Immunological Aspects of Experimental Allergic Encephalomyelitis and Multiple Sclerosis

Adhesion receptors of the immune system

1990 • 6,585 citations

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system

1974 • 2,058 citations

Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis

1993 • 2,032 citations

Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis

1993 • 1,908 citations

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

1992 • 1,711 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains.

1994 • 1,400 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

Endothelial-Leukocyte Adhesion Molecules

1993 • 1,324 citations

The Molecular Cell Biology of Interferon-gamma and its Receptor

1993 • 1,323 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

The Biochemistry and Cell Biology of Antigen Processing and Presentation

1993 • 1,022 citations

Immunological Aspects of Demyelinating Diseases

1992 • 1,021 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

Large Scale Preparation of Myelin Basic Protein from Central Nervous Tissue of Several Mammalian Species

1972 • 949 citations

Amino Acid Homology Between the Encephalitogenic Site of Myelin Basic Protein and Virus: Mechanism for Autoimmunity

1985 • 941 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

1981 • 917 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

HLA and Disease Associations

1985 • 893 citations

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 838 citations

A novel neuronal messenger molecule in brain: The free radical, nitric oxide

1992 • 837 citations

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.

1993 • 837 citations

Gamma/Delta Cells

1993 • 819 citations

Peptides Naturally Presented by MHC Class I Molecules

1993 • 803 citations

Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis

1991 • 794 citations

Cellular immune reactivity within the CNS

1986 • 771 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

Treatment of multiple sclerosis with gamma interferon

1987 • 739 citations

Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein.

1988 • 721 citations

Vβ-Specific Stimulation of Human T Cells by Staphylococcal Toxins

1989 • 711 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

1993 • 688 citations

Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system.

1991 • 675 citations

Inducible expression of H–2 and Ia antigens on brain cells

1984 • 656 citations

A Population-Based Study of Multiple Sclerosis in Twins

1986 • 644 citations

Chronic progressive myelopathy associated with elevated antibodies to human T‐lymphotropic virus type I and adult T‐cell leukemialike cells

1987 • 634 citations

OBSERVATIONS ON ATTEMPTS TO PRODUCE ACUTE DISSEMINATED ENCEPHALOMYELITIS IN MONKEYS

1933 • 629 citations

The outline structure of the T-cell alpha beta receptor.

1988 • 625 citations

Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease

1990 • 603 citations

Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis

1993 • 592 citations

Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1+ 2- T lymphocytes.

1981 • 592 citations

Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis

1989 • 588 citations

CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.

1991 • 562 citations

Pathogenesis of lentivirus infections

1986 • 558 citations

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

1988 • 555 citations

TRANSFER OF ALLERGIC ENCEPHALOMYELITIS IN RATS BY MEANS OF LYMPH NODE CELLS

1960 • 540 citations

Role of Lymphocyte Adhesion Receptors in Transient Interactions and Cell Locomotion

1991 • 532 citations

Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenics

1992 • 531 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination

1985 • 522 citations

MHC Class-II Molecules and Autoimmunity

1991 • 521 citations

Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein

1981 • 520 citations

The epidemiology of multiple sclerosis

2016 • 505 citations

Determinant spreading and the dynamics of the autoimmune T-cell repertoire

1993 • 467 citations

Stress Proteins and Immunology

1990 • 458 citations

Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy.

1991 • 450 citations

Structure, Organization and Polymorphism of Murine and Human T‐Cell Receptor a and β Chain Gene Families

1988 • 448 citations

T Cells Responsive to Myelin Basic Protein in Patients with Multiple Sclerosis

1990 • 447 citations

Anti—tumor necrosis factor therapy abrogates autoimmune demyelination

1991 • 434 citations

Biology of disease. Analysis of autoimmune demyelination: its impact upon multiple sclerosis.

1984 • 424 citations

A population‐based study of multiple sclerosis in twins: Update

1993 • 420 citations

Vaccination Against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides

1989 • 416 citations

Multiple Sclerosis

1982 • 415 citations

Measles Encephalomyelitis — Clinical and Immunologic Studies

1984 • 404 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments.

1988 • 404 citations

Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice.

1991 • 400 citations

Selection for T-cell receptor Vβ–Dβ–Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis

1993 • 400 citations

Limited heterogeneity of rearranged T-cell receptor Vα transcripts in brains of multiple sclerosis patients

1990 • 395 citations

Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy

1989 • 394 citations

Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype

1989 • 390 citations

Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system.

1990 • 388 citations

Shared Human T Cell Receptor V _β Usage to Immunodominant Regions of Myelin Basic Protein

1990 • 386 citations

Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-beta 1.

1991 • 385 citations

A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules

1988 • 384 citations

Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions

1986 • 383 citations

Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.

1989 • 372 citations

Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma.

1990 • 363 citations

Differential Regulation of Murine T Lymphocyte Subsets

1993 • 343 citations

Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals.

