Anti-adhesion molecule therapy in experimental autoimmune encephalomyelitis

Adhesion receptors of the immune system

1990 • 6,585 citations

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

1992 • 1,711 citations

Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells.

1988 • 988 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.

1993 • 837 citations

Specific Acceptance of Cardiac Allograft After Treatment with Antibodies to ICAM-1 and LFA-1

1992 • 737 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1+ 2- T lymphocytes.

1981 • 592 citations

Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis

1989 • 588 citations

Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein

1981 • 520 citations

Anti—tumor necrosis factor therapy abrogates autoimmune demyelination

1991 • 434 citations

Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system.

1990 • 388 citations

Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-beta 1.

1991 • 385 citations

Migration of Hematogenous Cells Through the Blood‐Brain Barrier and the Initiation of CNS Inflammation

1991 • 362 citations

The function of human intercellular adhesion molecule‐1 (ICAM‐1) in the generation of an immune response

1988 • 351 citations

Four molecular pathways of T cell adhesion to endothelial cells: roles of LFA-1, VCAM-1, and ELAM-1 and changes in pathway hierarchy under different activation conditions.

1991 • 343 citations

Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes.

1989 • 339 citations

Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice

1984 • 311 citations

Successful treatment of experimental allergic encephalomyelitis with transforming growth factor-beta 1.

1991 • 243 citations

Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis.

1990 • 234 citations

Homing to central nervous system vasculature by antigen-specific lymphocytes. II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination.

1990 • 229 citations

In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis.

1981 • 228 citations

Human T lymphocyte adhesion to endothelial cells and transendothelial migration. Alteration of receptor use relates to the activation status of both the T cell and the endothelial cell.

1990 • 199 citations

Upregulation and coexpression of adhesion molecules correlate with relapsing autoimmune demyelination in the central nervous system.

1990 • 173 citations

Chronologic neuropathology of relapsing experimental allergic encephalomyelitis in the mouse.

1982 • 164 citations

Anti I-A antibody suppresses active encephalomyelitis: treatment model for diseases linked to IR genes.

1983 • 160 citations

Reduction of graft failure by a monoclonal antibody (anti-LFA-1 CD11a) after HLA nonidentical bone marrow transplantation in children with immunodeficiencies, osteopetrosis, and Fanconi's anemia: a European Group for Immunodeficiency/European Group for Bone Marrow Transplantation report

1991 • 142 citations

Late administration of monoclonal antibody to leukocyte function‐antigen 1 abrogates incipient murine cerebral malaria

1991 • 128 citations

Adhesion-related molecules in the central nervous system. Upregulation correlates with inflammatory cell influx during relapsing experimental autoimmune encephalomyelitis.

1991 • 128 citations

Expression of vascular addressins and ICAM-1 by endothelial cells in the spinal cord during chronic relapsing experimental allergic encephalomyelitis in the Biozzi AB/H mouse.

1991 • 112 citations

Endothelial cell expression of the intercellular adhesion molecule-1 (ICAM-1) in the central nervous system of guinea pigs during acute and chronic relapsing experimental allergic encephalomyelitis

1990 • 110 citations

Sites of egress of inflammatory cells and horseradish peroxidase transport across the blood-brain barrier in a murine model of chronic relapsing experimental allergic encephalomyelitis

1989 • 84 citations

Chronologic localization of myelin‐reactive cells in the lesions of relapsing EAE

1993 • 78 citations

The effect of anti-adhesion molecule antibody on the development of collagen-induced arthritis

1992 • 74 citations

Role of ICAM-1 in antigen presentation demonstrated by ICAM-1 defective mutants.

1990 • 73 citations

Late treatment with anti‐LFA‐1 (CD11a) antibody prevents cerebral malaria in a mouse model

1991 • 71 citations

Treatment of established chronic relapsing experimental allergic encephalomyelitis with anti-L3T4 antibodies.

1986 • 67 citations

REDUCTION IN THE SEVERITY OF GRAFT-VERSUS-HOST DISEASE AND INCREASED SURVIVAL IN ALLOGENEIC MICE BY TREATMENT WITH MONOCLONAL ANTIBODIES TO CELL ADHESION ANTIGENS LFA-lα AND MALA-2

1991 • 64 citations

Adhesion molecules and central nervous system inflammation

1992 • 36 citations

Immune cell traffic control and the central nervous system

1992 • 24 citations

Suppressive activity of long-term myelin basic protein-specific SJL T cell lines

1989 • 8 citations