Neurological autoimmune disease and the trimolecular complex of T‐lymphocytes

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

The clonal selection theory of acquired immunity

1959 • 2,008 citations

Handbook of clinical neurology

1986 • 1,951 citations

The clonal selection theory of acquired immunity

1959 • 1,576 citations

Binding of immunogenic peptides to Ia histocompatibility molecules

1985 • 1,209 citations

A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

1988 • 1,161 citations

The Lymphocyte Function Associated LFA-1, CD2, and LFA-3 Molecules: Cell Adhesion Receptors of the Immune System

1987 • 1,104 citations

The Basis for the Immunoregulatory Role of Macrophages and Other Accessory Cells

1987 • 1,040 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

1981 • 917 citations

The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble

1988 • 786 citations

Cellular immune reactivity within the CNS

1986 • 771 citations

A Molecular Basis for MHC Class II—Associated Autoimmunity

1988 • 707 citations

The Relation Between Major Histocompatibility Complex (MHC) Restriction and the Capacity of Ia to Bind Immunogenic Peptides

1987 • 696 citations

A sequence pattern common to T cell epitopes.

1988 • 623 citations

Dendritic Cells: Features and Functions

1980 • 585 citations

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

1988 • 555 citations

The T Cell Receptor

1987 • 554 citations

T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination

1985 • 522 citations

Prediction of immunodominant helper T cell antigenic sites from the primary sequence.

1987 • 483 citations

T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis

1986 • 471 citations

Isolation and characterization of antigen-la complexes involved in T cell recognition

1986 • 470 citations

Structure, Organization and Polymorphism of Murine and Human T‐Cell Receptor a and β Chain Gene Families

1988 • 448 citations

Anti-Idiotypic Network Induced by T Cell Vaccination Against Experimental Autoimmune Encephalomyelitis

1988 • 409 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments.

1988 • 404 citations

Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

1987 • 367 citations

Myasthenia Gravis

1988 • 341 citations

Experimental Allergic Encephalomyelitis. A Useful Model for Multiple Sclerosis

1984 • 340 citations

Suppression of experimentally induced autoimmune encephalomyelitis by cytolytic T–T cell interactions

1988 • 324 citations

Antigen Presentation Pathways to Class I and Class II MHC‐Restricted T Lymphocytes

1987 • 322 citations

Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice

1984 • 311 citations

Cell Surface Molecules and Early Events Involved in Human T Lymphocyte Activation

1987 • 297 citations

Identification of the T-cell and Ia contact residues of a T-cell antigenic epitope

1987 • 297 citations

Isolation of myelin basic protein-reactive T-cell lines from normal human blood

1983 • 270 citations

Immunological self/nonself discrimination

1999 • 265 citations

Myasthenia gravis and myasthenic syndromes.

1992 • 248 citations

In vivo competition between self peptides and foreign antigens in T-cell activation

1988 • 216 citations

Antigenic competition at the level of peptide-Ia binding.

1986 • 216 citations

Autoaggressive T lymphocyte lines recognizing the encephalitogenic region of myelin basic protein: in vitro selection from unprimed rat T lymphocyte populations.

1985 • 196 citations

Antigen presentation in the peripheral nervous system: Schwann cells present endogenous myelin autoantigens to lymphocytes

1986 • 184 citations

Frontiers of the immune system

1988 • 174 citations

Involvement of distinct murine T-cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein.

1988 • 172 citations

Autologous Peptides Constitutively Occupy the Antigen Binding Site on Ia

1988 • 157 citations

Immune‐Mediated Encephalitis: On the Role of Antigen‐Presenting Cells in Brain Tissue

1987 • 155 citations

Functional and Molecular Aspects of Human T Lymphocyte Activation via T3‐Ti and Tl1 Pathways

1987 • 152 citations

Direct binding of influenza peptides to class I HLA molecules

1989 • 149 citations

Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL/J mice.

1988 • 146 citations

Induction of experimental allergic encephalomyelitis in PL/J and (SJL/J x PL/J)F1 mice by myelin basic protein and its peptides: localization of a second encephalitogenic determinant.

1983 • 137 citations

HLA-DQ BETA-CHAIN POLYMORPHISM LINKED TO MYASTHENIA GRAVIS

1986 • 135 citations

Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis.

1988 • 132 citations

In vitro proliferative responses and antibody titers specific to human acetylcholine receptor synthetic peptides in patients with myasthenia gravis and relation to HLA class II genes.

1988 • 127 citations

Specificity of T lymphocyte lines for peptides of myelin basic protein.