1990 • 342 citations

Experimental Allergic Encephalomyelitis. A Useful Model for Multiple Sclerosis

1984 • 340 citations

Myelin basic protein‐specific T lymphocyte lines from MS patients and healthy individuals

1990 • 332 citations

Multiple sclerosis. Updated risks for relatives

1988 • 330 citations

Using gadolinium‐enhanced magnetic resonance imaging lesions to monitor disease activity in multiple sclerosis

1992 • 328 citations

Reversal of Experimental Allergic Encephalomyelitis with Monoclonal Antibody to a T-Cell Subset Marker

1985 • 328 citations

Suppression of experimentally induced autoimmune encephalomyelitis by cytolytic T–T cell interactions

1988 • 324 citations

Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones.

1994 • 323 citations

Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different.

1989 • 321 citations

Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein.

1993 • 319 citations

Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation

1989 • 317 citations

Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain.

1986 • 316 citations

T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis.

1991 • 314 citations

T Cells Against a Bacterial Heat Shock Protein Recognize Stressed Macrophages

1989 • 310 citations

Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors.

1990 • 307 citations

Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations.

1992 • 306 citations

Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain.

1993 • 305 citations

Molecular Components of T-Cell Recognition

1992 • 304 citations

Interactions between Immunogenic Peptides and MHC Proteins

1991 • 303 citations

Serial gadolinium‐enhanced magnetic resonance imaging scans in patients with early, relapsing‐remitting multiple sclerosis: Implications for clinical trials and natural history

1991 • 295 citations

Central nervous system demyelination and remyelination in the mouse: an ultrastructural study of cuprizone toxicity.

1978 • 293 citations

Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis

1983 • 287 citations

A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis.

1991 • 286 citations

MHC-Restricted Depletion of Human Myelin Basic Protein-Reactive T Cells by T Cell Vaccination

1993 • 286 citations

Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity

1990 • 285 citations

Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis.

1991 • 285 citations

Proteins of Myelin

1977 • 281 citations

Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: influence of MHC binding affinity

1993 • 280 citations

Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions.

1992 • 280 citations

Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis.

1993 • 277 citations

Concepts in Viral Pathogenesis

1984 • 272 citations

Class II MHC molecules can use the endogenous pathway of antigen presentation

1990 • 271 citations

Isolation of myelin basic protein-reactive T-cell lines from normal human blood

1983 • 270 citations

T cells specific for the myelin oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system

1993 • 265 citations

Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: process of selection of lines and characterization of the cells.

1982 • 261 citations

Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen

1993 • 260 citations

Anxiety, impulsivity and depressed mood in relation to suicidal and violent behavior

1993 • 259 citations

Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls

1991 • 258 citations

Adrenoleukodystrophy: Survey of 303 cases: Biochemistry, diagnosis, and therapy

1984 • 256 citations

Suppressor cell function in multiple sclerosis: Correlation with clinical disease activity

1979 • 251 citations

Successful treatment of experimental allergic encephalomyelitis with transforming growth factor-beta 1.

1991 • 243 citations

Sequence Homology Between Certain Viral Proteins and Proteins Related to Encephalomyelitis and Neuritis

1985 • 243 citations

The morbid anatomy of the demyelinative diseases

1952 • 243 citations

Theiler's Virus-Induced Demyelination: Prevention by Immunosuppression

1976 • 242 citations

On the presence of Ia-positive endothelial cells and astrocytes in multiple sclerosis lesions and its relevance to antigen presentation

1985 • 241 citations

Selective Loss of the Suppressor-Inducer T-Cell Subset in Progressive Multiple Sclerosis

1987 • 240 citations

Primarily chronic progressive and relapsing/remitting multiple sclerosis: two immunogenetically distinct disease entities.

1989 • 239 citations

Preferential T-cell receptor beta-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis.

1991 • 237 citations

Clinical worsening in multiple sclerosis is associated with increased frequency and area of gadopentetate dimeglumine–enhancing magnetic resonance imaging lesions

1993 • 237 citations

Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis.

1990 • 234 citations

Adoptive transfer of EAE-like lesions from rats with coronavirus-induced demyelinating encephalomyelitis

1983 • 233 citations

Induction of active and adoptive relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein

1992 • 231 citations

Homing to central nervous system vasculature by antigen-specific lymphocytes. II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination.

1990 • 229 citations

In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis.

1981 • 228 citations

Experimental allergic encephalomyelitis: successful treatment in vivo with a monoclonal antibody that recognizes T helper cells.

1984 • 222 citations

A susceptibility locus for multiple sclerosis is linked to the T cell receptor β chain complex

1989 • 219 citations

Oligodendrocytes in the early course of multiple sclerosis

1994 • 215 citations

Ia-restricted encephalitogenic T lymphocytes mediating EAE lyse autoantigen-presenting astrocytes

1986 • 214 citations

HLA-DQ is epistatic to HLA-DR in controlling the immune response to schistosomal antigen in humans

1987 • 212 citations

Demyeliating neuropathy and monoclonal IgM antibody to myelin‐associated glycoprotein

1983 • 207 citations

The Isolation, Characterization, and Lipid-aggregating Properties of a Citrulline Containing Myelin Basic Protein

1989 • 206 citations

Characterization of Theiler's murine encephalomyelitis virus (TMEV)-specific delayed-type hypersensitivity responses in TMEV-induced demyelinating disease: correlation with clinical signs.

