Identification of a novel T cell epitope of human proteolipid protein (residues 40–60) recognized by proliferative and cytolytic CD4+ T cells from multiple sclerosis patients

Large Scale Preparation of Myelin Basic Protein from Central Nervous Tissue of Several Mammalian Species

1972 • 949 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

Prediction of immunodominant helper T cell antigenic sites from the primary sequence.

1987 • 483 citations

Multiple Sclerosis

1982 • 415 citations

Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.

1989 • 372 citations

Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals.

1990 • 342 citations

A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis.

1991 • 286 citations

Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls

1991 • 258 citations

Individual exons encode the integral membrane domains of human myelin proteolipid protein.

1986 • 177 citations

Multiple Sclerosis as a Disease of Immune Regulation

1984 • 169 citations

Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis

1992 • 163 citations

Myelin‐specific proteolipid protein is expressed in myelinating schwann cells but is not incorporated into myelin sheaths

1987 • 154 citations

Diversity in fine specificity and T cell receptor usage of the human CD4+ cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106.

1992 • 148 citations

Chronic Relapsing Experimental Allergic Encephalomyelitis

1979 • 147 citations

Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides.

1990 • 140 citations

Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating experimental autoimmune encephalomyelitis.

1991 • 130 citations

Myelin basic protein and proteolipid protein reactivity of brain- and cerebrospinal fluid-derived T cell clones in multiple sclerosis and postinfectious encephalomyelitis.

1987 • 127 citations

A synthetic peptide from myelin proteolipid protein induces experimental allergic encephalomyelitis.

1988 • 126 citations

Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis

1986 • 124 citations

A STUDY OF THE CHEMICAL NATURE OF COMPONENTS OF BOVINE WHITE MATTER EFFECTIVE IN PRODUCING ALLERGIC ENCEPHALOMYELITIS IN THE RABBIT

1954 • 122 citations

Immunotherapy of multiple sclerosis

1988 • 113 citations

PURIFICATION AND IMMUNOHISTOCHEMICAL LOCALIZATION OF RAT BRAIN MYELIN PROTEOLIPID PROTEIN¹

1977 • 102 citations

Selective inhibition of antigen presentation to cloned T cells by protease inhibitors

1989 • 84 citations

Myelin proteolipid protein induces demyelinating disease in mice

1987 • 83 citations

Experimental allergic encephalomyelitis induced by proteolipid apoprotein in Lewis rats

1986 • 78 citations

Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction.

1990 • 77 citations

Chronic experimental allergic encephalomyelitis in guinea pigs induced by proteolipid protein

1985 • 75 citations

Location of a new encephalitogenic epitope (residues 43 to 64) in proteolipid protein that induces relapsing experimental autoimmune encephalomyelitis in PL/J and (SJL x PL)F1 mice.

1991 • 72 citations

DM-20, a proteolipid apoprotein, is an encephalitogen of acute and relapsing autoimmune encephalomyelitis in mice.

1986 • 67 citations

Evidence for multiple human T cell recognition sites on myelin basic protein

1989 • 65 citations

Peripheral blood mononuclear cells from multiple sclerosis patients recognize myelin proteolipid protein and selected peptides

1991 • 63 citations

Processing of tetanus toxin by human antigen-presenting cells. Evidence for donor and epitope-specific processing pathways.

1989 • 62 citations

HLA-DR2a is the dominant restriction molecule for the cytotoxic T cell response to myelin basic protein in DR2Dw2 individuals.

1990 • 60 citations

The adoptive transfer of chronic relapsing experimental allergic encephalomyelitis with lymph node cells sensitized to myelin proteolipid protein

1989 • 55 citations

Neuronal and Glial Proteins: Structure, Function, and Clinical Application

1988 • 46 citations

The immunopathology of chronic experimental allergic encephalomyelitis induced in rabbits with bovine proteolipid protein.

1986 • 40 citations

Cellular hypersensitivity in attacks of multiple sclerosis

1977 • 38 citations

The development and characterization of encephalitogenic cloned T cells specific for myelin proteolipid protein

1990 • 35 citations

Human T lymphocyte response to myelin basic protein: Selection of T lymphocyte lines from mbp‐responsive donors

1989 • 30 citations

Autoimmune Demyelination in the Central Nervous Systema

1988 • 27 citations

MYELIN PROTEOLIPID PROTEIN

1988 • 24 citations

Radioimmunoassay for Central Nervous System Myelin‐Specific Proteolipid Protein

1981 • 23 citations

Immune processing of proteolipid protein by subsets of antigen-presenting spleen cells

1992 • 16 citations

Autoantigen-induced self lysis of human myelin basic protein-specific T lymphocytes

1991 • 8 citations