Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors.

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

PROBLEMS OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS: REPORT BY THE PANEL ON THE EVALUATION OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS

1965 • 1,402 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis

1989 • 588 citations

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

1988 • 555 citations

Vaccination Against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides

1989 • 416 citations

Measles Encephalomyelitis — Clinical and Immunologic Studies

1984 • 404 citations

Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy

1989 • 394 citations

Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals.

1990 • 342 citations

Experimental Allergic Encephalomyelitis. A Useful Model for Multiple Sclerosis

1984 • 340 citations

DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression.

1985 • 340 citations

Human major histocompatibility complex contains genes for the major heat shock protein HSP70.

1989 • 336 citations

Myelin basic protein‐specific T lymphocyte lines from MS patients and healthy individuals

1990 • 332 citations

Isolation of myelin basic protein-reactive T-cell lines from normal human blood

1983 • 270 citations

A New Cluster of Genes Within the Human Major Histocompatibility Complex

1989 • 247 citations

Adoptive transfer of EAE-like lesions from rats with coronavirus-induced demyelinating encephalomyelitis

1983 • 233 citations

Allelic variation in the DR subregion of the human major histocompatibility complex.

1987 • 220 citations

T cell recognition as the target for immune intervention in autoimmune disease

1989 • 218 citations

Ia-restricted encephalitogenic T lymphocytes mediating EAE lyse autoantigen-presenting astrocytes

1986 • 214 citations

Autoaggressive T lymphocyte lines recognizing the encephalitogenic region of myelin basic protein: in vitro selection from unprimed rat T lymphocyte populations.

1985 • 196 citations

Myelin Basic Protein as an Encephalitogen in Encephalomyelitis and Polyneuritis Following Rabies Vaccination

1987 • 175 citations

Nomenclature for factors of the HLA system, 1996

1997 • 171 citations

Nomenclature for factors of the HLA system, 1989

1990 • 141 citations

T Cell Receptors in Murine Autoimmune Diseases

1989 • 137 citations

The T-Cell Receptor Repertoire and Autoimmune Diseases

1989 • 124 citations

[31] Myelin basic proteins

1974 • 111 citations

Response of human T lymphocyte lines to myelin basic protein: Association of dominant epitopes with HLA class II restriction molecules

1989 • 88 citations

The sequential limited degradation of bovine myelin basic protein by bovine brain cathepsin D.

1979 • 82 citations

Autoimmune T cells: Immune recognition of normal and variant peptide epitopes and peptide-based therapy

1989 • 81 citations

Analysis of HLA-DR glycoproteins by DNA-mediated gene transfer. Definition of DR2 beta gene products and antigen presentation to T cell clones from leprosy patients.

1988 • 66 citations

Evidence for multiple human T cell recognition sites on myelin basic protein

1989 • 65 citations

Human T‐cell response to myelin basic protein in multiple sclerosis patients and healthy subjects

1988 • 54 citations

Rapid method based on reversed-phase high-performance liquid chromatography for purification of human myelin basic protein and its thrombic and endoproteinase Lys-C peptides

1990 • 9 citations

Human myelin basic protein-specific cytolytic T lymphocyte clones are functionally restricted by HLA class II gene products

1989 • 7 citations