1986 • 206 citations

T Cell Receptor Peptide Therapy Triggers Autoregulation of Experimental Encephalomyelitis

1991 • 202 citations

Control of Experimental Autoimmune Encephalomyelitis by T Cells Responding to Activated T Cells

1989 • 197 citations

Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients.

1993 • 196 citations

Myelin encephalitogenic protein fragments in cerebrospinal fluid of persons with multiple sclerosis

1977 • 195 citations

Restricted T-cell receptor V beta gene usage by myelin basic protein-specific T-cell clones in multiple sclerosis: predominant genes vary in individuals.

1991 • 193 citations

Effect of cloned interferon‐γ on expression of H‐2 and Ia antigens on cell lines of hemopoietic, lymphoid, epithelial, fibroblastic and neuronal origin

1984 • 192 citations

The V-region disease hypothesis: evidence from autoimmune encephalomyelitis

1989 • 190 citations

Multiple Sclerosis

1982 • 190 citations

An endogenous processing pathway in vaccinia virus-infected cells for presentation of cytoplasmic antigens to class II-restricted T cells.

1990 • 188 citations

Inhibition of experimental autoimmune encephalomyelitis by an antibody to the intercellular adhesion molecule ICAM‐1

1993 • 186 citations

Amplification and Molecular Cloning of HTLV-I Sequences from DNA of Multiple Sclerosis Patients

1989 • 184 citations

Oral tolerance in experimental autoimmune uveoretinitis. Distinct mechanisms of resistance are induced by low dose vs high dose feeding protocols.

1993 • 184 citations

A STUDY OF THE CRYSTALLINE ALBUMIN, GAMMA GLOBULIN AND TOTAL PROTEIN IN THE CEREBROSPINAL FLUID OF ONE HUNDRED CASES OF MULTIPLE SCLEROSIS AND IN OTHER DISEASES

1950 • 184 citations

Experimental autoimmune encephalomyelitis is exacerbated by IL-1 alpha and suppressed by soluble IL-1 receptor.

1991 • 183 citations

Proteins of Myelin

1984 • 183 citations

Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis.

1988 • 179 citations

Individual exons encode the integral membrane domains of human myelin proteolipid protein.

1986 • 177 citations

A placebo‐controlled, double‐blind, randomized, two‐center, pilot trial of Cop 1 in chronic progressive multiple sclerosis

1991 • 176 citations

CD4+ suppressor cells inhibit the function of effector cells of experimental autoimmune encephalomyelitis through a mechanism involving transforming growth factor-beta.

1991 • 175 citations

Upregulation and coexpression of adhesion molecules correlate with relapsing autoimmune demyelination in the central nervous system.

1990 • 173 citations

Expression of immunologically relevant endothelial cell activation antigens on isolated central neurvous system microvessels from patients with multiple sclerosis

1994 • 170 citations

Multiple Sclerosis as a Disease of Immune Regulation

1984 • 169 citations

Prevention and treatment of murine experimental allergic encephalomyelitis with T cell receptor V beta-specific antibodies.

1990 • 164 citations

Activated terminal complement in cerebrospinal fluid in Guillain-Barré syndrome and multiple sclerosis.

1986 • 163 citations

THE DIFFERENTIAL DIAGNOSIS OF NEUROLOGICAL DISEASES BY FRACTIONATING ELECTRO‐PHORETICALLY THE CSF γ‐GLOBULINS*

1960 • 163 citations

Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis

1992 • 163 citations

T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions.

1992 • 163 citations

T cell receptor β chain usage in myelin basic protein‐specific rat T lymphocytes

1989 • 162 citations

INTERACTIONS BETWEEN OLIGODENDROCYTES AND MICROGLIA

1992 • 161 citations

Identification of three forms of human myelin basic protein by cDNA cloning.

1986 • 161 citations

T-cell receptor V alpha and C alpha alleles associated with multiple and myasthenia gravis.

1989 • 158 citations

Myelin‐specific proteolipid protein is expressed in myelinating schwann cells but is not incorporated into myelin sheaths

1987 • 154 citations

Major histocompatibility complex-linked control of the murine immune response to myelin basic protein.

1985 • 154 citations

Pathophysiology of the blood-brain barrier

1990 • 153 citations

Myelin basic protein–specific T lymphocytes in multiple sclerosis and controls: Precursor frequency, fine specificity, and cytotoxicity

1992 • 149 citations

Diversity in fine specificity and T cell receptor usage of the human CD4+ cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106.