1985 • 125 citations

A speculative view of the multicomponent nature of T cell antigen recognition

1986 • 117 citations

T Cell CD3-ζη Heterodimer Expression and Coupling to Phosphoinositide Hydrolysis

1988 • 113 citations

The Self, the World and Autoimmunity

1988 • 112 citations

Direct evidence for functional self-protein/Ia-molecule complexes in vivo.

1988 • 111 citations

The Ia molecule of the antigen-presenting cell plays a critical role in immune response gene regulation of T cell activation.

1983 • 105 citations

Human T-helper lymphocytes in myasthenia gravis recognize the nicotinic receptor alpha subunit.

1987 • 100 citations

Region of peptide 125-147 of acetylcholine receptor alpha subunit is exposed at neuromuscular junction and induces experimental autoimmune myasthenia gravis, T-cell immunity, and modulating autoantibodies.

1985 • 98 citations

Encephalitogenic activity of guinea pig myelin basic protein in the SJL mouse.

1982 • 95 citations

Specificity of the T cell immune response to acetylcholine receptor in experimental autoimmune myasthenia gravis. Response to subunits and synthetic peptides.

1988 • 92 citations

T Lymphocytes: Ontogeny, Function, and Relevance to Clinical Disorders

1987 • 89 citations

Induction of experimental allergic encephalomyelitis in Lewis rats with purified synthetic peptides: delineation of antigenic determinants for encephalitogenicity, in vitro activation of cellular transfer, and proliferation of lymphocytes.

1985 • 88 citations

THYMIC MYOGENESIS, T‐LYMPHOCYTES AND THE PATHOGENESIS OF MYASTHENIA GRAVIS*

1981 • 88 citations

Immune response of Lewis rats to peptide C1 (residues 68-88) of guinea pig and rat myelin basic proteins.

1977 • 87 citations

Experimental autoimmune encephalomyelitis mediated by T lymphocyte lines: genotype of antigen-presenting cells influences immunodominant epitope of basic protein.

1986 • 79 citations

A juxta-membrane epitope on the human acetylcholine receptor recognized by T cells in myasthenia gravis.

1988 • 78 citations

Immunodominance in T lymphocyte recognition

1988 • 70 citations

Antigen processing and CD4+ T cell depletion in AIDS

1988 • 65 citations

Autoimmune T lymphocytes in myasthenia gravis. Determination of target epitopes using T lines and recombinant products of the mouse nicotinic acetylcholine receptor gene.

1989 • 65 citations

Diseases of the Nervous System

1956 • 64 citations

Amphipathic segment of the nicotinic receptor alpha subunit contains epitopes recognized by T lymphocytes in myasthenia gravis.

1988 • 62 citations

T lymphocyte recognition of acetylcholine receptor: Localization of the full T cell recognition profile on the extracellular part of the α chain of Torpedo californica acetylcholine receptor

1987 • 60 citations

Genetic restriction of autoreactive acetylcholine receptor-specific T lymphocytes in myasthenia gravis.

1985 • 54 citations

T cell specificity for class II (I-A) and the encephalitogenic N-terminal epitope of the autoantigen myelin basic protein.

1987 • 52 citations

Peptide specificities of myelin basic protein‐reactive human T‐cell clones

1988 • 40 citations

T cell epitopes in experimental autoimmune myasthenia gravis of the rat: strain‐specific epitopes and cross‐reaction between two distinct segments of the α chain of the nicotinic acetylcholine receptor (torpedo californica)

1988 • 40 citations

Immunological Diseases.

1988 • 30 citations

Analysis of helper-T-cell function by acetylcholine receptor-reactive cell lines of defined AChR-subunit specificity

1987 • 29 citations

Myelin basic protein-specific CD4+ cytolytic T-lymphocyte clones isolated from multiple sclerosis patients

1988 • 27 citations

Adoptively transferred experimental autoimmune encephalomyelitis in SJL/J, PL/J, and (SJL/J x PL/J)F1 mice. Influence of I-A haplotype on encephalitogenic epitope of myelin basic protein.

1988 • 26 citations

The autoreactive T cell population in experimental allergic encephalomyelitis: T cell receptor β-chain rearrangements

1988 • 25 citations

Analysis of T cell receptor-gene rearrangement in T cells from the cerebrospinal fluid of patients with multiple sclerosis

1987 • 21 citations

T cell hybridomas reactive with the acetylcholine receptor and its subunits.

1987 • 19 citations

Mammalian T-lymphocyte antigen receptor genes: genetic and nongenetic potential to generate variability

1987 • 17 citations

Mapping the autoimmunizing epitopes on acetylcholine receptors

1987 • 14 citations

Strategies for the modulation of neuroimmunological disease at the level of autoreactive T-lymphocytes

1985 • 13 citations

Proliferative responses to acetylcholine receptor peptides in myasthenia gravis

1987 • 5 citations