citations

Differential Effects of a Mitogen-Activated Protein Kinase Kinase Inhibitor on Human Neutrophil Responses to Chemotactic Factors

1997 • 72 citations

Chemoattractant-stimulated GTPase activity is decreased on membranes from polymorphonuclear leukocytes incubated in chemoattractant

1989 • 69 citations

Protein phosphatase inhibitors okadaic acid and calyculin A alter cell shape and F-actin distribution and inhibit stimulus-dependent increases in cytoskeletal actin of human neutrophils

1992 • 69 citations

The Renaturable 69- and 63-kDa Protein Kinases That Undergo Rapid Activation in Chemoattractant-stimulated Guinea Pig Neutrophils Are p21-Activated Kinases

1996 • 59 citations

Synergistic activation of PtdIns 3-kinase by tyrosine-phosphorylated peptide and βγ-subunits of GTP-binding proteins

1996 • 55 citations

Stimulation of neutrophils with a chemoattractant activates several novel protein kinases that can catalyze the phosphorylation of peptides derived from the 47-kDa protein component of the phagocyte oxidase and myristoylated alanine-rich C kinase substrate

1993 • 55 citations

Characterization of two different forms of mitogen-activated protein kinase kinase induced in polymorphonuclear leukocytes following stimulation by N-formylmethionyl-leucyl-phenylalanine or granulocyte-macrophage colony-stimulating factor

1994 • 54 citations

Receptor-mediated activation of multiple serine/threonine kinases in human leukocytes.

1993 • 51 citations

Neutrophils stimulated with a chemotactic peptide or a phorbol ester exhibit different alterations in the activities of a battery of protein kinases.

1993 • 39 citations

[19] NADH oxidase from guinea pig polymorphonuclear leukocytes

1986 • 34 citations

Serine/threonine kinase activation in human neutrophils: relationship to tyrosine phosphorylation

1994 • 25 citations

1‐O‐hexadecyl‐2‐acetyl‐sn‐glycero‐3‐phospho (N,N,N trimethyl) hexanolamine: an analogue of platelet‐activating factor with partial agonist activity

1991 • 20 citations

Products of Sphingolipid Catabolism Block Activation of the p21-Activated Protein Kinases in Neutrophils

1998 • 14 citations

Stimulation of a histone H4 protein kinase in Triton X‐100 lysates of rabbit peritoneal neutrophils pretreated with chemotactic factors: Lack of requirements of calcium mobilization and protein kinase C activation

1990 • 12 citations

Activation of the p21‐activated protein kinases from neutrophils with an antibody that reacts with the N‐terminal region of Pak 1

1997 • 6 citations

Deleted Work

1955 • 0 citations