1992 • 148 citations

The germline repertoire of T cell receptor β-chain genes in patients with chronic progressive multiple sclerosis

1989 • 147 citations

Gamma/Delta T Cells

1993 • 146 citations

Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones.

1993 • 145 citations

Experimental Autoimmune Encephalomyelitis in Mice: Immunologic Response to Mouse Spinal Cord and Myelin Basic Proteins

1975 • 145 citations

Adoptive Transfer of Experimental Allergic Encephalomyelitis: Incubation of Rat Spleen Cells with Specific Antigen

1979 • 144 citations

Clonal expansions of activated gamma/delta T cells in recent-onset multiple sclerosis.

1993 • 141 citations

HLA-DQA1 and HLA-DQB1 genes may jointly determine susceptibility to develop multiple sclerosis

1991 • 140 citations

Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides.

1990 • 140 citations

Experimental Allergic Encephalomyelitis: Enhancement of Cell-Mediated Transfer by Concanavalin A

1977 • 139 citations

T Cell Receptors in Murine Autoimmune Diseases

1989 • 137 citations

T cell activation in Guillain‐Barré syndrome and in MS

1990 • 137 citations

T Helper 1 (TH1) Functional Phenotype of Human Myelin Basic Protein-Specific T Lymphocytes

1993 • 136 citations

Oral Tolerance in Experimental Autoimmune Encephalomyelitis

1996 • 136 citations

Prevention of experimental encephalomyelitis with peptides that block interaction of T cells with major histocompatibility complex proteins.

1989 • 135 citations

Microglia in the immune surveillance of the brain: Human microglia constitutively express HLA-DR molecules

1993 • 134 citations

Skewed T-cell receptor repertoire in genetically identical twins correlates with multiple sclerosis

1993 • 134 citations

Isolation of HTLV‐II from a patient with chronic, progressive neurological disease clinically indistinguishable from HTLV‐I‐associated myelopathy/tropical spastic paraparesis

1993 • 133 citations

INTERACTIONS BETWEEN OLIGODENDROCYTES AND MICROGLIA

1992 • 133 citations

Cytokine-regulated adhesion between encephalitogenic T lymphocytes and cerebrovascular endothelial cells

1993 • 131 citations

Structure and expression of the mouse myelin proteolipid protein gene

1987 • 130 citations

Transfėr of Allergic Encephalomyelitis by Lymph Node Cells in Inbred Guinea Pigs

1961 • 128 citations

Peripheral blood γ‐δ T cells lyse fresh human brain—Derived oligodendrocytes

1991 • 128 citations

Restricted replication of lentiviruses. Visna viruses induce a unique interferon during interaction between lymphocytes and infected macrophages.

1985 • 127 citations

Myelin basic protein and proteolipid protein reactivity of brain- and cerebrospinal fluid-derived T cell clones in multiple sclerosis and postinfectious encephalomyelitis.

1987 • 127 citations

A synthetic peptide from myelin proteolipid protein induces experimental allergic encephalomyelitis.

1988 • 126 citations

Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis

1986 • 124 citations

The T-Cell Receptor Repertoire and Autoimmune Diseases

1989 • 124 citations

Requirement for CD8⁺Cells in T Cell Receptor Peptide-Induced Clonal Unresponsiveness

1993 • 122 citations

Staphylococcal enterotoxins can reactivate experimental allergic encephalomyelitis.

1993 • 119 citations

Chromatographic Fractionation of Myelin Basic Protein

1973 • 118 citations

Inhibition of experimental autoimmune encephalomyelitis induction in SJL/J mice by using a peptide with high affinity for IAs molecules.

1990 • 118 citations

Immunological studies in tropical spastic paraparesis

1990 • 118 citations

Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis

1992 • 117 citations

Interaction between myelin basic protein-sensitized T lymphocytes and murine cerebral vascular endothelial cells.

1986 • 117 citations

Sardinian multiple sclerosis is associated with HLA‐DR4

1988 • 116 citations

A HYPERACUTE FORM OF ALLERGIC ENCEPHALOMYELITIS.

1965 • 116 citations

Immunohistochemical analysis of the immune reaction in the nervous system in paraneoplastic encephalomyelitis

1990 • 115 citations

Specific inhibition of the T-cell response to myelin basic protein by the synthetic copolymer Cop 1.

1988 • 115 citations

The Gene Encoding the Oligodendrocyte-Myelin Glycoprotein Is Embedded within the Neurofibromatosis Type 1 Gene

1991 • 114 citations

Adhesion molecule expression on cerebrospinal fluid T lymphocytes: Evidence for common recruitment mechanisms in multiple sclerosis, aseptic meningitis, and normal controls

1993 • 114 citations

Class II HLA-DC beta-chain DNA restriction fragments differentiate among HLA-DR2 individuals in insulin-dependent diabetes and multiple sclerosis.

1984 • 113 citations

Tumor necrosis factor alpha production as a possible predictor of relapse in patients with multiple sclerosis.

