γδ T cell receptor repertoire in brain lesions of patients with multiple sclerosis

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Handbook of clinical neurology

1986 • 1,951 citations

Heat shock proteins and the immune response

1990 • 944 citations

Lymphocytes bearing antigen-specific γδ T-cell receptors accumulate in human infectious disease lesions

1989 • 592 citations

Specificity and function of T cells bearing γδ receptors

1988 • 570 citations

Evidence for extrathymic changes in the T cell receptor gamma/delta repertoire.

1990 • 510 citations

Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen.

1989 • 492 citations

Activation of γδ T Cells in the Primary Immune Response to Mycobacterium tuberculosis

1989 • 463 citations

Macrophages, lymphocytes, and plasma cells in the perivascular compartment in chronic multiple sclerosis.

1978 • 419 citations

Human γδ+ T cells respond to mycobacterial heat-shock protein

1989 • 417 citations

Multiple Sclerosis

1982 • 415 citations

Selection for T-cell receptor Vβ–Dβ–Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis

1993 • 400 citations

Limited heterogeneity of rearranged T-cell receptor Vα transcripts in brains of multiple sclerosis patients

1990 • 395 citations

Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.

1991 • 384 citations

Intraepithelial T Cells of the TcRγ/δ⁺CD8⁻ and Vδ1/Jδ1⁺ Phenotypes are Increased in Coeliac Disease

1989 • 311 citations

Multiple sclerosis☆Distribution of T cells, T cell subsets and Ia-positive macrophages in lesions of different ages

1983 • 309 citations

Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis.

1991 • 285 citations

Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions.

1992 • 280 citations

Recognition of heat shock proteins and γΔ cell function

1990 • 247 citations

Diversity of γδ T-cell receptors on murine intestinal intraepithelial lymphocytes

1989 • 217 citations

Distinct antigen receptor repertoires of two classes of murine epithelium-associated T cells

1989 • 215 citations

Distribution of T cells bearing different forms of the T cell receptor gamma/delta in normal and pathological human tissues.

1989 • 215 citations

Biology of the Human γ T‐Cell Receptor

1991 • 185 citations

In vitro responses to a 65-kilodalton mycobacterial protein by synovial T cells from inflammatory arthritis patients.

1989 • 175 citations

Rearrangement of two distinct T-cell γ-chain variable-region genes in human DNA

1986 • 174 citations

New subgroups in the human T cell rearranging V gamma gene locus.

1987 • 170 citations

T cell-specific gamma genes in C57BL/10 mice. Sequence and expression of new constant and variable region genes.

1986 • 154 citations

Sequence and organization of the diversity, joining, and constant region genes of the human T-cell delta-chain locus.

1988 • 153 citations

Clonal expansions of activated gamma/delta T cells in recent-onset multiple sclerosis.

1993 • 141 citations

Diversity and structure of human T cell receptor delta chain genes in peripheral blood gamma/delta-bearing T lymphocytes.

1989 • 137 citations

Genetic polymorphism and exon changes of the constant regions of the human T-cell rearranging gene gamma.

1986 • 136 citations

Multiple sclerosis: a pivotal role for the T cell in lesion development

1991 • 118 citations

Variable region genes in the human T-cell rearranging gamma (TRG) locus: V-J junction and homology with the mouse genes.

1988 • 117 citations

A predominance of the T cell receptor V gamma 2/V delta 2 subset in human mycobacteria-responsive T cells suggests germline gene encoded recognition.

1991 • 113 citations

Diversity and organization of human T cell receptor delta variable gene segments.

1989 • 107 citations

Repertoire of the human T cell gamma genes: high frequency of nonfunctional transcripts in thymus and mature T cells

1987 • 92 citations

Diversity in junctional sequences associated with the common human V gamma 9 and V delta 2 gene segments in normal blood and lung compared with the limited diversity in a granulomatous disease.

1990 • 90 citations

Non‐random expression of T cell receptor γ and δ variable gene segments in functional T lymphocyte clones from human peripheral blood

1989 • 86 citations

Expression of the hepatitis B virus surface, core and E antigen genes by stable rat and mouse cell lines

1982 • 78 citations

Analysis of the T cell repertoire using the PCR and specific oligonucleotide primers.

1992 • 76 citations

A functional γ gene formed from known γ-gene segments is not necessary for antigen-specific responses of murine cytotoxic T lymphocytes

1986 • 70 citations

Tγδ Cells in Juvenile Rheumatoid Arthritis and Rheumatoid Arthritis

1990 • 68 citations

The T cell receptors of human gamma delta T cells reactive to Mycobacterium tuberculosis are encoded by specific V genes but diverse V-J junctions.

1991 • 65 citations

Cytolytic T Lymphocytes with Natural Killer Activity in Thyroid Infiltrate of Patients with Hashimoto's Thyroiditis: Analysis at Clonal Level*

1986 • 63 citations

Development and selection of γδ T cells

1992 • 60 citations

Autoaggressive myocytotoxic T lymphocytes expressing an unusual gamma/delta T cell receptor.

1992 • 57 citations

Molecular Diversity of the Human T-Gamma Constant Region Genes

1987 • 57 citations

Microanatomic clonality of gamma delta T cells in human leishmaniasis lesions.

1992 • 57 citations

Variable gene usage of T cell receptor γ- and δ-chain transcripts expressed in synovia and peripheral blood of patients with rheumatoid arthritis

1992 • 54 citations

Measuring the Human T Cell Receptor γ-Chain Locus

1987 • 52 citations

T cell receptor diversity and activation markers in the V_δ1 subset of rheumatoid synovial fluid and peripheral blood T lymphocytes

1992 • 47 citations

Use of a variable alpha region to create a functional T-cell receptor delta chain.

1988 • 44 citations

T cell receptor heterogeneity in γδ T cell clones from intestinal biopsies of patients with celiac disease

1993 • 38 citations

T cells and their subpopulations in blood and synovial fluid from rheumatoid arthritis and spondyloarthritis

1991 • 38 citations

Rearrangement and junctional-site sequence analyses of T-cell receptor gamma genes in intestinal intraepithelial lymphocytes from murine athymic chimeras.

1991 • 34 citations

The human γ/δ+ and α/β+ T cells: A branched pathway of differentiation

1992 • 26 citations

Molecular genotypes of the human T cell receptor gamma-chain.

1988 • 26 citations

Detection and Measurement of Fat Cell-Binding Immunoglobulins: A New Method Applicable to the Diagnosis and Study of Graves' Disease*

1986 • 17 citations

Deleted Work

1955 • 0 citations