Anti—tumor necrosis factor therapy abrogates autoimmune demyelination

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

Large Scale Preparation of Myelin Basic Protein from Central Nervous Tissue of Several Mammalian Species

1972 • 949 citations

Tumor necrosis factor identified in multiple sclerosis brain.

1989 • 793 citations

Comparison of in vitro cell cytotoxic assays for tumor necrosis factor

1984 • 752 citations

Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions.

1991 • 735 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1+ 2- T lymphocytes.

1981 • 592 citations

Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha.

1987 • 497 citations

Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro.

1986 • 496 citations

Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: induction of TNF receptors on human T cells and TNF-alpha-mediated enhancement of T cell responses.

1987 • 490 citations

Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes.

1987 • 426 citations

Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species.

1987 • 418 citations

Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors.

1989 • 385 citations

Immunochemistry in Practice

1983 • 355 citations

A monoclonal antibody that detects a novel antigen on endothelial cells that is induced by tumor necrosis factor, IL-1, or lipopolysaccharide.

1990 • 339 citations

Effect of tumor necrosis factor alpha on mitogen-activated human B cells.

1987 • 245 citations

Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis.

1990 • 234 citations

Tumour necrosis factor and lymphotoxin genes map close to H–2D in the mouse major histocompatibility complex

1987 • 230 citations

Experimental allergic encephalomyelitis: successful treatment in vivo with a monoclonal antibody that recognizes T helper cells.

1984 • 222 citations

Enhancement of antigen- and mitogen-induced human T lymphocyte proliferation by tumor necrosis factor-alpha.

1988 • 221 citations

Stimulation of endothelial cell binding of lymphocytes by tumor necrosis factor.

1987 • 197 citations

Production of tumor necrosis factor/cachectin by human T cell lines and peripheral blood T lymphocytes stimulated by phorbol myristate acetate and anti-CD3 antibody.

1988 • 187 citations

Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. Severe paralytic disease correlates with the presence of interleukin 2 receptor-positive cells infiltrating the central nervous system.

1987 • 182 citations

A novel addition to the T cell repertory. Cell surface expression of tumor necrosis factor/cachectin by activated normal human T cells.

1990 • 133 citations

Evidence that leukocyte function-associated antigen-1 is involved in recirculation and homing of human lymphocytes via high endothelial venules.

1988 • 115 citations

Effects of tumor necrosis factor on the interferon‐γ‐induced major histocompatibility complex class II antigen expression by human endothelial cells

1988 • 113 citations

Endothelial cell activation induced by tumor necrosis factor and lymphotoxin.

1989 • 106 citations

Adoptively transferred chronic relapsing experimental autoimmune encephalomyelitis in the mouse. Neuropathologic analysis.

1984 • 86 citations

Experimental autoimmune encephalomyelitis. Augmentation of demyelination by different myelin lipids.

1984 • 67 citations

Identification and characterization of a membrane-bound cytotoxin of murine cytolytic lymphocytes that is related to tumor necrosis factor/cachectin.

1989 • 65 citations

Homing of Lyt-2+ and Lyt-2- T cell subsets and B lymphocytes to the central nervous system of mice with acute experimental allergic encephalomyelitis.

1984 • 38 citations

An analysis of the role of tumor necrosis factor in the phenotypic expression of actively induced experimental allergic orchitis and experimental allergic encephalomyelitis

1990 • 34 citations

Lyt-1 cells mediate acute murine experimental allergic encephalomyelitis.

1984 • 22 citations