1992 • 112 citations

CD4⁺ suppressor cells of autoimmune encephalomyelitis respond to T cell receptor‐associated determinants on effector cells by interleukin‐4 secretion

1992 • 108 citations

Major histocompatibility complex-expressing nonhematopoietic astroglial cells prime only CD8+ T lymphocytes: astroglial cells as perpetuators but not initiators of CD4+ T cell responses in the central nervous system.

1991 • 107 citations

Split tolerance of T_hl and T_h2 cells in tolerance to Theiler's murine encephalomyelitis virus

1993 • 107 citations

DIFFERENT B LYMPHOCYTE ALLOANTIGENS ASSOCIATED WITH MULTIPLE SCLEROSIS IN ARABS AND NORTH EUROPEANS

1977 • 104 citations

Antigen-specific therapy of experimental allergic encephalomyelitis by soluble class II major histocompatibility complex-peptide complexes.

1991 • 103 citations

Functional capacity of solid tissue transplants in the brain: evidence for immunological privilege

1985 • 102 citations

Anti-adhesion molecule therapy in experimental autoimmune encephalomyelitis

1993 • 102 citations

PURIFICATION AND IMMUNOHISTOCHEMICAL LOCALIZATION OF RAT BRAIN MYELIN PROTEOLIPID PROTEIN¹

1977 • 102 citations

On the immunopathology of plaque development and repair in multiple sclerosis

1988 • 102 citations

Immune‐mediated demyelination

1993 • 99 citations

T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats.

1989 • 98 citations

Patients with multiple sclerosis carry DQB1 genes which encode shared polymorphic amino acid sequences

1989 • 97 citations

Borrelia burgdorferi—specific and autoreactive T‐cell lines from cerebrospinal fluid in lyme radiculomyelitis

1988 • 97 citations

Immunity to TCR peptides in multiple sclerosis. I. Successful immunization of patients with synthetic V beta 5.2 and V beta 6.1 CDR2 peptides.

1994 • 96 citations

HL-A Antigen Frequencies in Multiple Sclerosis

1972 • 96 citations

Susceptibility for multiple sclerosis is determined, in part, by inheritance of a 175-kb region of the TcR Vβ chain locus and HLA class II genes

1993 • 94 citations

Organization and expression of the human myelin basic protein gene

1988 • 92 citations

Immunomodulation of experimental allergic encephalomyelitis by antibodies to the antigen–Ia complex

1991 • 92 citations

The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene.

1991 • 91 citations

γδ T cell receptor repertoire in brain lesions of patients with multiple sclerosis

1993 • 89 citations

Encephalitogenic Epitopes of Myelin Basic Protein

1989 • 89 citations

Demyelinating lesions due to Theiler's virus are associated with ongoing central nervous system infection

1986 • 89 citations

Immunohistochemical studies of adult human glial cells

1989 • 89 citations

Response of human T lymphocyte lines to myelin basic protein: Association of dominant epitopes with HLA class II restriction molecules

1989 • 88 citations

Immunoglobulin G heavy chain (Gm) allotypes in multiple sclerosis.

1981 • 87 citations

Where, when, and how to detect biased expression of disease-relevant V beta genes in rats with experimental autoimmune encephalomyelitis.

1993 • 86 citations

Opportunistic central nervous system pathology in patients with AIDS

1988 • 86 citations

Parent‐child concordance in multiple sclerosis

1991 • 86 citations

The expression of MHC antigens on oligodendrocytes: Induction of polymorphic H-2 expression by lymphokines

1986 • 84 citations

Myelin proteolipid protein induces demyelinating disease in mice

1987 • 83 citations

Developmental profile and differential localization of mRNAs of myelin proteins (MBP and PLP) in oligodendrocytes in the brain and in culture

1989 • 82 citations

Diversity of T cell receptor α and β chain genes expressed by human T cells specific for similar myelin basic protein peptide/major histocompatibility complexes

1992 • 82 citations

Induction of autoimmune reactions to myelin basic protein in measles virus encephalitis in Lewis rats

1988 • 81 citations

Autoimmune T cells: Immune recognition of normal and variant peptide epitopes and peptide-based therapy

1989 • 81 citations

Copolymer-1-induced inhibition of antigen-specific T cell activation: interference with antigen presentation

1992 • 81 citations

Virus-reactive and autoreactive T cells are accumulated in cerebrospinal fluid in multiple sclerosis

1992 • 81 citations

Identification of a major encephalitogenic epitope of proteolipid protein (residues 56-70) for the induction of experimental allergic encephalomyelitis in Biozzi AB/H and nonobese diabetic mice.

1993 • 80 citations

Experimental allergic encephalomyelitis induced by proteolipid apoprotein in Lewis rats

1986 • 78 citations

Chronologic localization of myelin‐reactive cells in the lesions of relapsing EAE

1993 • 78 citations

Identification of a novel T cell epitope of human proteolipid protein (residues 40–60) recognized by proliferative and cytolytic CD4+ T cells from multiple sclerosis patients

1993 • 77 citations

Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction.

