Virus-reactive and autoreactive T cells are accumulated in cerebrospinal fluid in multiple sclerosis

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

MYELINATION IN RAT BRAIN: METHOD OF MYELIN ISOLATION¹

1973 • 1,412 citations

PROBLEMS OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS: REPORT BY THE PANEL ON THE EVALUATION OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS

1965 • 1,402 citations

Human TH1 and TH2 subsets: doubt no more

1991 • 1,103 citations

Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values

1977 • 867 citations

Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values

1977 • 779 citations

Natural autoantibodies: from ‘horror autotoxicus’ to ‘gnothi seauton’

1991 • 723 citations

Reverse ELISPOT assay for clonal analysis of cytokine production I. Enumeration of gamma-interferon-secreting cells

1988 • 496 citations

Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma.

1990 • 363 citations

Measles Antibodies in Multiple Sclerosis.

1962 • 320 citations

T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis.

1991 • 314 citations

IL-4 inhibits the synthesis of IFN-gamma and induces the synthesis of IgE in human mixed lymphocyte cultures.

1990 • 262 citations

Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls

1991 • 258 citations

On the presence of Ia-positive endothelial cells and astrocytes in multiple sclerosis lesions and its relevance to antigen presentation

1985 • 241 citations

Immunocytochemical observations on the distribution of myelin‐associated glycoprotein and myelin basic protein in multiple sclerosis lesions

1980 • 240 citations

Substitute for Benzidine in Myeloperoxidase Stains

1975 • 219 citations

Principles of albumin and IgG analyses in neurological disorders. II. Relation of the concentration of the proteins in serum and cerebrospinal fluid

1977 • 181 citations

Comparison of Antibodies Against Different Viruses in Cerebrospinal Fluid and Serum Samples from Patients with Multiple Sclerosis

1974 • 173 citations

Principles of albumin and IgG analyses in neurological disorders. II. Relation of the concentration of the proteins in serum and cerebrospinal fluid

1977 • 169 citations

Multiple sclerosis: relevance of Class I and Class II MHC-expressing cells to lesion development

1987 • 169 citations

CSF Antibody to Myelin Basic Protein

1980 • 144 citations

Regulation of human IgE synthesis. I. Human IgE synthesis in vitro is determined by the reciprocal antagonistic effects of interleukin 4 and interferon‐γ

1990 • 139 citations

Antimyelin basic protein and antimyelin antibody‐producing cells in multiple sclerosis

1990 • 133 citations

Detection of intracellular expression and secretion of interferon‐γ at the single‐cell level after activation of human T cells with tetanus toxoid in vitro

1990 • 130 citations

Oligoclonal IgG Bands in Cerebrospinal Fluid

1987 • 121 citations

Acetylcholine receptor-reactive T and B cells in myasthenia gravis and controls.

1991 • 108 citations

T cell immunity and interferon-γ secretion during experimental allergic encephalomyelitis in Lewis rats

1991 • 107 citations

Immunoblot detection of oligoclonal anti‐myelin basic protein IgG antibodies in cerebrospinal fluid in multiple sclerosis

1987 • 106 citations

CSF antibodies to myelin basic protein and to myelin-associated glycoprotein in multiple sclerosis. Evidence of the intrathecal production of antibodies

1983 • 96 citations

Intrathecal antibody synthesis to virus antigens in multiple sclerosis.

1983 • 83 citations

Purification and partial characterization of the myelin-associated glycoprotein from adult rat brain

1983 • 79 citations

Monoclonal antibody two-site ELISA for human IFN-γ

1989 • 79 citations

“Allergic” encephalomyelitis

1960 • 78 citations

Antibodies to Myelin-Associated Glycoprotein (MAG) in the cerebrospinal fluid of multiple sclerosis patients

1989 • 77 citations

Structural components of measles virus.

1972 • 75 citations

Multiple Sclerosis: Cells Secreting Antibodies Against Myelin‐Associated Glycoprotein are Present in Cerebrospinal Fluid

1991 • 68 citations

Quantitation of the Myelin‐Associated Glycoprotein in Human Nervous Tissue from Controls and Multiple Sclerosis Patients

1986 • 67 citations

Humoral Immunity in Neurological Diseases

1979 • 60 citations

Persistent anti-myelin basic protein IgG antibody response in multiple sclerosis cerebrospinal fluid

1990 • 56 citations

A quantitation of myelin‐associated glycoprotein and myelin basic protein loss in different demyelinating disease

1985 • 55 citations

The distribution of myelin-associated glycoprotein and myelin basic protein in actively demyelinating multiple sclerosis lesions

1984 • 51 citations

Measles Antibodies in Multiple Sclerosis

1963 • 49 citations

CSF antibodies to myelin basic protein and oligodendrocytes in multiple sclerosis and other neurological diseases

2009 • 47 citations

Myelin basic protein antibodies in the serum and CSF of multiple sclerosis and subacute sclerosing panencephalitis patients

2009 • 46 citations

Myelin‐associated glycoprotein in multiple sclerosis lesions: A quantitative and qualitative analysis

1987 • 41 citations

Binding of 125 I myelin basic protein by serum and cerebrospinal fluid.

1972 • 41 citations

Cerebrospinal fluid autoantibodies to myelin basic protein in multiple sclerosis patients

1989 • 38 citations

Failure to detect antibodies to myelin basic protein or peptic fragments of myelin basic protein in CSF of patients with MS

1983 • 38 citations

B cells and antibodies in MS

1989 • 36 citations

THE CEREBRO-SPINAL FLUID IN MULTIPLE SCLEROSIS.

1920 • 35 citations

Demonstration of cerebrospinal fluid lymphocytes sensitized against virus antigens in mumps meningitis

2009 • 33 citations

Further Lymphocyte Characterization in the Central Nervous System in Multiple Sclerosis^a

1984 • 33 citations

Advances in CSF protein research and diagnosis

1987 • 31 citations

Demyelinating diseases

1997 • 29 citations

Lymphocyte stimulation with measles antigen in multiple sclerosis

1970 • 28 citations

T cell responses to human recombinant acetylcholine receptor‐α subunitin myasthenia gravis and controls

1992 • 25 citations

Multiple sclerosis

1978 • 22 citations

Cells producing antibody to measles and herpes simplex virus in cerebrospinal fluid and blood of patients with multiple sclerosis and controls.

1989 • 20 citations

CELLS SECRETING ANTI-MAG ANTIBODY OCCUR IN CEREBROSPINAL FLUID AND BONE MARROW IN PATIENTS WITH POLYNEUROPATHY ASSOCIATED WITH M COMPONENT

1991 • 16 citations

Advances in neuroimmunology

1988 • 8 citations

Antibody‐Producing Cells in CSF and Peripheral Blood A New Principle for Evaluation of B‐Cell Response in Inflammatory Nervous System Diseases

1988 • 6 citations