Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain.

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

T‐lymphocyte entry into the central nervous system

1991 • 1,168 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

1981 • 917 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

Determination of the length of the histological stages of apoptosis in normal liver and in altered hepatic foci of rats

1990 • 457 citations

Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin.

1991 • 455 citations

Apoptosis: molecular mechanisms in programmed cell death.

1991 • 425 citations

Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals.

1990 • 342 citations

Myelin basic protein‐specific T lymphocyte lines from MS patients and healthy individuals

1990 • 332 citations

The biochemistry of cell death by apoptosis

1990 • 326 citations

Suppression of experimentally induced autoimmune encephalomyelitis by cytolytic T–T cell interactions

1988 • 324 citations

Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.

1987 • 310 citations

Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone.

1987 • 294 citations

Cellular signalling in programmed cell death (apoptosis)

1990 • 255 citations

Genetic variation in the stress response: susceptibility to experimental allergic encephalomyelitis and implications for human inflammatory disease

1991 • 254 citations

Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis.

1990 • 234 citations

Apoptosis in the nervous system in experimental allergic encephalomyelitis

1991 • 229 citations

Programmed death of autoreactive thymocytes

1990 • 224 citations

The distribution of Ia antigen in the lesions of rat acute experimental allergic encephalomyelitis

1986 • 214 citations

Lymphocyte migration into brain modelled in vitro: Control by lymphocyte activation, cytokines, and antigen

1990 • 126 citations

In situ demonstration of proliferating cells in the rat central nervous system during experimental autoimmune encephalomyelitis. Evidence suggesting that most infiltrating T cells do not proliferate in the target organ.

1992 • 112 citations

Apoptosis of αβ T lymphocytes in the nervous system in experimental autoimmune encephalomyelitis: Its possible implications for recovery and acquired tolerance

1992 • 111 citations

Thymic cortical epithelial cells lack full capacity for antigen presentation

1989 • 85 citations

THE NATURE AND THE SPECIFICITY OF MONONUCLEAR CELLS IN EXPERIMENTAL AUTOIMMUNE INFLAMMATIONS AND THE MECHANISMS LEADING TO THEIR ACCUMULATION

1971 • 82 citations

Expression of Adhesion Molecules and Histocompatibility Antigens at the Blood‐Brain Barrier

1991 • 80 citations

Limiting dilution analysis of the frequency of antigen-reactive lymphocytes isolated from the central nervous system of Lewis rats with experimental allergic encephalomyelitis

1987 • 64 citations

Myelin basic protein specific T cell lines and clones derived from the CNS of rats with EAE only recognize encephalitogenic epitopes

1991 • 31 citations

Experimental autoimmune encephalomyelitis: isolation and characterization of inflammatory cells from the central nervous system

1989 • 15 citations

Central nervous system and blood lymphocytes in experimental allergic encephalomyelitis.

1983 • 5 citations