1990 • 77 citations

Expression of heat shock protein‐65 by oligodendrocytes in vivo and in vitro

1992 • 75 citations

Chronic experimental allergic encephalomyelitis in guinea pigs induced by proteolipid protein

1985 • 75 citations

Augmentation of adoptively transferred experimental allergic encephalomyelitis by administration of a monoclonal antibody specific for LFA-1α

1993 • 74 citations

Long-term treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-β2

1993 • 74 citations

Comprehensive virology 17

1982 • 73 citations

A prospective study of physical trauma and multiple sclerosis.

1991 • 73 citations

Location of a new encephalitogenic epitope (residues 43 to 64) in proteolipid protein that induces relapsing experimental autoimmune encephalomyelitis in PL/J and (SJL x PL)F1 mice.

1991 • 72 citations

HLA‐DP antigens are involved in the susceptibility to multiple sclerosis

1988 • 71 citations

Genetic susceptibility in familial multiple sclerosis not linked to the myelin basic protein gene

1993 • 71 citations

Monoclonal antibody to Theiler's murine encephalomyelitis virus defines a determinant on myelin and oligodendrocytes, and augments demyelination in experimental allergic encephalomyelitis.

1990 • 70 citations

Treatment of multiple sclerosis

1994 • 70 citations

Allergic encephalomyelitis. Isolation of an encephalitogenic peptide active in the monkey.

1975 • 69 citations

Fc receptor density, MHC antigen expression and superoxide production are increased in interferon-gamma-treated microglia isolated from adult rat brain.

1989 • 69 citations

T cells in the lesion of experimental autoimmune encephalomyelitis. Enrichment for reactivities to myelin basic protein and to heat shock proteins.

1992 • 68 citations

Impaired measles virus-specific cytotoxic T cell responses in multiple sclerosis.

1985 • 68 citations

MRI in familial multiple sclerosis

1990 • 68 citations

DM-20, a proteolipid apoprotein, is an encephalitogen of acute and relapsing autoimmune encephalomyelitis in mice.

1986 • 67 citations

Experimental autoimmune encephalomyelitis. Augmentation of demyelination by different myelin lipids.

1984 • 67 citations

No association with germline T cell receptor β-chain gene alleles or haplotypes in Swedish patients with multiple sclerosis

1991 • 67 citations

DNA length polymorphism 5′ to the myelin basic protein gene is associated with multiple sclerosis

1990 • 67 citations

Predominant and stable T cell responses to regions of myelin basic protein can be detected in individual patients with multiple sclerosis

1993 • 66 citations

Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction. II. Fine specificity of effector T cell inhibition.

1992 • 66 citations

Immunosuppressive activity of 13-cis-retinoic acid and prevention of experimental autoimmune encephalomyelitis in rats.

1991 • 66 citations

Induction of autoimmune disease in mice by germline alteration of the T cell receptor gene expression.

1994 • 65 citations

Evidence for multiple human T cell recognition sites on myelin basic protein

1989 • 65 citations

Immunogenetic profile of multiple sclerosis in Mexicans

1986 • 64 citations

Immunity to TCR peptides in multiple sclerosis. II. T cell recognition of V beta 5.2 and V beta 6.1 CDR2 peptides.

1994 • 63 citations

Chronic experimental autoimmune encephalomyelitis induced by the 89‐101 myelin basic protein peptide in B10RIII (H2^r) mice

1991 • 63 citations

Peripheral blood mononuclear cells from multiple sclerosis patients recognize myelin proteolipid protein and selected peptides

1991 • 63 citations

HLA and Japanese MS.

1978 • 62 citations

Persistent intrathecal secretion of oligoclonal, Borrelia burgdorferi-specific IgG in chronic meningoradiculomyelitis

1988 • 62 citations

Discordance of T‐cell receptor β‐chain genes in familial multiple sclerosis

1991 • 61 citations

HLA-DR2a is the dominant restriction molecule for the cytotoxic T cell response to myelin basic protein in DR2Dw2 individuals.

1990 • 60 citations

Epidemiology and genetics of multiple sclerosis.

1992 • 60 citations

Antigen-specific damage to brain vascular endothelial cells mediated by encephalitogenic and nonencephalitogenic CD4+ T cell lines in vitro.

1990 • 59 citations

The T‐cell response to myelin basic protein in familial multiple sclerosis: Diversity of fine specificity, restricting elements, and T‐cell receptor usage

1993 • 59 citations

HLA-DPβ and susceptibility to multiple sclerosis: An analysis of caucasoid and Japanese patient populations

1990 • 58 citations

Takayasu's Disease: Association with HLA‐B5

1978 • 56 citations

Neurological autoimmune disease and the trimolecular complex of T‐lymphocytes

1989 • 56 citations

Correlation of interleukin-2 and soluble interleukin-2 receptor with clinical activity of multiple sclerosis.

