Diversity of T cell receptor α and β chain genes expressed by human T cells specific for similar myelin basic protein peptide/major histocompatibility complexes

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

PROBLEMS OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS: REPORT BY THE PANEL ON THE EVALUATION OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS

1965 • 1,402 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis

1989 • 588 citations

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

1988 • 555 citations

Acquisition of immunologic self-tolerance

1989 • 484 citations

Structure, Organization and Polymorphism of Murine and Human T‐Cell Receptor a and β Chain Gene Families

1988 • 448 citations

Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain.

1985 • 416 citations

Vaccination Against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides

1989 • 416 citations

Limited heterogeneity of rearranged T-cell receptor Vα transcripts in brains of multiple sclerosis patients

1990 • 395 citations

Shared Human T Cell Receptor V _β Usage to Immunodominant Regions of Myelin Basic Protein

1990 • 386 citations

Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals.

1990 • 342 citations

Myelin basic protein‐specific T lymphocyte lines from MS patients and healthy individuals

1990 • 332 citations

Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different.

1989 • 321 citations

Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors.

1990 • 307 citations

A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis.

1991 • 286 citations

Diversity and structure of human T-cell receptor alpha-chain variable region genes.

1987 • 274 citations

Preferential T-cell receptor beta-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis.

1991 • 237 citations

Sequences and repertoire of the human T cell receptor α and β chain variable region genes in thymocytes

1987 • 226 citations

Restricted T-cell receptor V beta gene usage by myelin basic protein-specific T-cell clones in multiple sclerosis: predominant genes vary in individuals.

1991 • 193 citations

The V-region disease hypothesis: evidence from autoimmune encephalomyelitis

1989 • 190 citations

Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis.

1988 • 179 citations

Involvement of distinct murine T-cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein.

1988 • 172 citations

Prevention and treatment of murine experimental allergic encephalomyelitis with T cell receptor V beta-specific antibodies.

1990 • 164 citations

T cell receptor β chain usage in myelin basic protein‐specific rat T lymphocytes

1989 • 162 citations

Studies on the human T cell receptor α/β variable region genes. II. Identification of four additional V_β subfamilies

1991 • 148 citations

T-cell recognition of myelin basic protein

1991 • 134 citations

Studies on the human T cell receptor α/β variable region genes. I. Identification of 7 additional V_α subfamilies and 14 J_α gene segments

1991 • 121 citations

Diversity and structure of human T-cell receptor beta-chain variable region genes.

1986 • 112 citations

Complex rearrangements within the human J delta-C delta/J alpha-C alpha locus and aberrant recombination between J alpha segments.

1988 • 105 citations

Generation of diversity in T cell receptor repertoire specific for pigeon cytochrome c.

1987 • 104 citations

Response of human T lymphocyte lines to myelin basic protein: Association of dominant epitopes with HLA class II restriction molecules

1989 • 88 citations

Correlation of T cell receptor V beta gene family with MHC restriction.

1987 • 87 citations

Engineered secreted T-cell receptor alpha beta heterodimers.

1991 • 78 citations

T cell response to myelin basic protein epitopes in multiple sclerosis patients and healthy subjects

1991 • 70 citations

Evidence for multiple human T cell recognition sites on myelin basic protein

1989 • 65 citations

Chronic experimental autoimmune encephalomyelitis induced by the 89‐101 myelin basic protein peptide in B10RIII (H2^r) mice

1991 • 63 citations

Hypervariability of intronic simple (gt)n(ga)m repeats in HLA-DRB genes

1990 • 60 citations

HLA-DR2a is the dominant restriction molecule for the cytotoxic T cell response to myelin basic protein in DR2Dw2 individuals.

1990 • 60 citations

T cell receptor gene usage in the response to lambda repressor cI protein. An apparent bias in the usage of a V alpha gene element.

1988 • 54 citations

New perspectives on immunointervention in autoimmune diseases

1990 • 49 citations

Specificity of human T cell clones reactive to immunodominant epitopes of myelin basic protein

1991 • 43 citations

Heterogeneity of the T‐cell receptor β gene rearrangements generated in myelin basic protein‐specific T‐cell clones isolated from a patient with multiple sclerosis

1991 • 42 citations

Neurology

1985 • 34 citations

Preferential peptide specificity and HLA restriction of myelin basic protein-specific T cell clones derived from MS patients

1990 • 34 citations

Genetic differences in the T cell receptor alleles of LEW rats and their encephalomyelitis‐resistant derivative, LER, and their impact on the inheritance of EAE resistance

1991 • 30 citations

Detection of novel sequence heterogeneity and haplotypic diversity of HLA class II genes

1991 • 28 citations

The antigen receptor of an autoreactive T-cell clone from human rheumatic synovia

1989 • 20 citations