The V-region disease hypothesis: evidence from autoimmune encephalomyelitis

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

Amino Acid Homology Between the Encephalitogenic Site of Myelin Basic Protein and Virus: Mechanism for Autoimmunity

1985 • 941 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

OBSERVATIONS ON ATTEMPTS TO PRODUCE ACUTE DISSEMINATED ENCEPHALOMYELITIS IN MONKEYS

1933 • 629 citations

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

1988 • 555 citations

Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein

1981 • 520 citations

The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens

1988 • 491 citations

T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis

1986 • 471 citations

Anti-Idiotypic Network Induced by T Cell Vaccination Against Experimental Autoimmune Encephalomyelitis

1988 • 409 citations

A novel population of T-cell receptor αβ-bearing thymocytes which predominantly expresses a single Vβ gene family

1987 • 397 citations

The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype.

1984 • 389 citations

Suppression of experimentally induced autoimmune encephalomyelitis by cytolytic T–T cell interactions

1988 • 324 citations

Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different.

1989 • 321 citations

Sequence Homology Between Certain Viral Proteins and Proteins Related to Encephalomyelitis and Neuritis

1985 • 243 citations

Developmentally regulated expression of T cell receptor beta chain variable domains in immature thymocytes.

1987 • 230 citations

Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis.

1988 • 179 citations

Involvement of distinct murine T-cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein.

1988 • 172 citations

CHEMICAL STUDIES ON AN ENCEPHALITOGENIC PROTEIN FROM GUINEA PIG BRAIN

1965 • 151 citations

Encephalitogenic T cell clones specific for myelin basic protein. An unusual bias in antigen recognition.

1985 • 147 citations

Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL/J mice.

1988 • 146 citations

A suppressor T-lymphocyte cell line for autoimmune encephalomyelitis

1988 • 138 citations

Induction of experimental allergic encephalomyelitis in PL/J and (SJL/J x PL/J)F1 mice by myelin basic protein and its peptides: localization of a second encephalitogenic determinant.

1983 • 137 citations

Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis.

1988 • 132 citations

The Structure of T-Cell Epitopes

1987 • 130 citations

Experimental Allergic Encephalomyelitis in the Rat: Response to Encephalitogenic Proteins and Peptides

1973 • 122 citations

Protection from experimental allergic encephalomyelitis conferred by a monoclonal antibody directed against a shared idiotype on rat T cell receptors specific for myelin basic protein.

1988 • 104 citations

Encephalitogenic activity of guinea pig myelin basic protein in the SJL mouse.

1982 • 95 citations

Multiple discrete encephalitogenic epitopes of the autoantigen myelin basic protein include a determinant for I-E class II-restricted T cells.

1988 • 92 citations

T-cell vaccination

1988 • 83 citations

Distinct recognition phenotypes exist for T cell clones specific for small peptide regions of proteins. Implications for the mechanisms underlying major histocompatibility complex-restricted antigen recognition and clonal deletion models of immune response gene defects.

1985 • 74 citations

Differences in the repertoire of the Lewis rat T cell response to self and non-self myelin basic proteins.

1988 • 58 citations

HUMAN RABIES AND RABIES VACCINE ENCEPHALOMYELITIS

1930 • 45 citations

EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS: SEQUESTERED ENCEPHALITOGENIC DETERMINANT IN THE BOVINE MYELIN BASIC PROTEIN2

1979 • 35 citations

Antibodies against I-A and I-E determinants inhibit the activation and function of encephalitogenic T-lymphocyte lines

1986 • 34 citations

The autoreactive T cell population in experimental allergic encephalomyelitis: T cell receptor β-chain rearrangements

1988 • 25 citations

Encephalitogenic T cell clones with variant receptor specificity.

1988 • 22 citations