1993 • 54 citations

Family and Twin Studies in Multiple Sclerosis

1984 • 53 citations

cDNA cloning and amino acid sequence for human myelin-associated glycoprotein

1989 • 52 citations

Selective loss of binocular depth perception after ablation of cat visual cortex

1981 • 52 citations

Myelin basic protein‐specific T‐cell responses in identical twins discordant or concordant for multiple sclerosis

1993 • 51 citations

Differential exon expression in myelin basic protein transcripts during central nervous system (CNS) remyelination

1990 • 50 citations

Protection from experimental allergic encephalomyelitis by application of a bacterial superantigen

1992 • 49 citations

Inducible expression of h-2 and ia antigens on brain cells

1985 • 49 citations

Verbal learning differences in epileptic patients with left and right temporal lobe foci - a pharmacologically induced phenomenon?

2009 • 48 citations

T cell receptor α chain polymorphisms in multiple sclerosis

1992 • 48 citations

The Structure and Function of Central Nervous System Myelin

1993 • 48 citations

Human oligodendrocytes are susceptible to cytolysis by major histocompatibility complex class I-restricted lymphocytes

1990 • 48 citations

Genetic Factors in Multiple Sclerosis

1983 • 47 citations

Markers of Activated T Lymphocytes and T Cell Receptor Gamma/ Delta+ in Patients with Multiple Sclerosis

1993 • 47 citations

Peripheral Blood Lymphocytes Respond Predominantly to Myelin Oligodendrocyte Glycoprotein

1993 • 47 citations

The T‐lymphocyte response against myelin‐associated glycoprotein and myelin basic protein in patients with multiple sclerosis

1993 • 46 citations

Homologies between T cell receptor junctional sequences unique to multiple sclerosis and T cells mediating experimental allergic encephalomyelitis.

1994 • 46 citations

Neuronal and Glial Proteins: Structure, Function, and Clinical Application

1988 • 46 citations

α‐1 antitrypsin phenotypes in demyelinating disease: An association between demyelinating disease and the allele PiM3

1985 • 46 citations

Antigen processing gene polymorphisms in HLA‐DR2 multiple sclerosis

1993 • 45 citations

The presence of immunoreactive myelin basic protein peptide in urine of persons with multiple sclerosis

1987 • 44 citations

Cultured human and rat oligodendrocytes and rat schwann cells do not have immune response gene associated antigen (Ia) on their surface

1983 • 44 citations

Model Systems for Study of Perturbations of Myelin Metabolism

1984 • 43 citations

T‐cell receptor α chain germline gene polymorphisms in multiple sclerosis

1992 • 43 citations

Characterization of rat encephalitogenic T cells bearing non‐V_β8 T cell recepotors

1992 • 43 citations

Identification of a specific HLA DR2 Ia molecule as a restriction element for measles virus-specific HLA class II-restricted cytotoxic T cell clones.

1985 • 42 citations

Heterogeneity of the T‐cell receptor β gene rearrangements generated in myelin basic protein‐specific T‐cell clones isolated from a patient with multiple sclerosis

1991 • 42 citations

The immunopathology of chronic experimental allergic encephalomyelitis induced in rabbits with bovine proteolipid protein.

1986 • 40 citations

Peptide specificities of myelin basic protein‐reactive human T‐cell clones

1988 • 40 citations

Citrulline‐containing myelin basic protein is recognized by T‐cell lines derived from multiple sclerosis patients and healthy individuals

1994 • 39 citations

Nomenclature for factors of the HLA system, 1987

1988 • 39 citations

Human cytotoxic T‐cell recognition of a synthetic peptide of myelin basic protein

1989 • 38 citations

Peptides of myelin basic protein stimulate T lymphocytes from patients with multiple sclerosis

1989 • 38 citations

Analogous amino acid sequences in myelin proteolipid and viral proteins

1986 • 38 citations

cDNA cloning and amino acid sequence of human brain 2′,3′-cyclic-nucleotide 3′-phosphodiesterase

1988 • 37 citations

Passive transfer studies in demyelinating neuropathy with IgM monoclonal antibodies to myelin-associated glycoprotein.

1985 • 37 citations

The clinical profile of MS in Australia

1988 • 35 citations

Neurology

1985 • 34 citations

Adult human glial cells can present target antigens to HLA-restricted cytotoxic T-cells

1990 • 33 citations

A Colour Atlas of Multiple Sclerosis and Other Myelin Disorders

1989 • 33 citations

Experimental allergic encephalomyelitis in cynomolgus monkeys. Quantitation of T cell responses in peripheral blood.

1992 • 33 citations

Correlation between susceptibility to demyelination and interferon-γ induction of major histocompatibility complex class II antigens on murine cerebrovascular endothelial cells

1993 • 33 citations

Distribution of HLA‐SB antigens in multiple sclerosis

1984 • 32 citations

Experimental allergic encephalomyelitis induced by the peptide encoded by exon 2 of the MBP gene, a peptide implicated in remyelination

1994 • 32 citations

Multiple sclerosis-like disease induced in rabbits by immunization with brain gangliosides.

1981 • 31 citations

Characterization of measles virus-induced cellular autoimmune reactions against myelin basic protein in Lewis rats

1990 • 30 citations

Virus-specific and autoreactive T cell lines isolated from cerebrospinal fluid of a patient with chronic rubella panencephalitis

1989 • 29 citations

Susceptibility to Proteolipid Apoprotein and Its Encephalitogenic Determinants in Mice

1990 • 29 citations

Pathogenic and non-pathogenic T lymphocytes specific for the encephalitogenic epitope of myelin basic protein: Functional characteristics and vaccination properties

1993 • 29 citations

An allelic cluster of DQα restriction fragments is associated with multiple sclerosis: Evidence that a second haplotype may influence disease susceptibility

1989 • 29 citations

Myelin basic protein: a dynamically changing structure.

1990 • 29 citations

Myelin basic protein speciation.

1984 • 29 citations

Determinants of human myelin basic protein that induce encephalitogenic T cells in Lewis rats.

1989 • 28 citations

Cardiac dysfunction during status epilepticus in the neonatal pig

1985 • 28 citations

Amino-Acid Sequence of Human and Bovine Brain Myelin Proteolipid Protein (Lipophilin) is Completely Conserved

1985 • 28 citations

Localization of an enciphalitogenic epitope for the SJL mouse in the N-terminal region of myelin basic protein

1990 • 27 citations

Autoimmune Demyelination in the Central Nervous Systema

1988 • 27 citations

Nomenclature for factors of the HLA system, 1989

1990 • 26 citations

Major role of antigen-presenting cells in the response of rat encephalitogenic T cells to myelin basic proteins.

1993 • 25 citations

MYELIN PROTEOLIPID PROTEIN

1988 • 24 citations

An immunochemical comparison of human myelin basic protein and its modified, citrullinated form, C8

1992 • 24 citations

HLA-DR and -DQ allelic sequences in multiple sclerosis patients are identical to those found in the general population

1991 • 23 citations

Virus-induced Autoimmune Demyelinating Disease of the Central Nervous System

1986 • 23 citations

T-lymphocyte recognition of a portion of myelin basic protein encoded by an exon expressed during myelination

1993 • 22 citations

Autoreactive T and B cells in nervous system diseases.

1993 • 21 citations

T cell lines specific for an immunodominant epitope of human basic protein define an encephalitogenic determinant for experimental autoimmune encephalomyelitis-resistant LOU/M rats.

1991 • 21 citations

Multiple sclerosis and HLA class II susceptibility and resistance genes

1990 • 21 citations

Trials of vaccination against experimental autoimmune uveoretinitis with a T-cell receptor peptide

1991 • 20 citations

A functional basis for the association of HLA class II genes adn susceptibility to multiple sclerosis: cellular immune responses to myelin basic protein in a multiplex family

1993 • 20 citations

Influence of HLA-DR2, HLA-DPw4, and T cell receptor α chain genes on the susceptibility to multiple sclerosis

1992 • 19 citations

Molecular Mimicry

1986 • 19 citations

Optic neuritis is associated with myelin basic protein and proteolipid protein reactive cells producing interferon-γ, interleukin-4 and transforming growth factor-β

1994 • 16 citations

Treatment of Multiple Sclerosis with ACTH and Corticosteroids

1992 • 16 citations

Encephalitogenic Epitopes of Myelin Basic Protein

2015 • 16 citations

Modulation of EAE by vaccination with T cell receptor peptides: Vβ8 T cell receptor peptide-specific CD4+ lymphocytes lack direct immunoregulatory activity

1993 • 14 citations

Measles virus‐directed responses of CD4 ⁺ T lymphocytes in MS patients and healthy individuals

1993 • 13 citations

A Colour Atlas of Multiple Sclerosis and Other Myelin Disorders

1989 • 12 citations

Virus-Induced Demyelination

1984 • 12 citations

Multiple sclerosis; part I.

1951 • 12 citations

Human T lymphocytes reactive with whole myelin recognize predominantly myelin basic protein

1989 • 11 citations

Neurological disorders related to HTLV-I and HTLV-II.

1993 • 10 citations

Treatment of Multiple Sclerosis with Cyclophosphamide

1992 • 9 citations

Microheterogeneity of bovine myelin basic protein studied by nuclear magnetic resonance spectroscopy

1983 • 9 citations

Treatment of Multiple Sclerosis with Azathioprine

1992 • 9 citations

Human myelin basic protein-specific cytolytic T lymphocyte clones are functionally restricted by HLA class II gene products

1989 • 7 citations

Cytotoxic effects of myelin basic protein-reactive T cell hybridoma cells on oligodendrocytes

1991 • 2 citations